The major cytochrome P450 isozymes and their common substrates, polymorphisms, inducers, and inhibitors
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Created by Breanna Felldin
over 6 years ago
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Close
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Created by Breanna Felldin
over 6 years ago
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What are the seven major cytochrome p450 (CYP) enzymes that are important to know?
What is a prodrug?
What is induction?
What is inhibition?
What is a polymorphism, with regards to CYP enzymes?
For which of the major CYP enzymes do known polymorphisms exist?
Which major CYP enzyme comprises 40-55% of hepatic CYPs?
Which major CYP enzyme comprises only 2% of hepatic CYPs?
Which major CYP enzyme contributes most to the enterocyte CYPs?
Where is 1A4 found, aside from the liver?
Where is 2C9 found, aside from the liver?
Where is 2C19 found, aside from the liver?
Where is 2D6 found, aside from the liver?
Where is 2E1 found, aside from the liver?
Where is 3A4 found, aside from the liver?
Order the major CYP enzymes from least to greatest metabolizers of typical drugs
Polymorphisms of which two CYP enzymes are likely to be poor metabolizers?
Polymorphisms of which CYP enzyme is likely to be an ultra extensive metabolizer?
Which population is most likely to have a poor metabolizing polymorphism for 2C19? Compare this population to others in terms of percentages.
Which population is most likely to have a poor metabolizing polymorphism for 2D6? Compare this population to others in terms of percentages.
Which two populations are most likely to have an ultra extensive metabolizing polymorphism for 2D6?
What are two common substrates for 1A2?
What are two common inducers for 1A2?
What is a common inhibitor of 1A2?
What are two common substrates for 2C9?
What are three common inducers for 2C9?
What is a common inhibitor of 2C9?
What is a common substrate for 2C19?
What is a common inducer for 2C19?
What is a common inhibitor of 2C19?
What is a common substrate for 2D6?
What is a common inducer for 2D6?
What are two common inhibitors of 2D6?
What is a common substrate for 2E1?
What is a common inducer for 2E1?
What are two common substrates for 3A4?
What is a common inducer for 3A4?
What are two common inhibitors of 3A4?
CYP enzymes use what kind of reactions in order to biotransform various molecules?
