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Define connective/supportive tissue
What are the four kinds of connective tissue?
What are the five different cells which synthesis ECM?
What does the ECM determine?
List the five roles of ECM?
Describe the secretion of ECM
How is the nature of a tissue changed?
What are the qualities of the dermis and why is this important?
Describe the ECM of:
1) Bone
2) Neural tissue
3) Tendons
4) Dermis
LIst the components you would expect to find in the dermis (6)
What separates the dermis from the epithelial layer (epidermis)?
What is a proteoglycan? Where are they assembled and how are they secreted?
What is the primary function of GAGs and proteoglycans?
Other than resisting compressive forces and lubricating joint cavities, what do GAGs ad proteoglycan gels facilitate?
What is a glycosaminoglycan (GAG)?
What modification has usually been made to disachharides?
Give three examples of GAGs
Give two examples disaccharides which are found in GAGs
What is hyaluronic acid?
Why is it important that cells can migrate through hyaluronic acid? How can this be exploited clinically?
Give three examples of proteoglycans
Of the three examples listed previously, which is the longest? Which is attached to the plasma membrane?
Which GAGs make up:
1) Aggrecan
2) Syndecan
3) Biglycan
Which is the most abundant protein in the human body? What is its primary function?
How many different types of collagen are there? Which is the most common?
What makes up the basement membrane?
What is orthogonal collagen?
What is elastin? What does it form? Where is it commonly found?
What is Marfin syndrome?
What is Ehlers-Danlos syndrome?
What causes wrinkles?
Where are fibronectin fibres found in the body?
What are the functions of fibronectin? (3)
What does the basement membrane underlie?
What is the function of the basement membrane?
What two components make up the basement membrane? How does the basement membrane connect to epithelial cells?
What roles does the basement membrane have? (6)
What is the underlying connective tissue under the basal lamina?
What makes up the basal lamina/basement membrane?
Which laminin in the basal lamina connects to integrin in the epithelial cells?
What is Junctional Epidermolysis Bullosa?
How does a carcinoma in situ turn to malignant cancer?
What are the different types of junctions (and their functions)? (superior to inferior)
In histology exams which tissue will usually be used to demonstrate junctions?
Why is it important that there is a seal between epithelial cells?
What does desmosome related disease result in?
Give an example of an infectious disease targeted at desmosomes
Give an example of an autoimmune disease directed at desmosomes
What is desmoplakin? Which genetic disease can it contribute to?
Where are primary (non-motile) cilia found? What is there function?
Where are motile cilia found?
How do flagella compare to cillia?
Describe the cytoskeleton of cilia and flagella
Give three examples of genetic ciliopathies
What are psuedopodia
What affect do amoeboid cancerous cells have on cancer prognosis?
What are lamellipodia and filopodia important for?
What are the structures that lamellipodia generally referred to as? What type of cells use them?
What are the structures that filopodia form commonly referred to? Which cells use them? What are they predominantly for? When are they abundant?
What are microvilli? Where are they commonly found?
How many microvilli are found on the apical surface of a single small intestinal cell? What affect does this have on surface area?
Describe the structure of microvilli
What causes persistent osmotic diarrhea
What effect do toxins have on intestinal microvilli?
