Learning objectives: * Understand the difference between cell growth and proliferation * Describe the major events of the cell cycle * Appreciate the roles of cyclins and cyclin-dependent kinases in regulating cell cycle progression * Provide examples of disordered signaling in cancer * Describe checkpoints and how they regulate the correct expression of the cell cycle * Understand the role of apoptosis in preventing inappropriate cell proliferation

PHSI3012 02-2 Limitless replicative potential of cancer cells Content: * Hallmarks of Cancer * Cellular proliferation * Mortality vs immortality * Telomeres * Telomerase * ALT

Overview: - Overview of metastasis - Define each of the general stages of metastasis - Provide some examples of genes involved in each stage - Different metastasis models - Examples of therapeutic options

Overview: - Analysis of cell phenotypes associated with cancer - Analysis of cancer cell phenotypes in vivo - Modelling metastasis - Mouse models of epithelial carcinogenesis - Survival and cross-sectional analysis - Modelling therapeutic treatment