In depression, remission is defined as:
A period of >3 weeks and <3 months with no clinically depressive symptoms
A period of more than 1 year with no clinically depressive symptoms
A period of >2 weeks and <2 months with no clinically depressive symptoms
A period of 5 months with no clinically depressive symptoms
T or F. Recovery from depression is considered an asymptomatic period of more than 2 months.
T or F. Serotonin receptors are only in the brain.
Thinking of the MOA, the goal of treating depression with SSRI's is:
Induce more sound sleep
Increase the amount of circulating dopamine
Increase the amount circulating serotonin
To increase the amount of serotonin in the re-uptake pump
Prozac has all of the following qualities except (select all that apply):
Most activating
Decreases energy
Causes less weight gain
Wide dosing range
Have no effect on panic or anxiety
T or F. Data supports that weight gain with anti-depressant use is only a side effect of the med.
T or F. Zoloft is considered weight neutral
FDA warning indicates this dose of Celexa may prolong QT interval.
40 mg
20 mg
50 mg
30 mg
Celexa is less attractive option due to:
Poor efficacy
Narrow dosage range
Cost
Availability
T or F. Escitalopram was designed to have less sexual side effects.
Paxil is not used commonly in primary care because (select all that apply):
Difficult to titrate off of
Major weight gain
Pregnancy D category
Patient is uncomfortable if a dose is missed
Patient's do not like it
No longer on the market in US
T or F. The sexual side effects of SSRI's will eventually go away.
SSRI's can cause:
Bothersome GI side effects early on
Decreased seizure threshold
Akathesia
Increased libido
T or F. If SSRI's are combined with MAOI's there is an increased risk for serotonin syndrome.
T or F. SSRI's and NSAID's can never be taken together
The NP should ensure the patient knows the following about SSRI's (select all that apply):
There is an increased risk for suicide in young adults when meds are initiated
Symptoms will not improve all at once
Energy could come back, however mood can remain the same until medicine has more time to work
May initially have more thoughts of SI
Will always make you less anxious
Work immediately
T or F. By week 4 of a dose, the patient will see the most benefit they will ever see of that dose.
What is a good way to assess the effectiveness of the patient's current dose of their anti-depressants?
Ask the patient "Do you feel like there's room for you to feel better?"
Ask the patient's family if it seems like the patient is better
Check a Vitamin D level
Ask the patient, "how is your sleep?"
T or F. The stopping point for titration is based on how the patient feels.
The principles of titration include (select all that apply):
The goal is recovery
The goal is remission
Maximize dose of a single drug before switching
Try low doses of several agents
Effectiveness of a med has more to do with how a patient metabolizes the med
The following are characteristics of cymbalta (select all that apply):
The generic is very expensive
Is an SSRI
Has an indication for pain
Is an SNRI
T or F. Venlafaxine is a commonly used in primary care because of its wide dosing range and low cost.
To work around patients who have an antidepressant medication bias the provider can:
Prescribe a less common anti-depressant like Pristiq
Prescribe the patient whatever drug they request
Prescribe a common anti-depressant like Lexapro
Tell the patient they will take what you prescribe them
SNRI's have the same side effects of SSRI's (weight gain, loss of libido) but also have these additional side effects (select all that apply):
Tremors
Insomnia
Sedation
Urinary incontinence
Sweating
Urinary retention
The provider knows that Effexor has:
The strongest effect on norepinephrine
The strongest effect on dopamine
The weakest effect on norepinephrine
Little effect on BP
T or F. Patient's can experience withdrawal by even missing a single dose of an SNRI.
T or F. There are no renal or hepatic dosing adjustments with SNRI's.
T or F. Antidepressant naive patients should be started on an SSRI.
The following is true of the NDRI, buproprion (select all that apply):
Boosts several neurotransmitters
Is C/I in seizure disorders
Can cause weight loss
Has more sexual side effects
Can interfere with sleep if taken too close to bedtime
Can cause tinnitus
May help patient's quit smoking
Requires patient to reduce consumption of alcohol
T or F. Viibryd's partial agonist action was designed to limit some of the side effects of SSRI's.
Brintellix while having some good emerging efficacy, is not commonly prescribed in primary care due to:
high cost and significant GI effects, that can go away after two weeks
High rate of sexual side effects
Does not work in people for whom SSRI and SNRI's failed
TCA's are not a mainstay of treatment due to what following side effects and cautions (select all that apply)
Risk for overdose
Blurred vision
Excessive thirst
Weight gain
Diarrhea
Constipation
Sedation and dizziness
T or F. MAOI's are not commonly prescribed as they have interact with several drugs.
It is important for patient's to understand this about taking anti-depressant to increase adherence:
These meds are not "Tylenol or Advil", they will take time to work
You can stop and start the meds if you like
They will work immediately
They can expect few if any side effects.
T or F. True Serotonin Syndrome develops rapidly over 24 hours
The following are signs and symptoms of serotonin syndrome (select all that apply):
Mental status changes (anxiety, agitation, delirium, restlessness, disorientation
Autonomic hyperactivity (diaphoresis, tachycardia, hyperthermia, hypertension, vomiting and diarrhea)
Neuromuscular abnormalities (tremor, muscle rigidity, myoclonus, hyperreflexia, and bi-lateral Babinski sign)
Sleep disturbances
Polyphagia
T or F. The provider should maximize the dose of drug before changing or adding drugs.
For these patients, you might consider starting them at lower doses of antidepressants (select all that apply):
Older adults
Frail or underweight adults
Women
Adolescents
Patient or provider med anxiety
The rule of thumb for when to switch a patient to another anti-depressant is:
No symptom improvement after 2 dose adjustments AND patient is still safe (no S/I)
The first time the patient tells you the med is not working
When a friend tells them about one that will work better
After one dose adjustment AND patient is still safe (no S/I)
The provider can consider adding Wellbutrin to an SSRI/SNRI if:
If the patient requests it
If the dose of the first agent is at its max, and patient has residual symptoms and sexual side effects are bothersome
Can only add to an SNRI
Can only add to an SSRI
T or F. If a patient has a full resolution of depressive symptoms the provider should keep their medication at the same dose.
With a partial resolution of depressive symptoms the provider should first:
Increase the dose
Keep the same dose, but give it more time to work
Change medications
Add Wellbutrin
T or F. if a patient's depressive symptoms are not better, but not worse either, the provider should keep the patient's dose the same.
If a patient is started on an anti-depressant and returns to your office and tells you they have been up for days and they just bought two (2) new Corvette's, the provider is concerned:
The medication unmasked bipolar disorder with a first episode of hypomania or mania.
Not concerned. The patient is just adjusting to the meds.
The patient is developing Serotonin Syndrome.
The patient is just not on the right anti-depressant and needs a medication change.
T or F. After a 1st lifetime depressive episode, it is reasonable to trial off agent after 6 months to a year.
T or F. SSRI's and SNRI's are FDA approved for anxiety, but usually require lower doses.
The provider knows that when prescribing an SNRI or SSRI to a patient for the first time with anxiety, the medication can cause:
A paradoxical antidepressant effect and make them feel worse
Increased hunger
Episodic tinnitus
A non-benzodiazipine option for treating anxiety is:
Effexor
Zoloft
Librium
BuSpar
T or F. It can take 1-2 weeks for a patient to feel a therapeutic effect from BuSpar.
The provider knows the following is true about benzodiazipines:
Xanax has the shortest half-life and Valium has the longest half-life
Klonopin has a shorter half-life than Ativan
The patient can discontinue them on their own
Ativan has a shorter half-life than Xanax.
Which benzo is used commonly used for alcohol detox due to its long half-life?
Valium
Klonopin
Ativan
Xanax
T or F. Benzodiazipines should not be used for more than 12 weeks.
T or F. There are no withdrawal symptoms from stopping benzos.
A anti-depressant that is known to be effective for sleep in lower doses is:
Viibyrd
Trazadone
Celexa
T or F. Trazadone is good for early or middle insomnia.
T or F. If a patient has a history of using benzo's they will probably find trazadone very effective for sleep.
T or F. A rare side effect of trazadone is priapism.
This medication is an attractive choice for older women who have insomnia and diminished appetite:
Remeron
Melatonin
Ambien
The provider knows that lower doses of Remeron can cause:
Significant weight gain
Are weight neutral
Cause significant weight loss
Are ineffective for sleep
T or F. Ambien has the potential for causing amnesia and odd behaviors.
A controlled substance used for sleep, that may become habit forming and should be prescribed for short term use is:
Zolpidem
T or F. There is a risk of developing hyponatremia with the use of Trileptal.
For patients on Depakote, the PMHNP knows they should monitor their patients LFT's, platelets and plasma levels:
every 6-12 months
at baseline, 1 month and q6months
baseline and then annually thereafter
They only need to monitor platelets.
T or F. There is a risk for Stevens-Johnson Syndrome in patient's taking Lamictal.
With Lithium the following is true (select all that apply):
Electrolytes should be monitored (Na+, K+, Mg and P levels)
Can be nephrotoxic
Patient should have a thyroid panel every 6 months
Is teratogenic in the 1st trimester
NSAIDS, ACEI, diuretics and CCB may cause increased plasma levels,
Elderly people require lower dose for therapeutic response
T or F. Atypical anti-psychotics can and should be prescribed by PCP's
T or F. One dose of olanzapine (Zyprexa) can raise blood sugar.
If a patient is taking an atypical anti-psychotic, the provider should monitor for and counsel patient on:
Potential for metabolic syndrome and weight gain
Potential for weight loss
The cost and availability of the meds
Risk for hypoglycemia
The following atypical anti-psychotics have the biggest risk for metabolic adverse reactions (select all that apply):
Olanzapine (Zyprexa)
Quetapine (Seroquel)
Risperidone (Risperdal)
Aripiprazole (Abilify)
Ziprasidone (Geodon)
Lurasidone (Latuda)
Metabolic Syndrome is defined as:
A constellation of symptoms, abdominal obesity with 2 of 4 of the following symptoms: elevated triglycerides, reduced HDL, elevated BP and elevated fasting blood glucose
Abdominal obesity and elevated BP only
High triglycerides, low HDL and high fast blood glucose
Abdominal obesity only (greater than 35 inches in women and 40 inches in men)
T or F. The PMHNP should get a baseline ECG before initiating Geodon due to risk for prolonged QT interval.
T or F. Before prescribing meds for migraines, the NP should advise the patient to maintain a migraine diary.
The following is true for migraine rescue agents (select all that apply):
Are taken to abort a migraine
A single larger dose is more helpful than smaller doses
Most helpful when taken soon after symptom onset
More helpful in smaller doses than a single large dose
Probably won't help
T or F. Excedrin migraine has about the same amount of caffeine as two diet cokes or 1 cup of coffee.
T or F. Triptans are vasoconstrictors and block pain pathways in the brainstem.
The following is true in the use of triptans like Imitrex (select all that apply):
Cannot exceed 200 mg in 24 hours
Can take one dose of any strength followed by a second dose, typically of the same strength of the 1st dose, 2 hours later
Should consider upping to max dose for next migraine event if 2nd dose was ineffective
If there is no relief, even after changing meds, refer to neurologist
In the use of triptans for migraines the provider should teach the patient to:
Take at the first sign of headache pain
Take an hour after symptoms have started
Take before the symptoms start
Are indicated in patients with a history of ischemic stroke
T or F. Uncontrolled HTN, Prinzmetal's Angina and Pregnancy are all contraindications in the use of Triptans for migraines.
While it is probably safe to take Triptans with SSRI's, SNRI's and anti-psychotics the NP should tell the patient to watch for:
Elevated pulse and sweating
Decreased pulse and decreased blood pressure
T or F. Triptans should not be taken with MAOI's and and within 24 hours of Ergots
T or F. Rescue migraine agents for any class should not be used for more than 10 days per month due to risk for rebound headache
T or F. Migraine prophylaxis is neurologist driven and should be considered in patients who frequent, long lasting and who have significant impairment from their migraines.
The following are common migraine prophylaxis agents (select all that apply):
Beta blockers
CCB
TCAS/SSRI's/SNRI's
Anticonvulsants (valprote, gabapentin, and topiramate)
NSAIDS
ASA
T or F. Mostly common anti-seizure medications are protein bound and require monitoring to ensure therapeutic levels.
Along with providing seizure protection, which two medications also help with mood stabilization:
Lamictal and Depakote
Dilantin and Keppra
Topamax and Depakote
Dilantin and Trileptal
T or F. Cholinesterase Inhibitors like Aricept, Exelon and Razadyne are indicated for mild-severe dementia and reduce the amount of acetylcholine breakdown in the brain.
The most common side effects with Cholinesterase Inhibitors are:
GI, may present as dyspepsia or as anorexia and weight loss
Headache and blurry vision
Puritis and urticaria
Numbness in extremities
T or F. With Namenda common side effects include constipation, headache, dizziness and pain.
Because Levadopa compete with amino acids for absorption, it is best to take them:
Without food, especially protein
With food, especially protein
With dairy products
Not with dairy products
T or F. The dykinesias a Parkinson's patient can have are more commonly associated with their use of levodopa and not their disease.