Michael Jardine
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PHSI3012 (PHSI3012 Topic 1 - Cancer) Quiz on PHSI3012 04-2 Leukaemia, created by Michael Jardine on 26/08/2017.

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Michael Jardine
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PHSI3012 04-2 Leukaemia

Question 1 of 20

1

The vast majority of cancers are:

Select one of the following:

  • Monoclonal

  • Polyclonal

Explanation

Question 2 of 20

1

Etymology.
The "Leuk-" part of leukaemia means what?

Select one of the following:

  • Blood

  • White

  • Cancer

Explanation

Question 3 of 20

1

Etymology.
The "-aemia" part of leukaemia means what?

Select one of the following:

  • Blood

  • White

  • Cancer

Explanation

Question 4 of 20

1

Most cancers are derived from what type of cells?

Select one of the following:

  • Epithelial

  • Mesenchymal

Explanation

Question 5 of 20

1

Blood cell malignancies.
The most obvious difference between Leukaemia and Lymphoma is what?

Select one of the following:

  • Leukaemia is mainly in circulation.
    Lymphoma is mainly in lymph nodes (or spleen).

  • Leukaemia is mainly in lymph nodes (or spleen).
    Lymphoma is mainly in circulation.

  • No noticeable differences.

Explanation

Question 6 of 20

1

Roughly what proportion of the cells in your body are blood cells?

Select one of the following:

  • 1 / 2

  • 1 / 4

  • 1 / 8

  • 1 / 16

  • 1 / 32

  • 1 / 64

Explanation

Question 7 of 20

1

What is the etymology of Macrophages?
(which are a subcategory of Leukocytes)

Select one of the following:

  • Macro- = "Big"
    -phage = "Eater"

  • Macro- = "Little"
    -phage = "Eater"

  • Macro- = "Big"
    -phage = "Enzyme"

  • Macro- = "Little"
    -phage = "Enzyme"

Explanation

Question 8 of 20

1

Etymology.
Blast cells. What does "Blast" mean in Greek?

Select one of the following:

  • Bud

  • Destroyer

  • Eater

  • Builder

Explanation

Question 9 of 20

4

What are the distinguishing features of Blast Cells?
(select all that apply)

Select one or more of the following:

  • Haematopoietic progenitor cells

  • Highly proliferative

  • Large, transcriptionally active nucleus

  • Survival and proliferation dependent on Growth Factor signalling

  • Hepatopoietic progenitor cells

  • Fully mature cells

  • Normally found in large quantities in blood vessels

Explanation

Question 10 of 20

1

True or false?
Mature blood cells typically have more active nuclei than blasts.

Select one of the following:

  • True
  • False

Explanation

Question 11 of 20

1

True or false?
-blasts are the most likely cell type to become Leukaemic.

Select one of the following:

  • True
  • False

Explanation

Question 12 of 20

1

True or false?
-blasts are the least likely cell type to become Leukaemic.

Select one of the following:

  • True
  • False

Explanation

Question 13 of 20

1

True or false?
Mature blood cells typically have less active nuclei than blasts.

Select one of the following:

  • True
  • False

Explanation

Question 14 of 20

4

There are 4 types of Leukaemia. These include:
(select all that apply)

Select one or more of the following:

  • ALL - Acute Lymphoblastic Leukaemia

  • AML - Acute Myelogenous Leukaemia

  • CLL - Chronic Lymphoblastic Leukaemia

  • CML - Chronic Myelogenous Leukaemia

  • ALL - Acute Lymphatic Leukaemia

  • AML - Acute Myelodysplastic Leukaemia

  • CLL - Chronic Lymphatic Leukaemia

  • CML - Chronic Myelodysplastic Leukaemia

Explanation

Question 15 of 20

2

Select from the dropdown lists to complete the text.

Acute Leukaemias arise from ( Stem Cells, Committed Precursors, Late Precursors and Mature Forms ) .
Chronic Leukaemias arise from ( Stem Cells, Committed Precursors, Late Precursors and Mature Forms ) .

Explanation

Question 16 of 20

1

Select from the dropdown list to complete the text.

There are 3 ways to donate marrow.
1 - Bone marrow transplant (becoming less common, though)
2 - PBSC
3 - Cord Blood (saved since birth)

PBSC stands for ( Purified, Peripheral, Progenitor, Please don't fuck this up ) Blood Stem Cell

Explanation

Question 17 of 20

1

The Philadelphia chromosome (AKA Bcr-Abl) is a translocation between chromosomes 9 and 22 that results in a fusion protein called "BCR-ABL". What is the effect of this?

Select one of the following:

  • Blocks myeloid differentiation in the progenitor stage

  • Blocks myeloid differentiation in the haematopoietic stem cell stage

  • Blocks lymphoid differentiation in the progenitor stage

  • Blocks lymphoid differentiation in the haematopoietic stem cell stage

Explanation

Question 18 of 20

1

Bcr-Abl.
Bcr = Breakpoint Cluster Region protein
Abl = Abelson Murine Leukaemia viral oncogene homolog 1 (a non-receptor tyrosine kinase)
The fusion of the two results in what?

Select one of the following:

  • Constitutive activation of the Abl kinase

  • Inactivation of the Abl kinase

Explanation

Question 19 of 20

1

Lymphoma is a malignancy arising from which of the following?

Select one of the following:

  • Progenitor B and T cells in the peripheral lymphoid tissues

  • Progenitor B and T cells in the bloodstream

  • Erythrocytes in the bloodstream

  • Leukocytes in the bloodstream

Explanation

Question 20 of 20

4

Which of the following are symptoms of Leukaemia?
(select all that apply)

Select one or more of the following:

  • Hyperviscosity syndrome

  • Bruising

  • Anaemia

  • Arthritis

  • Splenomegaly

  • Abnormal blood cell profiles (more nucleated cells in the blood)

  • Abnormal blood cell profiles (fewer nucleated cells in the blood

Explanation

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