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undergrad Microbiology Quiz on Viruses, created by marthas2705 on 12/20/2015.

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  • Viruses

    Question 1 of 12

    1

    A virus is a acid surrounded by a protein coat (). Replication is dependent on a host cell, viruses can't replicate on their own so are .
    CYCLE- they are introduced in the popn, they , they cell defences. Some do this by: quickly to escape being recognised by the immune system, some have safe ways to escape, some aren't good at escape but can replicate and infect so the immune system has to respond to them.
    They cause disease and attract publicity. HIV is one of the biggest killers, but not always lethal.

    TYPES of virus:
    ds DNA, ssDNA, dsRNA, ssRNA and retrovirus ( virus with intermediate)

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      protective
      protective
      nucleic
      nucleic
      capsid
      capsid
      obligate parasites
      obligate parasites
      spread
      spread
      escape
      escape
      very easily
      very easily
      changing
      changing
      no time
      no time
      RNA
      RNA
      DNA
      DNA

    Question 2 of 12

    1

    Fill the blank spaces to complete the text.

    Viruses have and extracellular () phases. Virions are much smaller than other life forms.
    VIRIONS
    Nucleic acid surrounded by protective protein . The capsid is a distinctive feature. It's very repetitive. Some virions are surrounded by a membrane= virus, with no membrane=

    The capsid is made of . = nucleic acid+capsid.
    Attachment to target cells is mediated by or spikes on viral surface which bind to host surface molecules. often . these are viral receptors.

    Question 3 of 12

    1

    Fill the blank spaces to complete the text.

    CELL ENTRY
    1) FUSION. of virion attach to host cell (adsorption), the envelope of the virion then fuses with the plasma membrane. This releases the into the cytoplasm, the viral envelope part of the plasma membrane. The nucleic acid then from the coat protein.

    2) . Virion adsorbs to hot cell, endocytosis. Plasma membrane surrounds the vision and a forms. This also occurs for viruses.

    Question 4 of 12

    1

    DNA viruses MUST GO to as they need transcription-->Viral DNA is transported to the nucleus-->Host converts DNA to viral in the nucleus this then is transported to -->Viral RNAs are translated to new viral proteins and transported back to the -->Viral DNA gets replicated by --> reassembly of viral genome and proteins followed by

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      the NUCLEUS
      the NUCLEUS
      host
      host
      RNA polymerase
      RNA polymerase
      mRNA
      mRNA
      the cytoplasm
      the cytoplasm
      nucleus
      nucleus
      DNA poly
      DNA poly
      release
      release

    Question 5 of 12

    1

    ssRNA viruses:
    Viral RNA translated to proteins by . Viral is replicated by . Viral proteins form the and encapsulate replicated RNA genomes to form new . New virions then bud from the infected cell.

    Viral proteins which are to become attach to the plasma membrane. Viral protein coats the inside of the membrane. Nucleocapsids become enclosed by viral envelope composed of host plasma membrane. =

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      cytoplasmic ribosomes
      cytoplasmic ribosomes
      viral synthetase
      viral synthetase
      RNA genome
      RNA genome
      capsid
      capsid
      virions
      virions
      spikes
      spikes
      matrix
      matrix
      BUDDING
      BUDDING

    Question 6 of 12

    1

    Select from the dropdown lists to complete the text.

    Viral infections can cause: tumour, cell lysis, persistent infection or latent infection
    SMALLPOX:
    ds DNA virus, starts as ( respiratory, gastrointestinal, skin, ear ) infection with a high mortality but lead to high immunity. Edward Jenner created vaccination with cowpox but this later changed to vaccinia virus. It was eradicated because it was: ( exclusive to humans, only exhibited in humans and cows, not exclusive to humans ), ( no hidden, obvious, only a few ) carriers, 100% vaccine success, only ( 1 serotype, visible serotypes ).

    Question 7 of 12

    1

    Fill the blank spaces to complete the text.

    Viruses can change. They infect, immunity ensues, then they change and evolve. There are types of herpesvirus, alpha beta and gamma, and they are sDNA viruses with large genomes. Infections are lifelong. They undergo a cycle where few viral proteins are expressed and no virions are produced. They can be activated to express a cycle where all viral proteins are expressed and virions are produced to infect new cells.

    Herpes simplex. . Infects and manifests as cold sores. If they aren't present then the virus is latent and reactivates due to .
    Enveloped virus.

    Poliovirus is a +ve strand ss virus with a linear genome. structure. Virion has 4 proteins. vpg protein at 5' end and polyA tail at 3' end.
    RNA acts as mRNA and is translated by ribosomes. A large is cleaved to produced 20 proteins. RNA transcribes viral RNA to negative RNA strand. This acts as a template for a new +ve RNA strand.

    Question 8 of 12

    1

    Poliomyelitis- infection, infects before . Targets nerve cells and destroys them, causing of infected tissues. It develops very quickly so there are no long term asymptomatic carriers, No reservoir in nature.

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      oral
      oral
      gut
      gut
      blood
      blood
      paralysis
      paralysis
      non primate
      non primate

    Question 9 of 12

    1

    Fill the blank spaces to complete the text.

    POLIOMYELITIS. - treated with formaldehyde, prevents entry to nerve cells but gut infection remains.
    ADV
    effective, can be incorporated into vaccines, good in transport and storage, no risk of poliomyelitis in recipients and contacts.
    DIS
    Doesn't introduce local gut immunity, vaccines are needed admin by , higher community vaccination levels needed

    : cell culture, introduces immunity in the gut and prevents infection
    ADV
    Effective, , similar imm response to natural infection, community immunisation by spread of attenuated virus, oral, no booster needed.
    DIS
    Induced poliomyelitis, spread without and unsafe for immunocompromised ppl

    Question 10 of 12

    1

    Influenza A B and C. -ve virus. Killed 20-40 mil in 1918. genome with 8 segments to produce . Helical nucleoprotein. No defined shape, enveloped. (HA) attaches to host receptors. (NA) breaks down sialic acid to allow budding.
    1) taken up by
    2)RNA -ve strand converted to mRNA by viral RNA polymerase.
    3)mRNA translated in cytoplasm to make proteins.

    Antigenic drift- mutation. Occurs as a result of activity of viral .
    Antigenic - reassortment and strong change, viruses infective different can recombine in a permissive host leading to major genomic changes.

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      ssRNA
      ssRNA
      8 proteins
      8 proteins
      Segmented
      Segmented
      Hemagglutinin
      Hemagglutinin
      Neuraminidase
      Neuraminidase
      endocytosis
      endocytosis
      viral
      viral
      minor
      minor
      polymerase
      polymerase
      shift
      shift
      major
      major
      species
      species

    Question 11 of 12

    1

    Flu vaccine

    Select one or more of the following:

    • made of killed vaccine of 3 strains

    • made of live vaccine

    • given to most vulnerable

    • given to everyone

    • recombinant HA vaccine

    Question 12 of 12

    1

    Fill the blank spaces to complete the text.

    Flu drugs
    Target protein to stop viral in the cell e.g. amantidine. Target to stop viral budding e.g. tamiflu.

    Many flu viruses in birds and pigs. Can spread to other animals. Usually not human to human. Serious concerns that antigenic drift or shift would result in human to human transmission.

    Avian influenza infects deep alveolar cells in lungs, causes a strong response called a where a person's own organs are attacked.