What are the 3 initial responses to vascular injury?

Intrinsic Pathway

Extrinsic Pathway

Common Pathway

Prothrombin Complex

What does fibrin do?

What does Factor XIII do?

Effects of Thrombin

Effects of Antithrombin III

Effects of Heparin on Antithrombin III

Protein C

Protein S

Molecules associated with fibrinolysis

Tissue Plasminogen Activator

Plasmin

Alpha-2 Antiplasmin

Factor with the shortest half-life

What factors are lost in stored blood but not FFP?

Which factor is not synthesized in the liver?
Where is it synthesized?

Which Factors are Vitamin K dependent?

How long does it take for Vitamin K in IV form take to have an effect?

What is Factor II?

Normal half-life of RBC

Normal half-life of platelets

Normal Half-life of PMNs

Prostacyclin
- where is it from?
- what effects does it have?

Thromboxane (TXA2)
- where is it from?
- what are its effects?

GpIIb/IIIa receptor

GpIb Receptor

Cryoprecipitate
- what does it contain?
- What diseases is it commonly used for?

FFP

DDAVP and conjugated estrogens release which factors?

What does prothrombin time (PT) measure?

What does partial thromboplastin time measure?
What range do we want?

Activated Clotting Time we want for routine A/C vs for cardiopulmonary bypass

relative contraindication to performing surgical procedures (INR)

Relative contraindication for placing a central line, percut. needle biopsies, and eye surgery

MCC of surgical bleeding

MC congenital bleeding disorder

MC symptom associated with vWD

Which type(s) of vWD are autosomal dominant?

Which type(s) of vWD are autosomal recessive?

Effects of vWF

Effects of vWD on PT and PTT

Effects of vWD on bleeding time

MC type of vWD

Which type of vWD is most severe?

What is Type I vWD?
and it's treatment

What is Type II vWD?
what is its treatment?

what is Type III vWD?
Treatment?

What is Hemophilia A?
MC symptom?

PT and PTT in Hemophilia A

What to do for Hemophiliac joint bleeding

Treatment for Hemophiliac epistaxis, ICH, or hematuria

Hemophilia B
and treatment

PT and PTT in Hemophilia B

Factor VII deficiency
PT & PTT, and treatment

Symptoms associated with Platelet Disorders

What can cause acquired thrombocytopenia

What is Glanzmann's Thrombocytopenia?
Its treatment

Bernard Soulier and its treatment

Uremia and its effect on platelets
Treatment

Antibody associated with HIT syndrome

Difference between HIT and HITT

Clinical Signs of HIT

Type a clot that is formed associated with HIT syndrome

Diagnostic Testing for HIT syndrome

Treatment of HIT syndrome

What is DIC?
What is increased and decreased on bloodwork?

Treatment for DIC

When do you stop aspirin before surgery?

MoA and Effects of aspirin

When to Stop Clopidogrel (Plavix) before surgery

MoA of clopidogrel

How to treat someone for bleeding while on Clopidogrel/Plavix

What to do for a patient with coronary stent and need to stop Plavix for elective surgery?

Treatment for bleeding in a patient on Coumadin

When to stop Coumadin prior to surgery

Platelet levels prior to surgery
and after surgery

Effects of prostate surgery on coagulation

Best way to predict bleeding risk

MC congenital hypercoagulability disorder

Effects of Factor Leiden V mutation

Tx for Factor Leiden V mutation

Effects of hyperhomocysteinemia and treatment for it

Prothrombin gene defect G20210A

Treatment of G20210A

Treatment of Protein C or S deficiency

Polycythemia Vera

What platelet and Hct levels are expected in patients with Polycythemia Vera prior to surgery?

Treatments for Polycythemia Vera

Symptoms with Anti-phospholipid antibody syndrome

Antibodies associated with anti-phospholipid antibody syndrome

Diagnostic Tests for Anti-phospholipid Ab Syndrome (not antibodies)

Treatment for anti-phospholipid antibody syndrome

MC factor for acquired hypercoagulability

Name 10 Causes of Acquired Hypercoaguable states

Warfarin-induced skin necrosis

Tx of Warfarin-induced skin necrosis

Virchow's Triad

Key element in the development of arterial thrombosis

Indications for IVC filter placement

How to treat someone for DVT post-op
1st time?
2nd time?
3rd time?

MC origin for PE

Aminocaproic Acid (amicar)
MoA

When to use Aminocaproic Acid

MoA of Warfarin

List 3 direct thrombin inhibitors
(PO)

How do sequential compression devices (SCDs) work?

How to reverse heparin

Half-life of heparin

How is heparin cleared from the system?

Protamine Reaction

which anticoagulant is safer to use in pregnancy? and why?
Heparin or Warfarin

Low Molecular Weight Heparin

Argatroban

Bivalirudin
(Angiomax)

Hirudin (Hirulog)

Ancrod

3 thrombolytics

Absolute Contraindications for Thrombolytics

Major Contraindications
to Thrombolytic Use

Minor Contraindications to Thrombolytics