Mindmap
Viral immune response
Inhalt der Mindmap
Viral immune response
Viral infection targets epithelial cells
- Epithelial cells release cytokines
- Interferon alpha
- Signals to other cells that there is a viral infection
- Prevents the virus from replicating in cells
- If the virus resists the cytokines, it enters the tissue
- Virus recognised by phagocytes
- Macrophage binds to surface of infected cell and engulfs it
- Macrophage releases cytokines
- Activates mast cells
- Mast cells contain granules
- Granules contain enzymes and active components that have an effect on endothelial cells lining the blood vessels
- Blood vessels become leaky as gap junctions are damaged
- Blood and interstitial fluid enters tissue
- Neutrophils drawn into area
- C Reactive Protein drawn into area
- Complement drawn into area
- Some resident cells broken down by virus
- Particulates of virus in cellular debris and tissue
- Dendritic cells pick up viral particles
- Taken to local lymph node
- Talks to naive T cells
- Adaptive immune system
- Uses MHC2 protein
- Naive T cell activated
- Undergoes clonal expansion
- All T cells fight off specific infection
- Differentiate
- Cytotoxic T cell
- T helper cell
- Undergoes clonal expansion
- TH1 mediated response
- Intracellular infection
- Cell mediated response
- Some B cells activated
- Memory cells
- Plasma cells
- Antibodies
- Macrophages activated
- Release interferon gamma and interleukin 2
- Activate CD8 T cells
- Activates cytotoxic T cells
- Travel to site of infection
- Recognise MHC1 protein on virally infected cells
- Kills virally infected cells
- Death signal
- Fas protein on surface of infected cell
- Binds to Fas ligand protein on cytotoxic T cell
- Signal transduction enters virally infected cell
- Activates different proteins and enzymes
- Cell undergoes apoptosis
- Signals on surface cause it to be engulfed by phagocytes
- Virus and infection removed
- Normality restored
- Virus and infection removed
- Signals on surface cause it to be engulfed by phagocytes
- Cell undergoes apoptosis
- Activates different proteins and enzymes
- Signal transduction enters virally infected cell
- Binds to Fas ligand protein on cytotoxic T cell
- Fas protein on surface of infected cell
- Release of enzymes
- Cytotoxic T cells release perforin
- Punches holes in virally infected cell
- Granzymes enter cell
- Break down DNA and cellular machinery in infected cell
- Cell undergoes apoptosis
- Break down DNA and cellular machinery in infected cell
- Granzymes enter cell
- Punches holes in virally infected cell
- Cytotoxic T cells release perforin
- Death signal
- Kills virally infected cells
- Recognise MHC1 protein on virally infected cells
- Travel to site of infection
- Activates cytotoxic T cells
- Activates NK cells
- Recognise cells that are missing MHC1
- Some viruses stop host cells from using MHC protein flagging system to alert other cells of infection
- Kills virally infected cells
- Death signal
- Release of enzymes
- Release interferon gamma
- Activates macrophages
- Macrophages release interleukin 12
- Activates macrophages
- Recognise cells that are missing MHC1
- Activate CD8 T cells
- Talks to naive T cells
- Taken to local lymph node
- Dendritic cells pick up viral particles
- Particulates of virus in cellular debris and tissue
- Blood and interstitial fluid enters tissue
- Blood vessels become leaky as gap junctions are damaged
- Granules contain enzymes and active components that have an effect on endothelial cells lining the blood vessels
- Mast cells degranulate and release granules into surrounding tissue
- Mast cells contain granules
- Activates mast cells
- Macrophage releases cytokines
- Macrophage binds to surface of infected cell and engulfs it
- Virus recognised by phagocytes
- Interferon alpha
- Infected cell presents small viral particle on MHC1 molecule
- Epithelial cells release cytokines
Informationen
- Beschreibung
- Mindmap am Viral immune response, erstellt von Hattie Warr am 06/03/2018.
- Erstellt von
- Hattie Warr
- Aufrufe
- 19
- Bewertung