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Which of the following is an injectable Factor Xa inhibitor?
dabigatran
warfarin
rivaroxaban
fondaparinux
True or False
Fondaparinux is obtained from animal sources
True or False
Fondaparinux contains the specific five saccharide sequence that is found in UFH
Fondaparinux is not metabolised in the liver and is renally eliminated
True or False:
The anticoagulant effect of fondaparinux can be reversed by protamine
which of the following is oral factor Xa inhibitor?
enoxaparin
lepirudin
rivaroxaban
True or False:
rivaroxaban has relative bioavailability of 80% and is 2/3 eliminated renally
which of the following is not a direct thrombin inhibitors?
enoxaparin
warfarin
hirudin
bivalirudin
lepirudin
where did hirudin first come from?
what is hirudin composed of?
how is lepirudin made?
How does bivalirudin differ from lepirudin?
what is an example of an oral direct thrombin inhibitor?
True or False:
Dabigatran is a univalent DTI (binds only to one site) while bivalirudin and hirudin bind to two sites on thrombin
Explain why dabigatran is administered as dabigatran etexilate
what is the dominant pathway for eliminaiton of dabigatran?
Explain the design of Pradaxa capsules
why should pellets not be removed from pradaxa capsules and administered this way?
what are advantages of dabigatran orally compared to warfarin orally
what are some disadvantages of dabigatran compared to warfarin
