MICR223 Innate Immunity

Question

What is involved in distinguishing between dangerous and non dangerous pathogens?

Answer 1

Inflammasome

Answer 2

Pathogen association membrane proteins

Answer 3

Protein assisted molecular pathway

Answer 4

Pathogen associated molecular patterns

Answer 5

Pathogen antigen model patterns

Answer 6

Transport proteins around the cell

Answer 7

Produces cytokines directly

Answer 8

Affects gene transcription

Answer 9

Recognises pathogen patterns

Answer 10

Starts a signalling pathway

Answer 11

Flagellin is the PAMP for flagellated bacteria

Answer 12

Lipolysaccharides is the PAMP for Gram -ve bacteria

Answer 13

Peptidoglycan is also a PAMP for Gram -ve bacteria

Answer 14

Zymosan is the PAMP for fungi

Answer 15

ssRNA a PAMP for viral infection

Answer 16

Something heavy in lipids

Answer 17

Something that is fundemental to the cells function

Answer 18

Self antigen.

Answer 19

Something heavy in lipids

Answer 20

Something that is fundemental to the cells function

Answer 21

Self antigen.

Answer 22

Because if we react to self antigen our immune system attacks our own bodies

Answer 23

Because many of the organisms in our body are commensals and killing them could lead to opportunistic infections

Answer 24

Because two signals allow are more controlled reaction

Answer 25

So that if you get one signal and not the other only a small or no response occurs. Minimises damage.

Answer 26

Because if we react to self antigen our immune system attacks our own bodies

Answer 27

Because many of the organisms in our body are commensals and killing them could lead to opportunistic infections

Answer 28

Because two signals allow are more controlled reaction

Answer 29

So that if you get one signal and not the other only a small or no response occurs. Minimises damage.

Answer 30

C-type lectin receptors detect fungal antigen

Answer 31

RIG-1 like Receptors recognise protozoan antigen

Answer 32

Toll like receptors recognise bacterial antigen

Answer 33

NOD- like receptors recognise only bacterial antigen

Answer 34

Dectin-1 Th17 adaptive immune response

Answer 35

Dectin-2 Th17 adaptive immune response

Answer 36

Mannose receptors Th17 adaptive immune response

Answer 37

Bacillius subtilis

Answer 38

Malassezia spp and trehalose dimycolate from M.tuberculosis.

Answer 39

Clostridium spp C.difficile, C.tetani and C.botulinum

Answer 40

Inflammatory cytokines

Answer 41

T cell stimulating cytokines

Answer 42

Anti inflammatory cytokines

Answer 43

RLRs signal outcomes are inflammatory cytokines esp IFNs

Answer 44

CLRs Signal outcomes are Tcell stimulating cytokines esp IL-17

Answer 45

NLRs signal outcomes are Inflammatory cytokines IL-2

Answer 46

In a vesicle

Answer 47

In the cytosol

Answer 48

In the membrane

Answer 49

In the lymph node

Answer 50

NOD1 recognises G -ve bacteria

Answer 51

NOD2 recognises all bacteria

Answer 52

NOD proteins recognise danger and viruses

Answer 53

There is more NOD in epithelial cells

Answer 54

NOD is also in APCs

Answer 55

NOD2 recognises only gram +ve bacteria

Answer 56

NOD1 recognises fungi

Answer 57

Nod proteins recognise danger and protozoa

Answer 58

IL-1, IL-7, IL-17

Answer 59

IL-1, IL-8, IL-18

Answer 60

IL-1, IL-2, IL17

Answer 61

IL-1, TFNbeta, IL-3

Answer 62

To compete for binding of CD28 with CD80.

Answer 63

A link between PRR and transcription.

Answer 64

A mediator of acute inflammation

Answer 65

A anti inflammatory cytokine

Answer 66

A signal from a co-stimulatory receptor that is only expressed when in danger

Answer 67

A signal that indicates cell death e.g. crystal salts.

Answer 68

The inflammasome

Answer 69

Because many auto-immune disease involve excessive inflammation

Answer 70

Because it causes poor immune response

Answer 71

Killed pathogens used in vaccines.

Answer 72

Agents that boost the immune response by acting as danger signals

Answer 73

An auto immune disease?

Answer 74

The build up of uric acid crystals

Answer 75

Excessive inflammation due to signal 2 being activated

Answer 76

IL-1Ralpha used as an antagonist to treat

Answer 77

Inflammatory bowl disease

Answer 78

Addisons disease

Answer 79

Something a Tcells and Bcell receptors recognise

Answer 80

Broken down macromolecules specific to foreign organisms

Answer 81

Something that directly stimulates Tcells to become different subsets

Answer 82

Something that indicates self antigen

Answer 83

Immunogen - antigen that initiates immune system Epitote - part of the antigen that binds to TCR/BCR

Answer 84

Immunogen - part of the antigen that binds to TCR/BCR Epitote - antigen that initiates immune system

Nächster

MICR223 Innate Immunity

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