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Noses

Beschreibung

Mindmap am Noses, erstellt von HY YIP am 24/10/2014.
HY YIP
Mindmap von HY YIP, aktualisiert more than 1 year ago
HY YIP
Erstellt von HY YIP vor etwa 11 Jahre
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Zusammenfassung der Ressource

Noses
  1. Structure
    1. Sinus
      1. Mucus formed and filled up
      2. Olfactory bulb
        1. Main site of smelling
        2. Turbinate
          1. Main site of drug absorption
            1. Contain lots of folds, large surface area
            2. Cilia
              1. Rymthmic beating action
                1. drain mucus away from the nose
                  1. Defence against infection, toxins and allergens
                    1. on turbinate
                  2. Connect the ears and mouth
                    1. infection in nose/lungs may affect ears and mouths
                  3. Fuction
                    1. Breathing
                      1. smelling
                      2. Benefits of nasal drug delivery
                        1. Avoid passing BBB
                          1. BBB requires lipophilic drug to pass through
                            1. A special circulatory system
                              1. Allow delivery of hydrophilic drug
                            2. Avoid metabolised by the liver
                              1. contains enzyme that might degraded drugs
                              2. new forms and drug/ vaccine delivering
                                1. user friendly
                                  1. less pain
                                  2. Application
                                    1. localized
                                      1. systematic
                                      2. Dosage form flexibility
                                      3. Factor affect nasal dosage form
                                        1. Nasal metabolism
                                          1. Nose has a first metabolic rate
                                          2. illness
                                            1. Extra mucus produce
                                            2. physical barrier
                                              1. Mucus
                                              2. resistance time/ clearance
                                                1. pH
                                                  1. pKa should be match with nose
                                                  2. particle size
                                                    1. too big
                                                      1. Stuck in outside of nose
                                                      2. too small
                                                        1. Go down the lungs
                                                    Zusammenfassung anzeigen Zusammenfassung ausblenden

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