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HIV

HIV

Question 1 of 4

1

Regarding HIV infection all of the following are true except

Select one of the following:

  • It is retrovirus that infects CD4 T cells, dendritic cells and macrophages and binds to gp120

  • gp 120 changes conformation and binds co-receptors CCR5 and CXCR4

  • Reverse transcriptase copies viral ssRNA genomes into ds cDNA

  • Replication of HIV occurs in activated T and B cells

  • A genetic deficiency of the co-receptor CCR5 confers resistance to HIV infection in vivo

Explanation

Question 2 of 4

1

All of the following are seen in a typical course of HIV infection except

Select one of the following:

  • Infected CD4 cells die as a result of viral replication

  • There is a latent viral reservoir in the lymphoid tissue

  • gp 120 expressed on infected cell binds CD4 on uninfected cell and they fuse forming multinucleated giant cells in HIV infected brain

  • Opportunistic infections will begin to arise when CD4 T cell count goes below 400 cell/cubic mm

Explanation

Question 3 of 4

1

You need 2 positive ELISA and a confirmatory positive Western Blot to confirm HIV positive status

Select one of the following:

  • True
  • False

Explanation

Question 4 of 4

1

All of the following are true about HIV drugs except?

Select one of the following:

  • Block CCR5 - will block fusion

  • Block Reverse Transcriptase - Blocks integration

  • Block maturation (gp 160 -> gp41)

  • HAART (Highly Active Anti-retroviral Therapy) = 1 NRTIs + a PI/NNRTI/II

Explanation

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