Haemolysis

Question 1 of 24

1

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The shape of a normal red cell is described as

Explanation

Question 2 of 24

1

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Red blood cells have no mitochondria and thus rely on the process of for energy

Explanation

Question 3 of 24

1

Once in circulation, the red blood cell is unable to generate new proteins, thus if it is damaged it cannot be fixed.

Select one of the following:

True
False

Explanation

Question 4 of 24

1

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When the body deals with increased red cell destruction by means of increased red cell production this is known as haemolysis.

Explanation

Question 5 of 24

1

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Increased rate of red cell destruction exceeding bone marrow capacity for red cell production = Anaemia

Explanation

Question 6 of 24

1

Fill the blank space to complete the text.

Increased bone marrow red cell production is known as

Explanation

Question 7 of 24

1

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The most common supravital stain is performed on reticulocytes using ( New Methylene Blue, Hoechst, Gimenez, Malachite green ) stain

Explanation

Question 8 of 24

1

Haemolysis can be classified as extravascular (taken up by reticuloendothelial system) or intravascular (destroyed within circulation). Which two of the following organs are the main sites of extravascular haemolysis.

Select one or more of the following:

Liver
Spleen
Pancreas
Kidneys

Explanation

Question 9 of 24

1

Extravascular Haemolysis in more common and results in hyperplasia at the site of destruction (e.g. Splenomegaly, Hepatomegaly)

Select one of the following:

True
False

Explanation

Question 10 of 24

1

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Haemoglobinuria (Hb in the urine) is ( pink, orange, rainbow ) in colour, however when left to stand gradually turns to ( black, brown, yellow, orange )

Explanation

Question 11 of 24

1

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When in suspicion of an immune-mediated hemolytic anemia, a clinician can confirm or deny this hypothesis by conducting a Coomb's Test

Explanation

Question 12 of 24

1

Fill the blank spaces to complete the text.

haemolysis: Immune response to nonself antigens from members of the same species
haemolysis: Immune response of an organism against its own healthy cells

Explanation

Question 13 of 24

1

Fill the blank spaces to complete the text.

Autoimmune Haemolysis can be either 'warm' or 'cold'
Warm Autoimmune Haemolysis is mediated by Ig
Cold Autoimmune Haemolysis is mediated by Ig

Explanation

Question 14 of 24

1

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Haemolytic Transfusion Reaction:
Immediate Reaction is typically ( IgM, IgG ) mediated and occurs predominantly ( intravascularly, extravascularly )
Delayed Reaction is typically ( IgG, IgM ) mediated and occurs predominantly ( extravascularly, intravascularly )

Explanation

Question 15 of 24

1

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E.coli O157 infection can cause an anaemic state via destruction of RBCs, platelets all whilst bringing about kidney failure. This is called

Explanation

Question 16 of 24

1

Microspherocytes are red cells that have been damaged as they pass through damaged capillaries. This typically occurs in which type of event?

Select one of the following:

Tissue Hypoxia
Severe Burns
Drowning

Explanation

Question 17 of 24

1

Zieve's Syndrome is a haemolytic anaemia which occurs with hyperlipidaemia and jaundice in response to withdrawal from ...

Select one of the following:

Heroin
Alcohol
Amphetamines
Benzodiazepines

Explanation

Question 18 of 24

1

Fill the blank space to complete the text.

Name the condition:
An inherited abnormality of the red blood cells whereby there are defects in the membrane structure, causing the formation of spherical red blood cells. These abnormal cells are removed by the spleen and thus have a very short lifespan, sometimes only around 10 days.
This condition is called

Explanation

Question 19 of 24

1

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The normal lifespan of a red blood cell is around days.

Explanation

Question 20 of 24

1

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Which drug, used primarily in the treatment of dermatitis herpetiformis, can cause a haemolytic anaemia?

Explanation

Question 21 of 24

1

Fill the blank spaces to complete the text.

Sickle cell disease is caused by a mutation in a globin chain.

Explanation

Question 22 of 24

1

The bony deformities of this child's face are in keeping with which haematological condition?

Select one of the following:

Beta Thalassaemia Major
HbH Disease
Hb Barts Hydrops Fetalis
Chronic Iron Deficiency Anaemia

Explanation

Question 23 of 24

1

Fill the blank space to complete the text.

Diagnose this patient:
A 22 year old female presented to the GP with intermittent mild jaundice which her partner had noticed. She has a PMX of gallstones and on examination she is found to have splenomegaly. Upon further questioning it was found that her father had had his spleen removed at a young age.
This woman is likely suffering from

Explanation

Question 24 of 24

1

Fill the blank space to complete the text.

These 'golf ball cells' that are labelled on the diagram are red blood cells with abnormal haemoglobin inside of them. If I told you that the patient was a young thai girl who has intermittent jaundice when she unwell, what would your diagnosis be?

	Created by Matthew Coulson about 5 years ago

Honours Degree Medicine (Haematology - Week 1) Quiz on Haemolysis, created by Matthew Coulson on 01/03/2019.

Question 1 of 24

Fill the blank space to complete the text.

The shape of a normal red cell is described as

Explanation

Question 2 of 24

Fill the blank space to complete the text.

Red blood cells have no mitochondria and thus rely on the process of for energy

Explanation

Question 3 of 24

Once in circulation, the red blood cell is unable to generate new proteins, thus if it is damaged it cannot be fixed.

Select one of the following:

Explanation

Question 4 of 24

Fill the blank space to complete the text.

When the body deals with increased red cell destruction by means of increased red cell production this is known as haemolysis.

Explanation

Question 5 of 24

Fill the blank space to complete the text.

Increased rate of red cell destruction exceeding bone marrow capacity for red cell production = Anaemia

Explanation

Question 6 of 24

Fill the blank space to complete the text.

Increased bone marrow red cell production is known as

Explanation

Question 7 of 24

Select from the dropdown list to complete the text.

The most common supravital stain is performed on reticulocytes using New Methylene Blue Hoechst Gimenez Malachite green( New Methylene Blue, Hoechst, Gimenez, Malachite green ) stain

Explanation

Question 8 of 24

Haemolysis can be classified as extravascular (taken up by reticuloendothelial system) or intravascular (destroyed within circulation). Which two of the following organs are the main sites of extravascular haemolysis.

Select one or more of the following:

Explanation

Question 9 of 24

Extravascular Haemolysis in more common and results in hyperplasia at the site of destruction (e.g. Splenomegaly, Hepatomegaly)

Select one of the following:

Explanation

Question 10 of 24

Select from the dropdown lists to complete the text.

Haemoglobinuria (Hb in the urine) is pink orange rainbow( pink, orange, rainbow ) in colour, however when left to stand gradually turns to black brown yellow orange( black, brown, yellow, orange )

Explanation

Question 11 of 24

Fill the blank space to complete the text.

When in suspicion of an immune-mediated hemolytic anemia, a clinician can confirm or deny this hypothesis by conducting a Coomb's Test

Explanation

Question 12 of 24

Fill the blank spaces to complete the text.

haemolysis: Immune response to nonself antigens from members of the same species haemolysis: Immune response of an organism against its own healthy cells

Explanation

Question 13 of 24

Fill the blank spaces to complete the text.

Autoimmune Haemolysis can be either 'warm' or 'cold' Warm Autoimmune Haemolysis is mediated by Ig Cold Autoimmune Haemolysis is mediated by Ig

Explanation

Question 14 of 24

Select from the dropdown lists to complete the text.

Explanation

Question 15 of 24

Fill the blank space to complete the text.

E.coli O157 infection can cause an anaemic state via destruction of RBCs, platelets all whilst bringing about kidney failure. This is called

Explanation

Question 16 of 24

Microspherocytes are red cells that have been damaged as they pass through damaged capillaries. This typically occurs in which type of event?

Select one of the following:

Explanation

Question 17 of 24

Zieve's Syndrome is a haemolytic anaemia which occurs with hyperlipidaemia and jaundice in response to withdrawal from ...

Select one of the following:

Explanation

Question 18 of 24

Fill the blank space to complete the text.

Explanation

Question 19 of 24

Fill the blank space to complete the text.

The normal lifespan of a red blood cell is around days.

Explanation

Question 20 of 24

Fill the blank space to complete the text.

Which drug, used primarily in the treatment of dermatitis herpetiformis, can cause a haemolytic anaemia?

Explanation

The most common supravital stain is performed on reticulocytes using ( New Methylene Blue, Hoechst, Gimenez, Malachite green ) stain

Haemoglobinuria (Hb in the urine) is ( pink, orange, rainbow ) in colour, however when left to stand gradually turns to ( black, brown, yellow, orange )

haemolysis: Immune response to nonself antigens from members of the same species
haemolysis: Immune response of an organism against its own healthy cells

Autoimmune Haemolysis can be either 'warm' or 'cold'
Warm Autoimmune Haemolysis is mediated by Ig
Cold Autoimmune Haemolysis is mediated by Ig