Zusammenfassung der Ressource
NAFLD
- Anatomy of the liver
- Histology of the liver
- Lipid Metabolism
- A. Transport of acetyl COA
into cytosol B. Carboxylation
of acetyl COA C. Assembly
of FA chain
- Nonalcoholic fatty liver disease (NAFLD) is a
condition in which excess fat is stored in the liver
with the absence of significant alcohol intake.
- Risk factors
- Obesity, Diabetes Mellitus,
Hypertriglyceridemia,
Surgery (Jejunoileal
Bypass), Medications
(Corticosteroids,
Estrogens, Amiodarone),
Exposures to organic
solvents.
- Signs &
Symptoms
- Elevation of serum transaminases, fatigue,
malaise, right upper quadrant discomfort.
- Most are asymptomatic
- Causes
- Metabolic syndrome
- defined as having
at least two of the
following: obesity,
insulin resistance,
dyslipidemia, and
hypertension
- Investigation
- Waist to hip ratio (WHR)
- Physical examination
- Complete blood count
- Lipid profile
- AST and ALT enzymes
- X-Ray of abdomen
- Complications
- cirrhosis, liver failure, liver cancer,
edema and ascites, hepatic encephalopathy,
hepatorenal syndrome, hepatopulmonary
syndrome, hypersplenism, bacterial peritonitis.
- Management
- Pharmacological
- Orlista, Lorcaserin, phentermine-topiramate, Liraglutide.
- Bariatric surgery
- Affected
by
- Types of Diets
- Atkins Diet
- Nutrisystem Diet