MICR223 Flashcards on Immune response, created by ruby.white94 on 10/13/2013.
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Created by ruby.white94
over 10 years ago
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PRRs
PAMPs
Transcription factors turned on by MyD88 dependant and independant signalling
C-type Lectin receptors
Mincle
RIG-1 like receptors
Th1 Tcell
what activates it
what response does it produce
Th2 CD4 Tcells
What does MyD88 independant signalling use instead of MyD88?
Explain the structure of a BCR
Explain the structure of a TCR
What are two other sources of variation for the Bcell receptor other than rearrangment?
RSS
RAG-1 and RAG-2
How is RAG-1 and RAG-2 cutting repaired?
Allelic exclusion
Where does Negative and positive selection of Tcells occur
Negative selection
Positive selection
Features of cytokines
Pleiotrophic
Why are cytokines tightly regulated and how?
What does sustained of systemic production of cytokines lead to?
IL-2, IL-6, TNFalpha
Endogenous pyrogens
What are effects of pro-infammatory cytokines
Cytokine storm
Anti-inflammatory cytokines
IL-10 effects
Chemokines
Describe overall chemokine structure
CXC chemokines
CC chemokines
C chemokines
CX3C chemokines
Structure of a chemokine receptor?
IL-8
Antigen specific
Coreceptor
Adhesion
Co-stimulation
What inflammatory signals does the APC give the Tcell?
CTLA-4
p-SMAC
Describe the intracellular process of TCR activation
Outcome of TCR activation
Th
Tc
What do CD4 Tcell subsets do?
What do CD8 Tcell subsets do?
CD4 Th1
CD4 Th2
What can result from Th1 and Th2 if things go wrong?
IL-12
IL-23
Th17 immune cells
Tfh
Th9
Type 1 response CD8
Type 2 responses CD8
Non conventional Tcells
Non convential Tcell NK
What two types of transcription factors are needed in Tcell activation?
Th1
Th2 cells
Th17 cells
What are the five ways of keeping a tcell subset that subset?
What controls the speed of response?
What controls the magnitude of a response?
What drives the resolution of a response
Tregs
Natural Tregs
Induced Tregs
What do Tregs express?
Foxp3
Foxp3
Foxp3
Foxp3
IL-10 secretion by Tregs
TGFb expression by Tregs
CTLA-4 and Tregs
IPEX
M2
What do B cells do?
Tcell dependant antibody production
CD40L
CD40L
Spleen
White pulp
Germinal centres
Role of antibodies
Somatic hypermutation
AID
Affinity maturation
Where does somatic hypermutation and antibody class switching occur
Antibody classes
What three forms does antibody come in?
IgM
IgG
IgD
IgA
IgE
What drives class switching?
What is initally produced in an immune response followed by what?
What isotype do naive b cells express?
What is immunological memory?
Immunology memory is
Where do short lived plasma cells reside
Long lived plasma cells reside in?
What are long lived plasma cells a source
Where do memory Bcells arise from?
Features of a memory Bcell
T memory cells
Features of T memory cells
Why are T memory cell better?
Central memory
Effector memory
