27207050
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Quiz von Bryan Suringa, aktualisiert more than 1 year ago
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Erstellt von Bryan Suringa
vor mehr als 3 Jahre
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Frage 1
Frage
Which of the following is/are true regarding phase 1 drug metabolism?
Antworten
-
Also known as conjugation reaction
-
Includes only oxidation
-
Generally tends to provide a functional group or “handle” to the molecule
-
NOTA
Frage 2
Frage
Which of the following is/are true regarding phase II drug metabolism?
Antworten
-
Allows the attachment of small, polar and ionizable endogenous compounds
-
Allows the termination or attenuation of a biologic activity
-
serves to protect the body against chemically reactive compounds or metabolites
-
NOTA
Frage 3
Frage
Which of the following undergo an oxidative reaction?
Antworten
-
Olefins
-
alcohols, aldehydes
-
aromatic moieties
-
nitro and azo compounds
Frage 4
Frage
Which of the following is/are examples of drugs that are extensively metabolized by the first pass effect?
Antworten
-
Lidocaine
-
Nitroglycerin
-
Morphine
-
meperidine
Frage 5
Frage
Glucuronidation is the most common conjugative pathway in drug metabolism. Which of the following is/are responsible for this?
Antworten
-
readily available supply of D-glucuronic acid
-
numerous functional groups that can combine enzymatically with glucuronic acid
-
utilization of D-glucuronic acid to conjugate steroids, heparin, chondroitin, catecholamines and thyroxine
-
AOTA
Frage 6
Frage
Which of the following is/are factors affecting drug metabolism?
Antworten
-
Age
-
economic status
-
species and strain
-
gender
Frage 7
Frage
Which of the following is/are true regarding methylation?
Antworten
-
generally leads to polar or water-soluble metabolites
-
important in the biosynthesis of many endogenous compounds like epinephrine and melatonin
-
constitutes only a minor pathway for conjugating drugs or xenobiotics
-
NOTA
Frage 8
Frage
Which of the following is/are considered slow acetylators?
Antworten
-
eskimos
-
egyptians
-
filipinos
-
jews
Frage 9
Frage
Which of the following may induce metabolism of other drugs?
Antworten
-
phenytoin
-
cimetidine
-
meprobamate
-
rifampicin
Frage 10
Frage
The term that denotes the selective metabolism of two or more similar functional groups or two or more similar atoms that are positioned in different regions of a molecule.
Antworten
-
stereoisomerism
-
regioselectivity
-
selective toxicity
-
substrate stereoselectivity
Frage 11
Frage
The process involved in the biotransformation of amitriptyline to nortriptyline.
Antworten
-
N-demethylation
-
Aromatic hydroxylation
-
Epoxidation
-
Ester hydrolysis
Frage 12
Frage
The biotransformation of chloral hydrate via aldehyde reduction forms?
Antworten
-
desipramine
-
mesoridazine
-
trichloroethanol
-
sulindac
Frage 13
Frage
What process is involved in the biotransformation of prednisone to prednisolone?
Antworten
-
ketone reduction
-
O-demethylation
-
sulfoxide reduction
-
Aromatic hydroxylation
Frage 14
Frage
What process is involved in the biotransformation of phenylbutazone to oxybutazone?
Antworten
-
aromatic hydroxylation
-
ketone reduction
-
N-acetylation
-
S-oxidation
Frage 15
Frage
Which of the following is/are metabolites?
Antworten
-
6-mercaptopurine
-
phenylbutazone
-
prednisolone
-
acetaminophen
Frage 16
Frage
Which of the following is/are parent drug/s?
Antworten
-
digitoxin
-
hydrocortisone
-
primidone
-
propranolol
Frage 17
Frage
The property of chemicals to destroy one form of life without harming another.
Antworten
-
stereoisomerism
-
regioselectivity
-
selective toxicity
-
substrate stereoselectivity
Frage 18
Frage
Which of the following may be used to classify chemotherapeutic agents?
Antworten
-
chemical type
-
biologic properties
-
therapeutic indications
-
NOTA
Frage 19
Frage
Which of the following is/are characteristics of an ideal antiseptic?
Antworten
-
rapid and sustained lethal action against microorganisms
-
retain activity in the presence of body fluids
-
high surface tension
-
NOTA
Frage 20
Frage
An agent that prevents infection by the destruction of pathogenic microorganisms when applied to inanimate objects.
Antworten
-
Antiseptic
-
disinfectant
-
antibiotic
-
sanitizer
Frage 21
Frage
Generally accepted other names of alcohol USP
Antworten
-
Ethanol
-
wood alcohol
-
spiritus vini rectificatus
-
wine spirit
Frage 22
Frage
Ethanol that has been rendered unfit for use in intoxicating beverages by the addition of other substances.
Antworten
-
Denatured alcohol
-
wood alcohol
-
isopropyl alcohol
-
formaldehyde
Frage 23
Frage
Phenol coefficient is defined as the ratio of a disinfectant to the dilution of phenol required to kill a given strain of a bacterium. What microorganism is used in determining the phenol coefficient?
Antworten
-
Bacillus subtilis
-
Enterobacter aerogenes
-
Pseudomonas aeruginosa
-
Salmonella typhi
Frage 24
Frage
A 2% solution of iodine in 50% alcohol with sodium iodide.
Antworten
-
Iodine solution
-
iodine tincture
-
lugol’s solution
-
mayer’s reagent
Frage 25
Frage
A preparation of 5% Iodine in water with potassium iodide?
Antworten
-
Iodine solution
-
iodine tincture
-
lugol’s solution
-
mayer’s reagent
Frage 26
Frage
A preparation of 2% iodine in water with sodium iodide?
Antworten
-
Iodine solution
-
iodine tincture
-
lugol’s solution
-
mayer’s reagent
Frage 27
Frage
Povidone-Iodine
Antworten
-
Water-soluble complex that releases iodine slowly
-
provides a non-toxic, non-irritating,non-volatile and non-staining form of iodine
-
used as an antiseptic for skin application before surgery and injection
-
NOTA
Frage 28
Frage
A dye available as vaginal suppositories for the treatment of yeast infections.
Antworten
-
Malachite green
-
methylene blue
-
phenolphthalein
-
gentian violet
Frage 29
Frage
Dye used as an antidote for cyanide poisoning?
Antworten
-
Malachite green
-
methylene blue
-
phenolphthalein
-
gentian violet
Frage 30
Frage
A potent antifungal substance with a polyene structure from Streptomyces nodosus
Antworten
-
Nystatin
-
griseofulvin
-
natamycin
-
amphotericin B
Frage 31
Frage
The aglycone portion of nystatin consisting of a 38-membered ketone ring with a single tetracene and diene chromophores isolated from each other by a methylene group, one carboxyl, one keto, and eight hydroxyl groups.
Antworten
-
Mykinac
-
mycostatin
-
nystatinolide
-
candeptin
Frage 32
Frage
Polyene antibiotic first isolated in 1951 from a strain of Streptomyces noursei by hanzen and brown.
Antworten
-
Nystatin
-
amphotericin b
-
natamycin
-
griseofulvin
Frage 33
Frage
Griseofulvin
Antworten
-
Recommended for the systemic treatment of refractory ringworm infections
-
its bioavailability is notoriously poor
-
it is supplied in “microsize” and “ultramicrosize” forms
-
NOTA
Frage 34
Frage
A series of synthetic antibacterial agents patterned after nalidixic acid, with an effective antibacterial spectrum largely confined to gram-negative bacteria.
Antworten
-
quinolones
-
dihydrotriazines
-
biguanides
-
polyenes
Frage 35
Frage
The structure found among the quinolones which is essential for their antibacterial activity is 1,4-dihydro-4-oxo-3-pyridine carboylic acid.
Antworten
-
True
-
False
Frage 36
Frage
Its congeners represent important alternatives for the treatment of urinary tract infections caused by strains of Proteus resistant to other agents.
Antworten
-
Norfloxacin
-
cinoxacin
-
nitrofurantoin
-
nalidixic acid
Frage 37
Frage
Antibiotic
Antworten
-
A synthetic product produced as a structural analogue of a naturally occurring antibiotic
-
it antagonizes the growth or the survival of one or more species of microorganisms
-
it is effective in low concentration
-
NOTA
Frage 38
Frage
One who led the isolation of streptomycin from Streptomyces griseus:
Antworten
-
Pasteur & Joubert
-
waksman
-
Vuillemin
-
Florey and Chain
Frage 39
Frage
Antibiotic that binds with ribosome 30s subunit
Antworten
-
Chloramphenicol
-
tetracycline
-
erythromycin
-
lincomycins
Frage 40
Frage
Benzylpenicillin binds preferentially to:
Antworten
-
PBP 1a & 1b
-
PBP 2
-
PBP 3
-
PBP 6
Frage 41
Frage
Methicillin is chemically called as:
Antworten
-
2-ethoxy-1-napthylpenicillin
-
5-methyl-3-phenyl-4-isoxazolyl penicillin
-
5-methyl-3-(2,6-dichlorophenyl)-4-isoxazolyl-penicillin
-
2,6-dimethoxyphenyl penicillin
Frage 42
Frage
Amoxicillin
Antworten
-
D-?-Amino-p-hydroxybenzyl-penicillin
-
?-Carboxy-3-thienyl penicillin
-
?-(1-methanesulfonyl-amino) benzylpenicillin
-
D-?-aminobenzyl penicillin
Frage 43
Frage
Structure of the penicillin molecule shows it to contain a fused ring system which is the:
Antworten
-
?-lactam thiazolidine
-
?-lactam penam
-
6-aminopenicillanic acid
-
?-lactam phenyl penicillin ring
Frage 44
Frage
Members of the 4-isoxazolyl penicillin family require these substituents for effectiveness against ?-lactamase producing Staphylococcus aureus.
Antworten
-
3-aryl & 5-methyl group
-
3-acyl & 6-methyl group
-
3-phenyl & 2-methoxy group
-
3-phenyl & 2-methyl group
Frage 45
Frage
These are major antigenic determinants that are formed when penicillins or its rearrangement products in vivo react with lysine-e-amino groups of proteins resulting to allergic reactions.
Antworten
-
Penicillenic acids
-
penicilloyl proteins
-
penicillanic proteins
-
penicillanic acids
Frage 46
Frage
This is prepared by the reaction of ampicillin with acetone
Antworten
-
Unipen
-
hetacillin
-
unasyn
-
methicillin
Frage 47
Frage
Class 1 ?-lactamase inhibitors have hetero atom leaving at position 1. Which of these is/are Class II inhibitors:
I. Carbapenems
II. Sulbactam
III. Clavulanic Acid
Antworten
-
I only
-
I, II
-
II, III
-
III only
Frage 48
Frage
Augmentin is a combination of:
Antworten
-
K salt of Clavulanic Acid
-
amoxicillin
-
ampicillin
-
sulbactam
Frage 49
Frage
Unasyn is a fixed-dose combination of:
Antworten
-
Amoxicillin
-
sulbactam
-
ampicillin
-
clavulanic
Frage 50
Frage
Primaxin is a combination of:
Antworten
-
Tazocillin
-
imipenem
-
piperacillin
-
cilastatin
Frage 51
Frage
Imipenem is the most successful of a series of chemically stable derivatives of thienamycin in which the primary amino group is converted to a non-nucleophilic basic function. Imipenem is also:
Antworten
-
5-acetamido thienamycin
-
5-methyl-3-phenyl-4-isoxazolyl penicillin
-
n-formimidoyl thienamycin
-
?-imidazolyl ethylamine
Frage 52
Frage
D-(4-amino-4-carboxybutyl) is:
Antworten
-
Penicillin N
-
synnematin B
-
cephalosporin N
-
chloramphenicol B
Frage 53
Frage
Cephalosporin C contains:
Antworten
-
Penicillanic acid
-
thiazolidine ring
-
lactone ring
-
dihydrothiazine ring
Frage 54
Frage
A parenteral cephamycin
Antworten
-
Cefoxitin
-
ceftazidime
-
cephalexin
-
cefadroxil
Frage 55
Frage
Zinacef is the first of a series of a-methoxyimino-acyl-substituted cephalosporins that constitute most of the third generation agents. Zinacef is:
Antworten
-
Sterile cefotaxime Sodium, USP
-
Cefuroxime Sodium, USP
-
Moxalactam Disodium, USP
-
Cefepime, USP
Frage 56
Frage
The factors that contribute to an extremely long serum half-life of sterile ceftriaxone disodium, USP
Antworten
-
High fraction of protein binding in the plasma
-
slow urinary excretion
-
it is not metabolized in vivo
-
NOTA
Frage 57
Frage
This increases stability to ?-lactamases while increasing activity against G(-) bacteria at the same time in monobactams:
Antworten
-
4-methyl group
-
3-methoxy group
-
oximinoacyl group
-
2-aryl group
Frage 58
Frage
The 1st aminoglycoside antibiotic to be used in chemotherapy:
Antworten
-
Amikacin
-
gentamicin
-
streptomycin
-
kanamycin
Frage 59
Frage
MOA of Aminoglycosides:
Antworten
-
Interferes with cell wall synthesis
-
act directly on the bacterial ribosome to inhibit the initiation of protein synthesis
-
interferes with the fidelity of translation of the genetic message
-
NOTA
Frage 60
Frage
Extrachromosomals which are self-replicative and transferable by conjugation that is responsible for the transfer of resistance from one bacterium to another.
Antworten
-
R-factor
-
F-factor
-
S-factor
-
X-factor
Frage 61
Frage
SAR of Aminoglycosides: important for characteristic broad-spectrum antibacterial activity & is the primary target for bacterial inactivating enzymes.
Antworten
-
Ring I
-
Ring II
-
Ring III
-
Ring IV
Frage 62
Frage
Known as Streptomycin B
Antworten
-
Streptomycin
-
Mannisidostreptomycin
-
Hydroxystreptomycin
-
Paromomycin Sulfate, USP
Frage 63
Frage
Acid hydrolysis of Streptomycin yields:
Antworten
-
Streptidine
-
Streptobiosamine
-
Deoxystreptamine
-
NOTA
Frage 64
Frage
Neomycin is obtained from:
Antworten
-
S. fradiae
-
S. rimosus
-
S. kanamyceticus
-
Micromonospora purpurea
Frage 65
Frage
The synthesis of this semisynthetic aminoglycoside involves simple acylation of the 1-amino group of the deoxystreptamine ring of Kanamycin A with L-amino-a-hydroxybutyric acid (L-AHBA)
Antworten
-
Tobramycin
-
Netilmicin
-
Amikacin
-
Gentamicin
Frage 66
Frage
A group of antibiotics that are derivatives of an octahydronaphthalene, a hydrocarbon system that comprises four annelated six-membered rings.
Antworten
-
Macrolides
-
tetracycline
-
lincomycins
-
sulfonamides
Frage 67
Frage
7-Chloro-6-demethyl tetracycline is:
Antworten
-
demeclocycline
-
Oxytetracycline
-
minocycline
-
Doxycycline
Frage 68
Frage
Macrolide antibiotics have these common characteristics:
Antworten
-
Large lactone ring
-
ketone group
-
a glycosidically linked amino sugar
-
an asymmetric carbon atoms in the acylamidopropanediol chain
Frage 69
Frage
Bacillus subtilis strain that was isolated from debrided tissue of a compound fracture in 7-year old Margaret Tracy produced this antibiotic.
Antworten
-
Gramicidin
-
Bacitracin
-
Colistin
-
Polymyxin
Frage 70
Frage
The first of the widely used broad-spectrum antibiotic that was isolated by Ehrlich in 1947 from S. venezuelae
Antworten
-
Clindamycin
-
Chloramphenicol
-
Vancomycin
-
Novobiocin
Frage 71
Frage
Erythromycin B differs from Erythromycin A only at carbon 12, at which hydroxyl group is replaced by ______, which renders it more acid stable.
Antworten
-
Bromine
-
Chlorine
-
Hydrogen
-
Oxygen
Frage 72
Frage
These are sulfur-containing antibiotics isolated from S. lincolnensis
Antworten
-
Bacitracin
-
novobiocin
-
lincomycins
-
vancomycins
Frage 73
Frage
7-Chloro-7-deoxy lincomycin
Antworten
-
Cleocin
-
Unasyn
-
Unipen
-
Lincocin
Frage 74
Frage
Bacitracin’s bactericidal effect through an inhibition of mucopeptide cell wall synthesis is enhanced by:
Antworten
-
P
-
Zn
-
Cl
-
S
Frage 75
Frage
Analogue of podophyllotoxin that is an inhibitor of Topoisomerase II which contains methyl as its R group:
Antworten
-
Vindoline
-
Etoposide
-
Vincristine
-
Epipodophyllotoxin
Frage 76
Frage
The complex structures in vinca alkaloid composed of indole-containing moiety and an indoline-containing moiety:
Antworten
-
Indoline
-
Vindoline
-
Vindesine
-
Catharanthine
Frage 77
Frage
Is an antineoplastic agent preparation from E. coli containing the enzyme L-asparagine amidohydrolase
Antworten
-
Asparaginase
-
Elspar
-
Pipobroman
-
Platinol
Frage 78
Frage
An antineoplastic drug active against rapidly proliferating cells in the synthesis phase during which it prevents the formation of deoxyribonucleotides by inhibition of ribonucleotide diphosphate reductase.
Antworten
-
Carboplatin
-
hydroxyurea
-
mitoguazone
-
hycanthone
Frage 79
Frage
Used primarily for polycythemia vera:
Antworten
-
Hexamethylamine
-
asparaginase
-
tamoxifen
-
pipobroman
Frage 80
Frage
D-Homo-17a-oxa androsta-1,4-dione prepared by microbial transformation of progesterone
Antworten
-
Tamoxifen
-
testolactone
-
megestrol
-
ethinyl estradiol
Frage 81
Frage
Interferons are secreted by cells in response to viral infections or other chemical or biologic inducers. The major classes of interferons are:
Antworten
-
alpha
-
Beta
-
Lambda
-
Gamma
Frage 82
Frage
It is a highly purified protein containing 165 amino acids manufactured from a strain of E.coli bearing a genetically engineered plasmid containing an interferon alfa-2a gene from human leukocytes.
Antworten
-
RIFN
-
IFLrA
-
Roferon-A
-
Interon
Frage 83
Frage
This is absolutely essential for the in-vitro carbonic anhydrase inhibitory activity and for the production of a diuresis in vivo.
Antworten
-
Sulfamoyl group
-
neptazane
-
amino group
-
Imino group
Frage 84
Frage
Diamox
Antworten
-
Acetazolamide
-
Hydrochlorothiazide
-
Amoxicillin
-
Dichlorphenamide
Frage 85
Frage
Benzothiazine-1,1-dioxide nucleus is contained in:
Antworten
-
Carbonic anhydrase inhibitors
-
thiazide diuretics
-
loop diuretics
-
phenoxyacetic acids
Frage 86
Frage
4-Chloro-N-furfuryl-5-sulfamoyl anthranilic acid is:
Antworten
-
Bumetanide
-
furosemide
-
ethacrynic acid
-
chlorothiazide
Frage 87
Frage
Primary compound selected from a host of pteridine analogues and resembles the structure of folic acid and certain dihydrofolate reductase inhibitors.
Antworten
-
Spironolactone
-
amiloride
-
theophylline
-
triamterene
Frage 88
Frage
A pyrazinoyl guanidine diuretic that inhibits the electrogenic entry of 2% to 3% of the filtered load of Na into the tubule cells.
Antworten
-
Triamterene
-
spironolactone
-
amiloride
-
aldosterone
Frage 89
Frage
The major adverse effect of midamor:
Antworten
-
hypomagnesemia
-
hyponatremia
-
hypocalcemia
-
hyperkalemia
Frage 90
Frage
?-imidazolylethylamine, an autacoid, is widespread in nature being found in ergot and other plants and in all organs and tissues of the human body. It’s also known as:
Antworten
-
1H-imidazole-4-ethenamine
-
histamine
-
serotonin
-
NOTA
Frage 91
Frage
The major source of histamine in the body results from the decarboxylation of this amino acid:
Antworten
-
Tryptophan
-
Histidine
-
Tyrosine
-
Phenylalanine
Frage 92
Frage
Drowsiness is a side effect of antihistamines that is most common to the:
Antworten
-
Ethylenediamines
-
tertiary aminoalkyl ethers
-
phenothiazines
-
cimetidine
Frage 93
Frage
A propylamine derivative:
Antworten
-
Diphenhydramine
-
Clemastine
-
Carbinoxamine
-
Brompheniramine
Frage 94
Frage
Dramamine
Antworten
-
Doxylamine
-
Dimenhydrinate
-
Diphenhydramine
-
Cyclizine
Frage 95
Frage
The piperazine, imidazoline and phenothiazine type antihistamines contain the following moiety:
Antworten
-
Aminoalkyl ethers
-
ethylene diamine
-
propylamine
-
butyrophenone
Frage 96
Frage
Antihistamine resulting from the chlorination of pheniramine in the para position of the phenyl ring that gives a tenfold increase in potency with no appreciable changes in toxicity.
Antworten
-
Brompheniramine
-
chlorpheniramine
-
pyrrobutamine
-
promethazine
Frage 97
Frage
A sulfone derivative investigated initially to be the most effective drug for the treatment of leprosy and has useful antimalarial property but was too toxic.
Antworten
-
4,4’-diamidodiphenylsulfide
-
4,4’-diaminodiphenylsulfone
-
3,4’-diaminediphenylsulfide
-
3,4’-diamidodiphenylsulfone
Frage 98
Frage
What antibiotic caused a major advance in the treatment of tuberculosis?
Antworten
-
Isoniazid
-
ethionamide
-
rifampin
-
cycloserine
Frage 99
Frage
Ethambutol is remarkably stereospecific. Toxicities of its isomers are about equal but their activity varies considerably. Factors that have pronounced effect on the activity are:
Antworten
-
Length of the alkylene chain
-
nature of the branching with the alkyl substituents in the nitrogens
-
extent of N-alkylation
-
pyranolone ring at the C4 of the compound
Frage 100
Frage
Ethionamide is a second-line treatment drug for tuberculosis and used in the treatment of INH-resistant tuberculosis or when the patient is intolerant to INH and other drugs. What is its structural difference with the INH series?
Antworten
-
5 - substitution
-
2 - substitution
-
addition of a thiazolidine ring
-
addition of a pyranolone ring
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