Pulmonology - TB Pharmacology

Anti - TB Agents
First Line

Anti _TB Agents
Second Line

Isoniazid (INH)

INH
Mechanism of Action

INH
Half Life
Dose
Metabolism
Bioavailability

INH
Toxicity

Rifampin
Mechanism of Action

Rifampin
Half life
Dose
Metabolism
Bioavailability

Rifampin
Toxicity

Pyrazinamide (PZA)
Mechanism of Action

PZA
Half Life
Dose
Excretion
Bioavailability

PZA
Toxicity

Ethambutol

Ethambutol
Mechanism of Action

Ethambutol
Half Life
Dose
Metabolism
Bioavailability

Ethambutol
Toxicity

Anti - TB Chemotherapy
Primary Goals

Anti - TB Chemotherapy
Rationale for combination therapy

Duration of TB Therapy
Pulmonary TB

Duration of TB Therapy
Extra pulmonary TB

INH
Resistance

Rifampin
Resistance

Preventing Multidrug Rresistant - TB

Cross Drug Resistance - TB

DOT (Directly observed therapy)
Optimizing adherence

TB Discharge Planning
Connecticut State Law

Alternative TB Agents
Rifabutin

Alternative TB Agents
Rifabutin
Toxicity

Alternative TB Agents
Quinolones

Alternative TB Agents
Quinolones
Moxifloxacin

Alternative TB Agents
Aminoglycosides
Streptomycin

Alternative TB Agents
Aminoglycosides
Streptomycin
Dosing

Alternative TB Agents
Aminoglycosides
Streptomycin
Toxicity

Alternative TB Agents
Cycloserine

Alternative TB Agents
Cycloserine
Toxicity

Alternative TB Agents
Ethionamide

Alternative TB Agents
Ethionamide
Toxicity

Alternative TB Agents
P-Aminosalicylic acid (PAS)

Alternative TB Agents
P-Aminosalicyclic acid (PAS)
Toxicity

Other TB Medications
Amikacin
Capreomycin

Other TB Medications
Linezolid

Other TB Medications
Bedaquiline

Other TB Medications
Bedaquiline
Risk

CNS Penetration of Anti - TB Agents