Pharmaceutics I

Frage 1 von 25

1

By the definitions from out notes for disperse systems, “Generally, a liquid preparation in which a
finely divided, insoluble or immiscible material is distributed throughout a vehicle”, what is the
minimum number of phases present in a dispersed system?

Wähle eine der folgenden:

1
2
3

Erklärung

Frage 2 von 25

1

The distinction between the terms coarse, fine, colloidal dispersion is based upon what property of
the dispersed phase?

Wähle eine der folgenden:

Solid state
Particle size
Molecular weight
Chemical structure

Erklärung

Frage 3 von 25

1

Why might a dispersed phase containing drug be formulated in a dispersion medium in which it
was insoluble?

Wähle eine der folgenden:

To increase the solubility
To mask bitter tastes
To increase the viscosity
To decrease the viscosity
None of the above

Erklärung

Frage 4 von 25

1

Given the equation for Stoke’s law of settling below, by how much you have to increase the
viscosity to offset a particle size increase of a factor of two?

Wähle eine der folgenden:

Factor of 1/2
Factor of 2
Factor of 4

Erklärung

Frage 5 von 25

1

Given a suspension with a fixed particle size distribution, what would be true if each powder
particle displaced its own weight of dispersing phase (i.e. density of dispersed phase = density of
dispersion medium)?

Wähle eine der folgenden:

The viscosity would be infinite
The settling rate will be very high
The settling rate would be zero
The particle size would approach colloidal dimensions

Erklärung

Frage 6 von 25

1

The primary mechanism of altering dispersion medium properties is modification of:

Wähle eine der folgenden:

Density
Viscosity
Dielectric constant

Erklärung

Frage 7 von 25

1

Which of the following characteristics is NOT desirable in the case of suspension dosage forms?

Wähle eine der folgenden:

Flocculation with formulation of loosely bound aggregates
Flocculation with formulation of strongly bound aggregates
Formation of loose sediment

Erklärung

Frage 8 von 25

1

An advantage of a shear thinning formulation includes:

Wähle eine der folgenden:

Ease of mixing with relatively mild shaking of the container
Lower viscosity on standing to prevent settling
Caking of needle shaped particles

Erklärung

Frage 9 von 25

1

Under what conditions would you compound a suspension using benzyl alcohol or propylene
glycol for preemies?

Wähle eine der folgenden:

Only for acute usage
Only for antibiotics
Never

Erklärung

Frage 10 von 25

1

You are asked to compound a suspension of a drug normally dispensed as a solid dosage form.
Why is it prudent to determine if a liquid dosage form is also commercially available?

Wähle eine der folgenden:

You can save the effort and advise the patient they must wait until you can order the
commercial dosage form
If a commercial liquid dosage form isn’t available, it may indicate a potential chemical
stability problem
If a commercial liquid dosage form isn’t available, it may indicate a potential physical
stability problem
Both B and C

Erklärung

Frage 11 von 25

1

Select the choices that correctly fill the blanks in the following statement: the three minimum
requirements (i.e., 3 rules) needed for form a stabilized emulsion are 1) 2) 3).

Wähle eine der folgenden:

1) Components forming at least 2 phases, 2) a component to stabilize the interface between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.
1) At least one solid component 2) amphiphilic surfactant molecules, 3) adjustment to physiologic pH
1) Component forming liquid crystalline phases, 2) a component to overcome the “double layer between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.
All of the above

Erklärung

Frage 12 von 25

1

Which of the following statements is NOT a valid criterion for suspecting an emulsion is physically
unstable?

Wähle eine der folgenden:

Dispersed phase tends to form aggregates of globules on standing
Aggregates of the dispersed phase may be re-dispersed by shaking
Large globules or aggregates of globules rise to the top or fall to the bottom of container forming a concentrated layer of dispersed phase
All or part of the liquid in the dispersed phase separates to form a distinct layer

Erklärung

Frage 13 von 25

1

Patients should virtually never be instructed to store an emulsion dosage form:

Wähle eine der folgenden:

In the refrigerator
At room temperature
In the freezer

Erklärung

Frage 14 von 25

1

The HLB system is primarily useful for matching a non-ionic surfactant system with the oil phase
in an emulsion. Given that: HLB Span 60 = 4.7, and HLB of Tween 60 = 14.9 estimated fraction of
Span 60 and Tween 60 needed to achieve an HLB of 12 is approximately (to the nearest %):

Wähle eine der folgenden:

72 and 28% respectively
28 and 72% respectively
None of the above

Erklärung

Frage 15 von 25

1

A magma is a:

Wähle eine der folgenden:

Two phase gel in which the gel mass does not consists of floccules of small distinct particles
One phase gel in which the gel mass consists of floccules of small distinct particles
Two phase gel in which the gel mass consist of floccules of small distinct particles

Erklärung

Frage 16 von 25

1

In a colloidal dispersion the particle size is:

Wähle eine der folgenden:

Much smaller than typical molecule dimensions
Much larger than typical molecule dimensions
The same or smaller than typical molecule dimensions

Erklärung

Frage 17 von 25

1

Which of following is FALSE in case of gel formulation exhibiting syneresis?

Wähle eine der folgenden:

A measurable increase in volume of Gel
A non-measurable change in the volume of Gel
A measureable decrease in volume of Gel
A and B
B and C

Erklärung

Frage 18 von 25

1

What is a major function of glycerin in the carboxymethylcellulose based gel formulations?

Wähle eine der folgenden:

To prevent drying of Gel
Sweetner
Antioxidant

Erklärung

Frage 19 von 25

1

Which of following if true of aerosol used to provide an airborne mist?

Wähle eine der folgenden:

Particle size >50μm
Particle size <50 μm
Particle size <1μm
None of above

Erklärung

Frage 20 von 25

1

A properly prepared pharmaceutical suspension should settle slowly and should readily re
dispersed upon gentle shaking on the container

Wähle eins der folgenden:

WAHR
FALSCH

Erklärung

Frage 21 von 25

1

Which of the following excipients should not be used in the formulation of a Carboxymethylcellulose-based gel?

Wähle eine der folgenden:

Preservative
Glycerin
Alcohol
None of the above

Erklärung

Frage 22 von 25

1

Stability is an important consideration in the formulation of emulsions. Which of the following represents an irreversible phenomenon in terms of re-dispersion of emulsion?

Wähle eine der folgenden:

Creaming
Coalescence of droplets
Flocculation
None of the above

Erklärung

Frage 23 von 25

1

Given that the API is soluble in water, which of the following type of emulsion is desirable to formulate?

Wähle eine der folgenden:

O/W
W/O
None of the above

Erklärung

Frage 24 von 25

1

	Erstellt von Jon dL vor etwa 7 Jahre

Quiz am Pharmaceutics I, erstellt von Jon dL am 07/03/2017.

Pharmaceutics I

Frage 1 von 25

By the definitions from out notes for disperse systems, “Generally, a liquid preparation in which a finely divided, insoluble or immiscible material is distributed throughout a vehicle”, what is the minimum number of phases present in a dispersed system?

Wähle eine der folgenden:

Erklärung

Frage 2 von 25

The distinction between the terms coarse, fine, colloidal dispersion is based upon what property of the dispersed phase?

Wähle eine der folgenden:

Erklärung

Frage 3 von 25

Why might a dispersed phase containing drug be formulated in a dispersion medium in which it was insoluble?

Wähle eine der folgenden:

Erklärung

Frage 4 von 25

Given the equation for Stoke’s law of settling below, by how much you have to increase the viscosity to offset a particle size increase of a factor of two?

Wähle eine der folgenden:

Erklärung

Frage 5 von 25

Given a suspension with a fixed particle size distribution, what would be true if each powder particle displaced its own weight of dispersing phase (i.e. density of dispersed phase = density of dispersion medium)?

Wähle eine der folgenden:

Erklärung

Frage 6 von 25

The primary mechanism of altering dispersion medium properties is modification of:

Wähle eine der folgenden:

Erklärung

Frage 7 von 25

Which of the following characteristics is NOT desirable in the case of suspension dosage forms?

Wähle eine der folgenden:

Erklärung

Frage 8 von 25

An advantage of a shear thinning formulation includes:

Wähle eine der folgenden:

Erklärung

Frage 9 von 25

Under what conditions would you compound a suspension using benzyl alcohol or propylene glycol for preemies?

Wähle eine der folgenden:

Erklärung

Frage 10 von 25

You are asked to compound a suspension of a drug normally dispensed as a solid dosage form. Why is it prudent to determine if a liquid dosage form is also commercially available?

Wähle eine der folgenden:

Erklärung

Frage 11 von 25

Select the choices that correctly fill the blanks in the following statement: the three minimum requirements (i.e., 3 rules) needed for form a stabilized emulsion are 1) ____ 2)____ 3)____.

Wähle eine der folgenden:

Erklärung

Frage 12 von 25

Which of the following statements is NOT a valid criterion for suspecting an emulsion is physically unstable?

Wähle eine der folgenden:

Erklärung

Frage 13 von 25

Patients should virtually never be instructed to store an emulsion dosage form:

Wähle eine der folgenden:

Erklärung

Frage 14 von 25

The HLB system is primarily useful for matching a non-ionic surfactant system with the oil phase in an emulsion. Given that: HLB Span 60 = 4.7, and HLB of Tween 60 = 14.9 estimated fraction of Span 60 and Tween 60 needed to achieve an HLB of 12 is approximately (to the nearest %):

Wähle eine der folgenden:

Erklärung

Frage 15 von 25

A magma is a:

Wähle eine der folgenden:

Erklärung

Frage 16 von 25

In a colloidal dispersion the particle size is:

Wähle eine der folgenden:

Erklärung

Frage 17 von 25

Which of following is FALSE in case of gel formulation exhibiting syneresis?

Wähle eine der folgenden:

Erklärung

Frage 18 von 25

What is a major function of glycerin in the carboxymethylcellulose based gel formulations?

Wähle eine der folgenden:

Erklärung

Frage 19 von 25

Which of following if true of aerosol used to provide an airborne mist?

Wähle eine der folgenden:

Erklärung

Frage 20 von 25

A properly prepared pharmaceutical suspension should settle slowly and should readily re dispersed upon gentle shaking on the container

By the definitions from out notes for disperse systems, “Generally, a liquid preparation in which a
finely divided, insoluble or immiscible material is distributed throughout a vehicle”, what is the
minimum number of phases present in a dispersed system?

The distinction between the terms coarse, fine, colloidal dispersion is based upon what property of
the dispersed phase?

Why might a dispersed phase containing drug be formulated in a dispersion medium in which it
was insoluble?

Given the equation for Stoke’s law of settling below, by how much you have to increase the
viscosity to offset a particle size increase of a factor of two?

Given a suspension with a fixed particle size distribution, what would be true if each powder
particle displaced its own weight of dispersing phase (i.e. density of dispersed phase = density of
dispersion medium)?

Under what conditions would you compound a suspension using benzyl alcohol or propylene
glycol for preemies?

You are asked to compound a suspension of a drug normally dispensed as a solid dosage form.
Why is it prudent to determine if a liquid dosage form is also commercially available?

Select the choices that correctly fill the blanks in the following statement: the three minimum
requirements (i.e., 3 rules) needed for form a stabilized emulsion are 1) 2) 3).

Which of the following statements is NOT a valid criterion for suspecting an emulsion is physically
unstable?

The HLB system is primarily useful for matching a non-ionic surfactant system with the oil phase
in an emulsion. Given that: HLB Span 60 = 4.7, and HLB of Tween 60 = 14.9 estimated fraction of
Span 60 and Tween 60 needed to achieve an HLB of 12 is approximately (to the nearest %):

A properly prepared pharmaceutical suspension should settle slowly and should readily re
dispersed upon gentle shaking on the container