Pharmacology IV

Description

Praxis Tests: Pharmacology Quiz on Pharmacology IV, created by ACAPUN INSTITUTE on 08/11/2021.
ACAPUN INSTITUTE
Quiz by ACAPUN INSTITUTE, updated more than 1 year ago
ACAPUN INSTITUTE
Created by ACAPUN INSTITUTE over 2 years ago
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Resource summary

Question 1

Question
A pharmacologic agonist is a chemical substance that
Answer
  • a. Binds to a specific receptor and produces a response
  • b. Elicits a pharmacologic response without binding to a receptor
  • c. Possesses the property of affinity but not of intrinsic activity
  • d. Exhibits no activity except to oppose the effect of an antagonist

Question 2

Question
When comparing drugs with respect to intensity of response, the drug that produces the greatest maximum effect is the one with the highest
Answer
  • a. Affinity
  • b. Potency
  • c. Efficacy
  • d. Therapeutic index

Question 3

Question
If drug has a greater efficacy than drug B, then drug A
Answer
  • a. Is more toxic than drug B
  • b. Has a greater affinity for the receptor than drug B
  • c. Has a greater margin of safety than drug B
  • d. Is capable of producing a greater maximum effect than drug B

Question 4

Question
A drug with a high LD50 and a low ED50 has a
Answer
  • a. High therapeutic index and is, therefore, very dangerous
  • b. High therapeutic index and is, therefore, relatively safe
  • c. Low therapeutic index and is, therefore, very dangerous
  • d. Low therapeutic index and is, therefore, relatively safe

Question 5

Question
The ratio of the median lethal dose (LD50) to the median effective dose (ED50) is the
Answer
  • a. Morbidity index
  • b. Mortality index
  • c. Anesthetic ratio
  • d. Therapeutic index

Question 6

Question
The therapeutic index of a drug is the ratio of
Answer
  • a. The effective dose to the toxic dose
  • b. Half the toxic dose to half the effective dose
  • c. The maximum tolerated dose to the minimum effective dose
  • d. The lethal dose for 50% of animals to the effective dose for 50% of animals

Question 7

Question
The phenomenon in which two drugs produce opposite effects on a physiologic system but do not act at the same receptor site is
Answer
  • a. Potentiation
  • b. Chemical Antagonism
  • c. Competitive antagonism
  • d. Physiologic antagonism

Question 8

Question
Epinephrine antagonizes the effects of histamine by
Answer
  • a. Preventing the release of histamine
  • b. Acting on the central nervous system
  • c. Producing physiologic actions opposite to that of histamine
  • d. Competitively blocking histamine at the cellular receptor site

Question 9

Question
Interaction between nitroglycerin and epinephrine is what type of antagonism?
Answer
  • a. Allosteric
  • b. Physiologic
  • c. Biochemical
  • d. Competitive
  • e. Pharmacologic

Question 10

Question
When the combined action of two drugs is greater than the sum of their individual actions, this is
Answer
  • a. Induction
  • b. Synergism
  • c. Idiosyncrasy
  • d. Hypersensitivity
  • e. Cumulative action

Question 11

Question
Which of the following responses is least predictable in occurrence?
Answer
  • a. Toxicity
  • b. Side-effects
  • c. Idiosyncrasy
  • d. Tachyphylaxis
  • e. Therapeutic effects

Question 12

Question
Idiosyncrasies to drugs are related to
Answer
  • a. Species
  • b. Genetic factors
  • c. Age of the patient
  • d. All of the above

Question 13

Question
Two drugs, A and B, have the same mechanism of action. Drug A in a dose of 5 mg. produces the same magnitude of response as drug B in a dose of 500 mg. Which of the following statements is correct?
Answer
  • a. Drug A is less toxic
  • b. Drug A is more efficacious
  • c. Drug A is 100 times as potent
  • d. Drug A has a shorter duration of action
  • e. Drug A is a better drug to use when a maximal response is desired

Question 14

Question
According to the theory that agonists and antagonists occupy the same receptor site, an effective antagonist should exhibit
Answer
  • a. High intrinsic activity and high affinity
  • b. Low intrinsic activity and low affinity
  • c. High intrinsic activity and low affinity
  • d. No intrinsic activity and high affinity

Question 15

Question
All of the following statements are true regarding the occupation theory of drug-receptor interaction EXCEPT:
Answer
  • a. The affinity of a drug is dependent on its intrinsic activity
  • b. The maximum effect of a drug occurs when all receptors are occupied
  • c. An antagonist has affinity for the receptor but not intrinsic activity
  • d. The magnitude of the effect of a drug is proportional to the number of receptors occupied
  • e. It follows the law of mass action

Question 16

Question
The occupational theory of drug-receptor interaction states that a. The magnitude of the drug response is proportional to the number of receptors occupied b. A partial agonist has intrinsic activity but no affinity for the receptor site c. An antagonist drug has affinity but no intrinsic activity d. The rate at which the drug-receptor complex associates and dissociates determines drug efficacy e. The degree of drug action is dependent on the law of mass action
Answer
  • a) (a), (b) and (c)
  • b) (a), (c) and (e)
  • c) (b), (c) and (d)
  • d) (b) and (e)
  • e) (c), (d) and (e)
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