PHSI3012 09-1 Atherothrombosis

Fibrin generation at the site of vascular injury has a crucial role in anchoring the thrombus to the vessel. It requires initiation of coagulation and generation of thrombin. This depends on Tissue Factor (TF) expression on the surface of Smooth Muscle Cells (SMCs) Vascular Endothelial Cells (VECs) Vascular Epithelial Cells (VECs) Skeletal Muscle Cells (SMCs) Cardiac Muscle Cells (CMCs)( Smooth Muscle Cells (SMCs), Vascular Endothelial Cells (VECs), Vascular Epithelial Cells (VECs), Skeletal Muscle Cells (SMCs), Cardiac Muscle Cells (CMCs) ) and fibroblasts.

Which of the following are prothrombotic and which are antithrombotic?
ADP: Pro Anti( Pro, Anti );
Aspirin: Anti Pro( Anti, Pro );
Epinephrine: Pro Anti( Pro, Anti );
Clopidogrel: Anti Pro( Anti, Pro );
Collagen: Pro Anti( Pro, Anti );
Heparin: Anti Pro( Anti, Pro );
Thrombin: Pro Anti( Pro, Anti );