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Pharmacology - Bio 528

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Local Anesthetics - quiz

Local Anesthetics - quiz

Question 1 of 13

1

A weak acid becomes more than 50% un-ionized following IV injection (blood pH = 7.4). The pKa of this weak acid could be...

Select one of the following:

  • 7.6

  • 7.4

  • 7.2

  • 1.5

Explanation

Question 2 of 13

1

When injected into the body, any of the local anesthetics used currently in clinical practice will be:

Select one of the following:

  • less than 50% un-ionized

  • more than 50% un-ionized

  • 50% un-ionized

  • 100% un-ionized

Explanation

Question 3 of 13

1

Sodium drug has pKa of 8.2. When injected into the blood, this drug will become:

Select one of the following:

  • less than 50% un-ionized

  • more than 50% un-ionized

  • 50% un-ionized

  • 100% un-ionized

Explanation

Question 4 of 13

1

What situation most facilitates accumulation of local anesthetic by the fetus?

Select one of the following:

  • maternal acidosis and fetal acidosis

  • maternal acidosis and fetal alkalosis

  • maternal alkalosis and fetal alkalosis

  • maternal alkalosis and fetal acidosis

Explanation

Question 5 of 13

1

Potency is determined by what property(ies) of a local anesthetic?

Select one of the following:

  • pKa

  • lipid solubility

  • protein binding

  • both lipid solubility and protein binding

Explanation

Question 6 of 13

1

Speed of onset is determined by what property(ies) of a local anesthetic?

Select one of the following:

  • pKa

  • lipid solubility

  • protein binding

  • both lipid solubility and protein binding

Explanation

Question 7 of 13

1

Duration of action is determined by what property(ies) of a local anesthetic?

Select one of the following:

  • pKa

  • lipid solubility

  • protein binding

  • both lipid solubility and protein binding

Explanation

Question 8 of 13

1

Local anesthetics work on which segment(s) of the neuron?

Select one of the following:

  • axon only

  • cell body and axon

  • axon and nerve terminal

  • cell body, axon and nerve terminal

Explanation

Question 9 of 13

1

Conduction block occurs when the...

Select one of the following:

  • ionized form of the local anesthetic binds to the voltage-gated sodium channel outside the cell

  • ionized form of the local anesthetic binds to the voltage-gated sodium channel inside the cell

  • un-ionized form of the local anesthetic binds to the voltage-gated sodium channel outside the cell

  • un-ionized form of the local anesthetic binds to the voltage-gated sodium channel inside the cell

Explanation

Question 10 of 13

1

You can make your own local anesthetic. If you want the local anesthetic to have a fast onset, you will want to have the local anesthetic have what pKa?

Select one of the following:

  • 2.3

  • 7.0

  • 7.4

  • 11.5

Explanation

Question 11 of 13

1

Injection of local anesthetic at which of the following sites is most likely to result in systemic toxicity?

Select one of the following:

  • epidural space

  • paracervical tissue

  • intercostal muscles

  • brachial plexus

Explanation

Question 12 of 13

1

Methemoglobinemia can occur if what local anesthetic is used?

Select one of the following:

  • Tetracaine

  • Prilocaine

  • Ropivacaine

  • Mepivacaine

Explanation

Question 13 of 13

1

What condition most prevents passage of local anesthetic from fetus to mom?

Select one of the following:

  • maternal alkalosis

  • maternal acidosis

  • fetal alkalosis

  • fetal acidosis

Explanation

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