what is metabolism and pharmokinetics

What does ADME stand for? +2 bonus

defiintion of each ADME?
PT1 ADM

defintion of ADME?
PT2 E +2bonus

what is the main goal of DMPK

Whats the difference between in VITRO and in VIVO

what are 8 industry standard in vitro DMPK areas to assay

what are the measured physiochemcal properties

What is checked for in chemical stability assays

what is checked for in permeability

whats checked for in metabolism assays

what is checked ofr in cDDI and bioactivation risk assays

whats protein binding assays looking for
and whats PgP looking for

difference between doses in vitro and in vivo?

what are the results from:
1)poor absorption or extenisive first pass metabolism
2)inappropriate distribution
3)large dist. vol/ tissue uptake
4) high protein binding
5) rapid systemic clearance

what is an ideal drug

What should a target product profile include?

what are 3 structural features that determines its physical props

what will increasing charge, ionisation or hydrogen bonding capacity do to a molecule?

what will increasing lipophilicity do ?

effects of increasing lipophilicity

what is renal clearance important for

if logD7.4 is greater than 0 what is the renal clearance

if LogD7.4 is less than 0 what is the renal clearance

what are lipinskis rules

for monikas rules whats the acceptable rotatable bonds and

what is the general guide for lipophilicity when Log D7.4 is <1

what is the general guide for lipophilicity when Log D7.4 is between 1 and 3

what is the general guide for lipophilicity when Log D7.4 is between 3 and 5

what is the general guide for lipophilicity when Log D7.4 is >5

what kind of drugs will passively cross a membrane?

how do molecules diffuse through a lipid membrane

what is polar surface area defined as

Solubility is a determinant of

how can solubility be increased

name 5 things that low solubility can result in

what is kinetic solubility

name 4 kinetic solubility advantages

how is a kinetic solubility tested

name an advantage and 3 disadvanatges to kinetic aqueous solubility using laser nephelometry

name 7 strategies to increase solubility

8 strategies to improve permeability