Structure and function in proteins

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Structure and function in proteins
  1. Globular Proteins
    1. Haemoglobin
      1. Ball shaped molecule
        1. Soluble in water
          1. Contains many R groups containing hydrophilic side chains on the outside of the 'ball'
        2. Insulin
          1. Shape allows it to form bonds with other protein molecules
            1. In the membranes of liver cells
              1. Complementary shape
                1. Respond by setting off a sequence of events
                  1. Culminates in the joining of glucose molecules to cause glycogen
          2. Enzymes
            1. Active site
              1. Precise shape that allows the enzyme to bind with other molecules
                1. Causing a reaction
          3. Fibrous Proteins
            1. Long, thin, molecules
              1. Keratin
                1. Found in hair, wool, nails and skin
                  1. Keratin forms long molecules that coil
                    1. These associate with each other
                      1. To form filaments
                        1. Very strong
                          1. Held together by disulphide bridges
                  2. Chains of amino acids
                    1. Regular pattern of hydrogen bonds
                      1. Causes them to coil into long helices
                    2. Insoluble
                      1. Structural roles
                      2. Collagen
                        1. Gives bone and cartilage strength
                          1. 3 twisted polypeptide chains
                            1. More tightly bound than Keratin
                              1. Can form more rigid structures
                                1. Often grouped together to from almost rigid rods
                        2. Simple Protein Strucutre
                          1. Primary Structure
                            1. Secondary Strucutre
                              1. Tertiary Structure
                                1. Quaternary Structure
                                  1. The function of a protein depends on its 3D shape.
                                2. The 3D shape is determined by its primary structure
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