11976586
Beschreibung
Mindmap von Gelöschter Nutzer, aktualisiert more than 1 year ago
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Erstellt von Plymouth Med
vor mehr als 6 Jahre
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Kopiert von Plymouth Med
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Innate Immunity :)
- Physical Barriers
- Skin
- Mucosa
- Acidic pH
- Tears
(antiseptic)
- Cilia
- Enzymes
- Microcidal
molecules
- Skin
- First Line
Defense
- Normal Microbial
Flora
- Serum
Proteins
- Complement
(Cascade)
- Classical
- Antigen-Antibody
- More common
one
- More common
one
- Antigen-Antibody
- Alternative
- Spontaneous
- Ex: Bacterial
Toxins
- Ex: Bacterial
Toxins
- all 3 lead to C3
convertsase
- Cleaves
- C3a
- anaphalotoxin
- Mast cell
degranulation
- Release
Histamine
- Increased
Vasodilation
- Increased
Vasodilation
- Release
Bradykinin
- Increased Vascular Permeability
- Rolling Adhesion of
Leukocytes
- Vasodilation
- blood flow slows
down
- allows
monocytes to
roll along
epithelial edges
- allows
monocytes to
roll along
epithelial edges
- Vasodilation
- S
- S
- S
- S
- S
- S
- Selectins
- Binds to glycoproteins
on leukocyte to slow it
down
- Binds to glycoproteins
on leukocyte to slow it
down
- I
- I
- I
- I
- I
- I
- Integrins
- Activated by neutrophil
activation
- Stops
monocyte
- Activated by neutrophil
activation
- I
- L
- L
- L
- L
- L
- Diapedesis
- macrophage
goes
into
the
epithelium
to
site
of
injury
- macrophage
goes
into
the
epithelium
to
site
of
injury
- Diapedesis
- L
- L
- L
- Leukocyte
- L
- S
- epithelium
- IL-1
- TNF alpha
- Chemokines increases adhesiveness of epithelial
cells
- TNF alpha
- IL-1
- Pathogen
- Break in
Epithelium
- IL-8 released
- chemotaxis
- leukocytes come
over
- 1.
Neutrophils
- 2. Antigen Presenting
Cells
- Dendritic
Cells
- Macrophages
- Go off to lymph node to present
antigen
- Start of Acquired
Immunity
- Start of Acquired
Immunity
- Dendritic
Cells
- 2. Antigen Presenting
Cells
- 3. Natural Killer Cells
- Detects clumps
of bacteria
- Clumping due
to antibodies
- Clumping due
to antibodies
- Detects clumps
of bacteria
- 1.
Neutrophils
- leukocytes come
over
- chemotaxis
- Prostaglandins released
- IL-8 released
- Rolling Adhesion of
Leukocytes
- Increased Vascular Permeability
- Release
Histamine
- Promotes
Inflammation
- Loss of
functionality
- Swelling
- Pain
- Heat
- Heat
- Redness
- Pain
- Swelling
- Loss of
functionality
- Mast cell
degranulation
- anaphalotoxin
- C3b
- Leads to cleaving of
C5
- C5a
- C5b
- C5b-9
- Membrane Attack Complex
(MAC)
- Membrane Attack Complex
(MAC)
- C5b-9
- C5a
- Complement
- Opsonin
- Coats
bacteria
- Enhances
chemotaxis and
phagocytosis
- Enhances
chemotaxis and
phagocytosis
- Coats
bacteria
- Opsonin
- Leads to cleaving of
C5
- C3a
- Cleaves
- Spontaneous
- Mannase-Binding
Lectin
- Interact with bacteria
directly
- Interact with bacteria
directly
- Classical
- Complement
(Cascade)
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