What IV bolus loading dose would be required if you need to achieve 2mg/L and Vd is 50L?

You are commencing an IV infusion to achieve Css=4mg/L. The clearance of the drug is 10L/h, what would be the required infusion rate?

If you commence an infusion at 40mg/h and the half-life of the drug is 4h, how long until steady-state plasma drug concentration is achieved?

The plasma drug concentration of a drug after an IV bolus is 10ng/mL 4h after dosing and it is 5ng/mL 8h after dosing. What is k? what is elimination half-life?

If Vd=50L and k=0.1h-1, what is CL?

If we administer an IV bolus dose of 500mg and collect urine so we collect all drug that is excreted unchanged and the amount collected = 300mg, what is the fraction excreted unchanged?

if we administer an oral dose of 500mg and F=0.8 and we collect all urine so that we determine that 100mg is excreted unchanged, what is fraction excreted unchanged (fe)?

A patient is receiving 250mcg digoxin daily and the bioavailability of tablet is 0.7. At steady-state the Cssav= 1ng/mL, what is the clearance of the drug in this patient?

If patient is receiving 125mcg digoxin tablets orally daily and F=0.7 and CL=2L/h, what would be the Cssav achieved?

If a patient is taking a 250mcg Digoxin tablet daily which has oral bioavailability of 0.6 and is now to be swapped to digoxin elixir (50mcg/mL) which has a bioavailability of 0.8, how many mL of digoxin elixir would be the appropriate dose?