Lecture 2 - updated - glomerular filtration

Question 1 of 43

1

What is the filtration barrier formed by?

Select one or more of the following:

fenestrated vascular endothelium
basement membrane
podocytes separated by slits
organocytes
endometrium

Explanation

Question 2 of 43

1

What is the basement membrane of the filtration barrier formed by?

Select one or more of the following:

proteins such as collagen
proteins such as laminin
extracellular matrix proteins such as negatively charged heparan sulfate proteoglycans
starchy carbohydrates
endometrium

Explanation

Question 3 of 43

1

What does the basement membrane of the filtration barrier provide?

Select one of the following:

a charge barrier
a source of energy
a microphalange
urine

Explanation

Question 4 of 43

1

What type of function does the basement membrane of the filtration barrier have?

Select one of the following:

a sieving function
a saving function
a blocking function
a stimulating function
a reduction function

Explanation

Question 5 of 43

1

Determinants of glomerular filtration.

❌ = ❌ x ❌( Δ ❌ - Δ ❌ )

Drag and drop to complete the text.

Jv

k

S

P

Π

Explanation

Question 6 of 43

1

In the determinants of glomerular filtration formula, Jv =

Select one of the following:

flux
hydraulic conductivity
hydraulic pressure
surface area

Explanation

Question 7 of 43

1

In the determinants of glomerular filtration formula, k =

Select one of the following:

flux
hydraulic conductivity
hydraulic pressure
surface area
gradient

Explanation

Question 8 of 43

1

In the determinants of glomerular filtration formula, S =

Select one of the following:

surface area
flux
oncotic pressure
gradient
hydraulic pressure

Explanation

Question 9 of 43

1

In the determinants of glomerular filtration formula, P =

Select one of the following:

hydraulic pressure
oncotic pressure
hydraulic conductivity
flux

Explanation

Question 10 of 43

1

In the determinants of glomerular filtration formula, Π =

Select one of the following:

oncotic pressure
flux
hydraulic pressure
surface area
hydraulic conductivity

Explanation

Question 11 of 43

1

Hydraulic conductivity is defined as the ❌ of ❌ (❌) per unit ❌ for a defined ❌ gradient and ❌ area.

Drag and drop to complete the text.

flux

water

and small solutes

time

pressure

surface

Explanation

Question 12 of 43

1

The hydraulic conductivity of the glomerular capillary wall is _________ fold higher than other capillaries.

Select one of the following:

40 - 50
90-100
10-20
5-6
20-25

Explanation

Question 13 of 43

1

Glomerular capillaries work at _____ pressures than other capillaries

Select one of the following:

higher
lower
the same

Explanation

Question 14 of 43

1

Hydrostatic pressure in glomerular capillaries is relatively _________

Select one of the following:

constant
variable

Explanation

Question 15 of 43

1

Colloid oncotic pressure ________ in the glomerular capillaries

Select one of the following:

increases
decreases
stays constant

Explanation

Question 16 of 43

1

label the pressures

Drag an answer into the correct orange point.

Glomerular capillary pressure

colloid oncotic pressure

bowman's space pressure

net filtration pressure

Explanation

Question 17 of 43

1

What controls Glomerular Capillary Pressure?

Select one of the following:

relative resistances of Afferent Arteriole and Efferent Arteriole
relative blood flow of Afferent Arteriole and Efferent Arteriole
space in the glomerulus
amount of urine produced

Explanation

Question 18 of 43

1

What controls resistances of afferent arteriole and efferent arteriole?

Select one of the following:

neural and hormonal inputs
glomerular capillary pressure
blood flow
vaso constriction and dilation

Explanation

Question 19 of 43

1

What affect does changes in resistance of the afferent arteriole and efferent arteriole have?

Drag an answer into the correct orange point.

lower than if equal resistances

higher than if equal resistances

equal to if equal resistances

Explanation

Question 20 of 43

1

Why is it so important to control and maintain the Glomerular Capillary Pressure constant?

Select one of the following:

to ensure GFR is constant
to avoid excess unnecessary urine being made
to avoid pain
to maintain an equal level of hormones

Explanation

Question 21 of 43

1

Which graph relates to afferent arteriole constriction and which relates to efferent arteriole constriction?

Drag an answer into the correct orange point.

afferent arteriole constriction

efferent arteriole constriction

Explanation

Question 22 of 43

1

A 25% increase in mean arterial blood pressure will cause a __% increase in GFR and a loss of L per day.

Select one of the following:

25%, 40L
50%, 80L
75%, 100L
2.5%, 4L

Explanation

Question 23 of 43

1

What are the 3 important mechanisms in regulating GFR?

Select one or more of the following:

renin-angiotensin system
autoregulation
sympathetic nerves
sodium-water system
reduction of blood volume by osmosis

Explanation

Question 24 of 43

1

The movement of any molecule across the filtration membrane is measured by its ❌

Drag and drop to complete the text.

flux

hydraulic conductivity

speed

molecular weight

oncotic pressure

Explanation

Question 25 of 43

1

Hydraulic conductivity is very _____ in glomerular capillaries

Select one of the following:

high
low
changeable
constant
annoying

Explanation

Question 26 of 43

1

Hydrostatic pressure gradient is the gradient acting ....

Select one of the following:

between the inside and outside of the capillary and bowmans space.
between the glomerulus and afferent arteriole
between the efferent and afferent arteriole
between the inside and outside of the capillary
between the inside and outside of bowmans space.

Explanation

Question 27 of 43

1

Kf in relation to GFR is...

Select one of the following:

ultrafiltration coefficient
net ultrafiltration pressure
net friction along capillary walls
hydrostatic pressure.

Explanation

Question 28 of 43

1

Label

Drag an answer into the correct orange point.

other

glomerular

capillary hydrostatic pressure

filtration pressure equilibrium

capillary colloid osmotic pressure

glomerular capillaries

Explanation

Question 29 of 43

1

Label

Drag an answer into the correct orange point.

glomerular capillary hydrostatic pressure

Bowman’s space oncotic pressure

Bowman’s space hydrostatic pressure

glomerular capillary oncotic pressure

efferent arteriole

afferent arteriole

Explanation

Question 30 of 43

1

There is net filtration along the entire length of the glomerular capillaries

Select one of the following:

True
False

Explanation

Question 31 of 43

1

Net filtration pressure = ❌ - ( ❌ + ❌ )

Drag and drop to complete the text.

glomerular capillary pressure

colloid oncotic pressure

Bowman’s space pressure

Explanation

Question 32 of 43

1

Label grr regulation graph

Drag an answer into the correct orange point.

autoregulation range

relative vascular resistance

GFR

RPF

Explanation

Question 33 of 43

1

Label

Drag an answer into the correct orange point.

renal corpuscle

renal sympathetic nerve

afferent arteriole

juxtaglomerular cells

macula densa

efferent arteriole

Explanation

Question 34 of 43

1

Granular juxtamedullary cells are...

Select one or more of the following:

Located in afferent arteriole
Store and secrete renin
Their effects result in angiotensin 2 formation
Decrease sodium absorption

Explanation

Question 35 of 43

1

The granular juxtamedullary cells ...

Select one or more of the following:

Directly increase total PR
Directly increase systemic blood pressure
Indirectly increase sodium reabsorption
Indirectly increase potassium secretion
Indirectly increase ECF volume
Secrete ADH

Explanation

Question 36 of 43

1

Auto-regulation of GFR ... ❌ —-> ❌ —> ❌—> ❌

Drag and drop to complete the text.

increased stretch in afferent

afferent contraction

decreased pressure

no change in GFR

Explanation

Question 37 of 43

1

Fill in flow chart...

Drag an answer into the correct orange point.

up fluid delivery sensed by macula densa

ATP

afferent contraction

decreased pressure

decreased GFR

decreased fluid flow

GFR Returns to normal

Explanation

Question 38 of 43

1

The macula densa senses fluid flow in the tubule

Select one of the following:

True
False

Explanation

Question 39 of 43

1

Label

Drag an answer into the correct orange point.

fight or flight reaction

cardiovascular shock

increased sympathetic activity

vasoconstriction

AA and EA constricts

decreased RPF

decreased GFR

Explanation

Question 40 of 43

1

Alport's syndrome is ...

Select one or more of the following:

hereditary glomerulonephritis
due to mutations in the collagen chains of the glomerular basement membrane
a pathological condition
an inability to process proteins

Explanation

Question 41 of 43

1

Which of these are protein elements that can be found in the glomerular basement membrane?

Select one or more of the following:

laminin
nidogen
entactin

Explanation

Question 42 of 43

1

Which of these are true about the endothelial cell surface layer?

Select one or more of the following:

aka ESL
seems to be a rather thick negatively charged structure
most likely contributes to the high permselectivity of the glomerular wall
is found on the luminal side of blood vessel walls
it is never found in venules

Explanation

Question 43 of 43

1

Small molecular weight neutral solutes have concentrations in the filtrate equal to those in plasma, this means they are freely filtered.

Select one of the following:

True
False

	Created by Alannah McDonnell over 8 years ago

- Renal physiology Quiz on Lecture 2 - updated - glomerular filtration, created by Alannah McDonnell on 05/04/2018.

Lecture 2 - updated - glomerular filtration

Question 1 of 43

What is the filtration barrier formed by?

Select one or more of the following:

Explanation

Question 2 of 43

What is the basement membrane of the filtration barrier formed by?

Select one or more of the following:

Explanation

Question 3 of 43

What does the basement membrane of the filtration barrier provide?

Select one of the following:

Explanation

Question 4 of 43

What type of function does the basement membrane of the filtration barrier have?

Select one of the following:

Explanation

Question 5 of 43

Determinants of glomerular filtration. ❌ = ❌ x ❌( Δ ❌ - Δ ❌ )

Drag and drop to complete the text.

Explanation

Question 6 of 43

In the determinants of glomerular filtration formula, Jv =

Select one of the following:

Explanation

Question 7 of 43

In the determinants of glomerular filtration formula, k =

Select one of the following:

Explanation

Question 8 of 43

In the determinants of glomerular filtration formula, S =

Select one of the following:

Explanation

Question 9 of 43

In the determinants of glomerular filtration formula, P =

Select one of the following:

Explanation

Question 10 of 43

In the determinants of glomerular filtration formula, Π =

Select one of the following:

Explanation

Question 11 of 43

Hydraulic conductivity is defined as the ❌ of ❌ (❌) per unit ❌ for a defined ❌ gradient and ❌ area.

Drag and drop to complete the text.

Explanation

Question 12 of 43

The hydraulic conductivity of the glomerular capillary wall is _________ fold higher than other capillaries.

Select one of the following:

Explanation

Question 13 of 43

Glomerular capillaries work at _____ pressures than other capillaries

Select one of the following:

Explanation

Question 14 of 43

Hydrostatic pressure in glomerular capillaries is relatively _________

Select one of the following:

Explanation

Question 15 of 43

Colloid oncotic pressure ________ in the glomerular capillaries

Select one of the following:

Explanation

Question 16 of 43

label the pressures

Drag an answer into the correct orange point.

Explanation

Question 17 of 43

What controls Glomerular Capillary Pressure?

Select one of the following:

Explanation

Question 18 of 43

What controls resistances of afferent arteriole and efferent arteriole?

Select one of the following:

Explanation

Question 19 of 43

What affect does changes in resistance of the afferent arteriole and efferent arteriole have?

Drag an answer into the correct orange point.

Explanation

Question 20 of 43

Why is it so important to control and maintain the Glomerular Capillary Pressure constant?

Determinants of glomerular filtration.

❌ = ❌ x ❌( Δ ❌ - Δ ❌ )

A 25% increase in mean arterial blood pressure will cause a __% increase in GFR and a loss of L per day.