What is addiction?

Addiction is complex

hedonic value

positive-incentive value

ABC

Drugs with addictive potential

mesocorticolimbic DA-pathway

Stimulant Drugs

Symptoms of acute stimulant use

Stimulants work as dopamine agonists

DA transporters

injecting cocaine is reinforcing

injecting cocaine is reinforcing

speed of drug maximum concentration and half-life

Speed of drug maximum concentration and half-life

tolerance & wtihdrawal mark physical dependence

withdrawal

tolerance

withdrawal

common withdrawal symptoms

drug tolerance lowers a drug's effect

"Upping" the dose is riskly...

Chart of "upping the dose"

"Upping" the dose is risky...

Allostasis: withdrawal & tolerance effects

Shift of allostasis

negative reinforcement