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Comprehensive Review questions compiled by turknO_ for leggomed

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BIOCHEMISTRY: Intermediate metabolism

Frage 1 von 20

1

A low level of carbon dioxide labeled with 14C is accidentally released into the atmosphere surrounding industrial workers as they resume work following the lunch hour. Unknowingly, they breathe the contaminated air for 1 hour. Which of the following compounds will be radioactively labeled?

Wähle eine der folgenden:

  • All of the carbon atoms of newly synthesized fatty acid.

  • About one half of the carbon atoms of newly synthesized fatty acids.

  • The carboxyl atom of newly synthesized fatty acids.

  • About one third of the carbons of newly synthesized malonyl CoA.

  • One half of the carbon atoms of newly synthesized acetyl CoA.

Erklärung

Frage 2 von 20

1

A teenager, concerned about his weight, attempts to maintain a fat-free diet for a period of several weeks. If his ability to synthesize various lipids were examined, he would be found to be most deficient in his ability to synthesize:

Wähle eine der folgenden:

  • Triacylglycerol

  • Phospholipids

  • Cholesterol

  • Sphingolipids

  • Prostaglandins

Erklärung

Frage 3 von 20

1

A 44-year-old man displayed elevated cholesterol levels and was prescribed a statin to reduce such levels. Statin treatment has the potential to interfere with the synthesis of which of the following?

Wähle eine der folgenden:

  • Heme

  • Dihydrobiopterin

  • Ketone bodies

  • Coenzyme Q

  • Glycogen

Erklärung

Frage 4 von 20

1

A 12-year-old female presented with severe abdominal pain and was found to have a markedly elevated plasma triglyceride concentration (750 mg/dL). A lipoprotein analysis revealed elevated levels of chylomicrons and VLDL and reduced levels of HDL. Which protein might be defective in this patient?

Wähle eine der folgenden:

  • ApoCII

  • ApoB100

  • ApoE

  • Pancreatic lipase

  • LCAT

Erklärung

Frage 5 von 20

1

Statins are ineffective in lowering cholesterol levels in individuals with homozygous familial hypercholesterolemia due to which of the following?

Wähle eine der folgenden:

  • HMG-CoA reductase is resistant to statins

  • Statins cannot enter the liver cells

  • LDL receptors are nonfunctional

  • Reverse cholesterol transport is inoperative in these patients

  • LCAT is resistant to statin action

Erklärung

Frage 6 von 20

1

An adult male should have HDL levels equal to or greater than 40 mg/dL. A necessary enzyme contributing to HDL’s protective effect is which of the following?

Wähle eine der folgenden:

  • CETP

  • LCAT

  • ACAT

  • AMP-activated protein kinase

  • Protein kinase A

Erklärung

Frage 7 von 20

1

You have placed a patient on Pravachol pravastatin to reduce her cholesterol. This class of drugs is effective due to a direct inhibition of which of the following?

Wähle eine der folgenden:

  • HMG-CoA synthase

  • HMG-CoA reductase

  • Carnitine acyltransferase 1 (CAT-1)

  • Citrate lyase

Erklärung

Frage 8 von 20

1

A child has been diagnosed with Tay–Sachs disease, in which a particular lipid accumulates within the lysosomes. The component of this lipid which cannot be removed in the lysosome is which of the following?

Wähle eine der folgenden:

  • Sphingomyelin

  • Ceramide

  • Fatty acid

  • Glucose

  • N-acetylgalactosamine

Erklärung

Frage 9 von 20

1

Glutathione is a constituent of

Wähle eine der folgenden:

  • Leukotriene A4

  • Leukotriene C4

  • Thromboxane A1

  • None of these

Erklärung

Frage 10 von 20

1

Cyclo-oxygenase is involved in the synthesis of

Wähle eine der folgenden:

  • Prostaglandin

  • Thromboxane

  • Prostaglandin and thromboxane

  • Leukotriene

Erklärung

Frage 11 von 20

1

Esters of fatty acids with higher alcohols other than glycerol are said to be

Wähle eine der folgenden:

  • Waxes

  • Fats

  • None of these

  • Oils

Erklärung

Frage 12 von 20

1

Carnitine is synthesized from

Wähle eine der folgenden:

  • Lysine

  • Serine

  • Choline

  • Arginine

Erklärung

Frage 13 von 20

1

A patient has been diagnosed with abetalipoproteinemia. A possible deficiency in which of the following vitamins could occur in this patient?

Wähle eine der folgenden:

  • Vitamin B1

  • Vitamin B2

  • Niacin

  • Vitamin C

  • Vitamin E

Erklärung

Frage 14 von 20

1

Which one of the fatty acids listed below can be synthesized by humans?

Wähle eine der folgenden:

  • Cis Δ9, 12 C18:2

  • Cis Δ9, 12, 15 C18:3

  • Cis Δ5, 8, 13 C20:3

  • Cis Δ5, 8, 11, 14 C20:4

  • Cis Δ10 C16:1

Erklärung

Frage 15 von 20

1

You are treating a patient with a fat malabsorption problem, and you suggest that the patient switch his or her diet to one that contains which of the following?

Wähle eine der folgenden:

  • Triglycerides with long-chain fatty acids

  • Triglycerides with medium-chain fatty acids

  • Triglycerides with short-chain fatty acids

  • Triglycerides with a mixture of long-chain and short-chain fatty acids

  • Triglycerides with a mixture of long-chain and medium-chain fatty acids

Erklärung

Frage 16 von 20

1

Treatment of dyslipidemia may involve giving the patient one of these

Wähle eine der folgenden:

  • Niacin

  • Lovastatin

  • Vitamin E

  • Mevastatin

Erklärung

Frage 17 von 20

1

The above prescription works by

Wähle eine der folgenden:

  • Lowering serum LDL levels

  • Lowering levels of VLDL and raises levels of HDL

  • Raising LDL levels

  • Increasing bile acids synthesis

  • Inhibiting HMG CoA reductase activity

Erklärung

Frage 18 von 20

1

The exchange of cholestrol esters for triacylglycerols between HDLs and VLDLs is catalysed by

Wähle eine der folgenden:

  • LCAT

  • CETP

  • ACAT

  • Lipoprotein lipase

Erklärung

Frage 19 von 20

1

Tay-Sachs is to hexosaminidase as Gaucher is to__________

Wähle eine der folgenden:

  • Glucocerebrosidase

  • Sphingomyelinase

  • Alpha-galactosidase

  • Arylsulphatase A

Erklärung

Frage 20 von 20

1

Non-liver and Non-intestine cells get cholesterol from the plasma, rather than synthesizing it de novo from LDL

Wähle eins der folgenden:

  • WAHR
  • FALSCH

Erklärung