Innate Immunity II

IMMUNE EVASION
1) Molecular Mimicry:

IMMUNE EVASION:
Protein Modifications

IMMUNE INVASION:
Down-Regulate HLA

BRIDGING THE GAP
B/W Innate and Adaptive Immunity

HLA
HUMAN LEUKOCYTE ANTIGENS

CONCEPT FOR MHC CLASSES

ANTIGEN PRESENTATION TO T CELLS:
MHC CLASS ONE

ANTIGEN PRESENTATION TO T CELLS:
MHC CLASS II

PATHWAYS OF ANTIGEN PROCESSING

Hypervariable Regions
(HLA = responsible for enormous variety of response)

MHC RESTRICTION

Thymic Education:
POSITIVE SELECTION

Thymic Education:
NEGATIVE SELECTION

IMPORTANCE OF HLA IN
BONE MARROW TRANSPLANT

INDIRECT ALLORECOGNITION
(in bone marrow transplantation)

DIRECT ALLORECOGNITION
(in bone marrow transplantation)

HLA MATCHING AND HSC OUTCOME
(stem cell transplant)

CELIAC DISEASE
(pathogenesis)

IMMUNOPATHOGENESIS OF CELIAC DISEASE

Drug Hypersensitivity Reactions:
ABACAVIR

Abacavir hypersensitivity = Multisystem disease

ABACAVIR HYPERSENSITIVITY
(if (+) for HLA-B57:01, need to take another anti-HIV drug instead)

Drug Hypersensitivity Reactions:
ALLOPURINOL

Drug Hypersensitivity Reactions:
CARBAMAZEPINE

NATURAL KILLER (NK) CELLS
(innate)
{MHC Class I}

NK (natural killer) CELL ACTIVATION

ANTIGEN PROCESSING AND PRESENTATION