Structural Basis for Biological Function (Molecular Motors) Flashcards on Motor Proteins- Kinesin, created by gina_evans0312 on 12/15/2013.
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Created by gina_evans0312
over 10 years ago
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Created by gina_evans0312
over 10 years ago
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Reason for Cellular Transporters
Role of Transport Proteins
Giant Squid Axon
Anteriograde transport
Retrograde transport
ATP
Protein that makes up microtubules
Distance between each motor protein binding site
Size of microtubules
+ve end of microtubule
-ve end of microtubule
Microtubule ATP requirement
No of Kinesin types in cell
Kinesin Superfamily
Direction of Kinesin movement
Structure of Kinesin 1- Chains
Design of Kinesin 1 - Cargo binding
Design of Kinesin 1 - Stalk
Design of Kinesin 1 - Microtubule binding sites
Design of Kinesin 1 - Neck Linkers
Role of Neck linker
Role of coiled coil stalk
Sliding assay
Rate of Kinesin movement
Processive movement
Monomeric heavy chain kinesin mutants
Potential Models for movement of Kinesin
Optical Trap
Inchworm Model
Hand Over Hand model
Determining Kinesin Movement Method
Precision of Fluorophore Method
Role of Switch's I & II
Movement of Switch II
ATP Binds to sensor
ATP binding & sensor relationship
Relay Helix
Conformational changes of ATP binding
12 amino acid loop
