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Ludwig's Angina
Anti-Infection
Agents
Antibacterial
Agent
Antibiotics
Antimicrobials
Concept of Selective Toxicity
Mechanisms of Selective Toxicity
Unique Drug Targets
Selective Inhibition
Common Targets
Mechanisms of
Antibacterial Action
Abx which affect
Cell Wall Synthesis
Abx that act on Protein Synthesis
Abx that act on
Nucleic Acid Synthesis
Inhibition of Cell Wall Synthesis
Alterations in Cell Membrane
Inhibition of Protein Synthesis
Inhibition of Nucleic Acid Synthesis
Inhibition of Folic Acid Synthesis
Microbial Resistance
Natural Resistance
Acquired Resistane
Enzyme Inactivation
Genetic Mechanisms
Intensity to apoptosis
Superinfections
Antibiotic Therapy
Chemoprophylaxis
Spectrum of Activity
Antibiotic Failure
Bactericidal Bacteriostatic
Antibiotic Adverse Effects
Penicillins
Parenteral Penicillin G/
Oral Penicillin V
Penicillins
Antistaphylococcal Penicillins
Penicillins
Aminopenicillins
Penicillins
Ureidopenicillins
Penicillins
Mechanism of action
Penicillin G (Benzylpenicillin)
Penicillins ADRx
Penicillin Allergy
Penicillin Allergy
Penicillin Anaphylaxis
Penicillins-Drug Interactions
Aminopenicillins
[Ampicillin, Amoxicillin,
Bacampicillin]
Betalactamases: Penicillinase
Penicillin + Beta-lactamase
Inhibitor
Cephalosporins
Cephalosporins
Third Generation Cephalosporins
Fourth Generation
Cephalosporins
Fifth Generation Cephalosporins
Cephalosporins
Adverse Effects
Protein Synthesis Inhibitors
Protein Synthesis Inhibitors
Tetracycline
Macrolides: Erythromycin
Newer Macrolides
Telithromycin
Chloramhenicol
Clindamycin (Cleocin)
Clindamycin ADRx
Pseudomembranous Colitis
Sulfonamides:
Sulfamethoxazole
Bacteriostatic
Sulfonamides-Adverse Effects
Trimethoprim
Bactrim, Septra, Cotrim,
Co-trimoxazole
Nucleic Acid Synthesis Inhibitors
Metronidazole
Adverse Effects
Metronidazole Drug Interactions
Fluoroquinolones
Ciprofloxacin, Norfoxacin,
Levofloxacin
Fluoroquinolones
Ciprofloxacin
What Abx would you use on a
woman during her first
trimester of pregnancy?
Aminoglycosides
Aminoglycosides
Side Effects
MRSA
Methicillin resistant
Staph aureus
VRE
Vancomycin Resistant
Enterococci
VRSA
Vancomycin Resistant
S aureus
STreptogramins
Oxazolidinones
Pleuromutilins
