How is self tolerance generated?

What four criteria to autoimmune diseases follow?

What is experimental autoimmune encephalomyelinitis (EAE)?

What is autoimmunity?

What gender are autoimmune diseases more prevalent with?

Where does T-cell tolerance occur

How does positive selection of T-cells occur?

How does negative selection of T-cells occur?

Why is thymic education only partially successful?

What occurs in mutations of AIRE (genes which expresses self-proteins in the thymus)?

Where does central B-cell tolerance occur?

What happens to multivalent self molecules?

What happens to low affinity self reacting b-cells?

What happens in somatic hypermutation of the peripherary?

What occurs in peripheral tolerance?

What is immunological ignorance?

What is anergy?

What happens to anergic cells?

How are co-stimulatory signal molecules regulated?

Where does interaction with Naive t-cells usually occur?

What is suppression?

How do CD4+ and CD25+ cells supress?

When CD4+ and CD25+ molecules are given to animal participants what diseases ameliorate?

How is tolerance broken down?

What happens when the tolerance barrier is broken?

Name an example of post-translational modification?

When does citrullemination occur?

In which diseases is citrullination seen?

What is molecular mimicry?

When does molecular mimicry occur?

Give an example of molecular mimicry?

What is epitope spreading?

Name an example of epitope spreading?

Do genetic factors contribute to autoimmune diseases?

What are the strongest genetic associations?

What mechanisms lead to autoimmune diseases?

How does tissue damage lead to autoimmune disease?

How do auto-immune antibodies lead to disease?

What is systemic lupus erythematosus (SLE)?

What does SLE result in?

What are the pathological changes in SLE?

Are antibodies cause or consequence of SLE?

What is Multiple Sclerosis (MS)?

What is the incidence of MS?

What are the symptoms of MS?

What is the major hallmark of MS?

What causes MS?

What happens during the inflammatory phase in MS?

How is MS diagnosed?

What is the anti-nuclear antibody test (ANA)?

Why is the staining in ANA's important?

What staining patterns are seen in SLE?

What staining pattern is seen in Sharp syndrome?

What staining is seen is Sjogrens Syndrome?