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PHARMACOLOGICAL ASPECTS OF HYPOTHALAMUS / PITUITARY & ADRENAL DISORDERS

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Mindmap am PHARMACOLOGICAL ASPECTS OF HYPOTHALAMUS / PITUITARY & ADRENAL DISORDERS, erstellt von Zulhilmi Zainal am 14/04/2014.
Zulhilmi Zainal
Mindmap von Zulhilmi Zainal, aktualisiert more than 1 year ago
Zulhilmi Zainal
Erstellt von Zulhilmi Zainal vor mehr als 12 Jahre
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Zusammenfassung der Ressource

PHARMACOLOGICAL ASPECTS OF HYPOTHALAMUS / PITUITARY & ADRENAL DISORDERS
  1. physiology
    1. Growth Hormone
      1. somatropin,somatrem(synthetic analog)
        1. To improve growth in children with GH deficiency
          1. Adverse
            1. Carpal tunnel syndrome, hyperglycemia
            2. Somatostatin
              1. Somatotropin releasing inhibiting hormone
                1. Synthetic
                  1. 1 Octreotide 2 Pegvisomant
                    1. uses
                      1. Acromegaly. Carcinoid tumors. Pancreatic tumors
                      2. Adverse
                        1. sludge(gallstone)
                  2. ERGOT DERIVATIVES (DOPAMINE AGONIST (D2)
                    1. Decrease prolactin
                      1. Bromocriptine
                        1. USES
                          1. Hyperprolactinemia
                            1. Parkinsonism
                            2. effecs
                              1. syncope,postural hypotension, psychosis
                            3. Vassopressin
                              1. ADH
                                1. Uses
                                  1. Neurogenic DI(pituitary)(central DI)
                                    1. Nephrogenic DI(impaired renal response to AVP)
                                      1. Constrict blood vessel
                                      2. Adverse
                                        1. coronary vasospasm
                                          1. uterine contraction
                                        2. Desmopressin
                                          1. selective (V2) agonist
                                            1. Uses
                                              1. DI(Central,pituitary)(DOC) Bedwetting(children)
                                            2. Adenocorticosteroids
                                              1. MAGIC drug
                                                1. Synthesis
                                                  1. uses
                                                    1. ALL Disease usable
                                                      1. Neurologic diseases
                                                        1. Pulmonary diseases
                                                          1. Renal disease
                                                      2. Immunosuppression
                                                        1. TOXICITY
                                                          1. Acute withdrawal
                                                            1. cerebral edema
                                                              1. fever, myalgia
                                                              2. Prolonged usage
                                                                1. fluid/lyte disturbances, hypertension, hyperglycemia, glycosuria
                                                                  1. peptic ulcers, osteoporosis (direct inhibition of osteoblasts) myopathy, cataracts

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