Explain the concept of drug distribution within the body

Where else in the body may the drug end up apart from target tissue?

What is meant by the phrase 'bound drug'?

What is the formula to calculate volume of distribution?

What does volume of distribution tell you?

Why can the volume of distribution be so high in comparison to the volume in specific compartments?

What is drug distribution?

What are the major compartments in the body that drugs may be distributed to?

What are most drugs able to do?

Explain the process of protein binding

What does the efficacy of a drug depend upon?

When are drugs active?

What is usually established between the bound and free forms of a drug?

What three things are true for the bound drug as a result of it being retained in the circulatory system?

Why may there be competition between drugs for protein binding?

What is the difference between Warfarin and phenytoin?

Stopping or starting a drug that binds to a protein changes the level of other drugs that bind to that same protein. Explain how using Warfarin and phenytoin as an example

Even when there is the free drug it's ability to have an effect on their target is dependent on...

What are the four different types of receptor?

Describe the structure of G-protein coupled receptors

How can these 7 spanning domains be refined even further?

Explain how G-protein coupled receptors (GPCR) work

Explain how GPRCs work in terms of GDP (Guanine diphosphate) and GTP (Guanine triphosphate)

What are RGSs used for?

Explain how ligand gated ion channels work

When ligand gated ion channels are activated the membrane potential is affected. What are the two possible results of this?

Explain how receptor tyrosine kinases work

When are nuclear receptors used?

How are nuclear receptors made even more inactive?

Explain how nuclear receptors work

Give two examples of lipid soluble hormones

How long do the different receptors take in comparison to each other?

Comment on the difference and similarity between tachyphylaxis and tolerance

Explain five different mechanisms for tachyphylaxis/tolerance

Give one example of tachyphylaxis