Undergraduate BMS 381 Developmental neurobiology (AF lectures) Flashcards on Axon guidance, created by Kristi Brogden on 13/08/2014.
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Created by Kristi Brogden
over 9 years ago
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Created by Kristi Brogden
over 9 years ago
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What was sperry's hypothesis?
What was weiss's hypothesis?
What proof is there that sperry was right? (3)
Describe sperry's frog experiment and its results
Describe an experimental approach that shows us that motor axons are guided specifically to their targets in the chick embryo
What are the main ideas involved in the labelled pathway hypothesis?
Describe an example of the importance of axon scaffolds in vertebrates
Describe evidence from the grasshopper embryo limb that pioneer axons also follow stereotyped paths
What boundries do axons follow in the forebrain?
What boundries do axons follow in the hindbrain?
What boundries do axons follow in the spinal cord?
What are the four forces of axon guidance?
How are the actin bundles arranged in lamella(podium)?
How are the actin bundles arranged in filopodia?
Describe a model of how actin treadmilling may control filopodial extension?
What happens to F-actin when a growth cone collapses?
What are 2 of the main different 'flavours' of semaphorins?
Which type of semaphorins can cause growth cones to turn?
What is laminin and where is an example of where it is localised?
What is the evidence that laminin only dictates where axons can grow, not the direction of axon growth?
What is the evidence that non-permissive factors such as semaphorins can channel axon growth?
What are ephrins?
What is netrin?
What evidence is there that axons reprogram when intermediate targets (choice points) are encountered?
What evidence is there that axons reprogram when intermediate targets (choice points) are encountered?
What does the roundabout gene robo encode and where is it expressed?
What happens in robo mutants (no robo protein made)
Where is comm expressed?
What happens in a comm mutant (comm missing)
What happens if comms expression is forced in all neurons?
How is robo prevented from functioning before midline crossing in flies and mice?
Why is robo prevented from functioning before midline crossing in flies and mice?
Where and when is the vertebrate homolog robo1 expressed?
What is the comm homolog in vertebrates?
What does Fasciclin II control?
How do we know that Fas II adhesion also controls defasciculation?
What are the two types of targets?
What evidence is there for discrete targets?
What are topographic maps?
What were sperrys theories about how topographic maps are acheived?
Why is the labels theory implausible?
What evidence is there for gradients?
