General clinical manifestations

Vary according to the type of defect
Careful H & P
Bleeding may be superficial or deeper within the body
Petechiae
- With platelet factor abnormality
Risk factors for bleeding (Chart 33-6)
- Severity/duration of thrombocytopenia
- Sepsis ( high platelet consumption)
- Increased intracranial pressure (rupture vessels; causes bleeding)
- Liver (coagulation factors) /renal dysfunction (erythropoietin)
- Dysproteinemia – low platelet function
- Alcohol abuse – low platelet production
- Splenomegaly – high platelet destruction
- Medications