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Clinical Immunology Final MCQs- 4th Year- PMU

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Clinical Immunology Final MCQs- 4th Year- PMU

Question 1 of 58

1

Which of the following methods is suitable for detectin of serum globulins?

Select one or more of the following:

  • Nephelometry

  • Radial immnodiffusion by manchini

  • Turbidimetry

  • NBT-test

  • The mantoux test

Explanation

Question 2 of 58

1

Type II allergic reations are realized by

Select one of the following:

  • anaphylaxis

  • complement-mediated cytolysis

  • immune complexes

  • infectious immunity

Explanation

Question 3 of 58

1

Monoclonal antibodies are

Select one of the following:

  • pure population of immunoglobulins with same structure ant antigen specifity

  • albumins that are coded from other group of genes

  • mixed population of immunoglobulins with same structure, but different antigen specifity

  • substrate causing expression of immunoglobulins from other class in B-cells

Explanation

Question 4 of 58

1

Which immunological method is not proper for detecting of specific IgE

Select one of the following:

  • Immuno-enzyme(ELİSA, immuno-blot technique)

  • Classical ones(agglutination, precuipitation)

  • Floucytometry

  • Chemilluminescence

Explanation

Question 5 of 58

1

Low levels of IgA are found in case of

Select one of the following:

  • allergic reaction

  • chronic granulamatosis disease

  • selective IgA deficit

  • macro-globulinemia

Explanation

Question 6 of 58

1

Auto immune disease due to antibodies could be a result of (point the wrong answer)

Select one of the following:

  • forming of antigen-antibody complexes

  • antibodies that blockade cell receptor

  • antibody-depended cell-mediated cytotocicitty(ADCC)

  • cell-mediated reaction

Explanation

Question 7 of 58

1

The name of resident macrophages in liver is

Select one of the following:

  • ostephages

  • lagerhance cells

  • kupfer cells

  • microglial

Explanation

Question 8 of 58

1

EBV can cause

Select one or more of the following:

  • Hepatoma

  • Nasopharyngeal carcinoma

  • Burkit lymphoma

  • Adenocaqrcinoma pulmonis

Explanation

Question 9 of 58

1

Which of the following indicators is the most important in case of detecting of immune status in AIDS

Select one of the following:

  • NBT test

  • Anti-DNA antibodies

  • CD4/CD8 index

  • The bence-jones protein

Explanation

Question 10 of 58

1

System lupus erythematosus

Select one of the following:

  • is caused by mutations in ds-DNA

  • is revealed with many symptoms and affects many organs

  • is an example of T-cell mediated disease

  • is a result of generating of immune complexes

Explanation

Question 11 of 58

1

The opsonisation is a process of

Select one or more of the following:

  • Ingestion and destruction of an antigen from phagocyte

  • Of covering of antigen with antibodies in purpose to ease phagocytosis

  • Of covering of antigen with complement in purpose to ease phagoytosis

  • Obtaining of monoclonal antibodies

Explanation

Question 12 of 58

1

Select from the dropdown lists to complete the text.

Connect with arrows allergic diseases with relevant types allergic reactions:
Type ( 3, 1, 2, 4 ) - serum-disease
Type ( 4, 1, 2, 3 ) - contact dermatitis
Type ( 1, 2, 3, 4 ) - anaphylaxis
Type ( 2, 1, 3, 4 )- hemolytic disease of newborn

Explanation

Question 13 of 58

1

The mature B-lymphocytes expresses onto their surface

Select one of the following:

  • IgM and IgD

  • IgM and IgA

  • IgD and IgE

  • IgG and IgD

Explanation

Question 14 of 58

1

The lymphocyte infiltration of thyroidea is typical for

Select one of the following:

  • The hashimoto thyroitidis

  • Euthyroid struma

  • Hemolytic anemia

  • Tuberculosis

Explanation

Question 15 of 58

1

The electrophoresis is

Select one of the following:

  • radial immunodiffusion in gel

  • separation of molecules in electric field

  • complement fixation reaction

  • electroimmunodiffusion

Explanation

Question 16 of 58

1

I type allergic reactions are

Select one of the following:

  • Immunocomplex

  • Cytotoxic

  • IgE mediated

  • Cell mediated

Explanation

Question 17 of 58

1

Select from the dropdown lists to complete the text.

Connect with arrows autoimmune diseases from the left side with relevant characteristics from the right side: wide with relevant characteristics
a. Multiple sclerosis ( 6, 1, 2, 3, 4, 5 )
b. SLE ( 4, 1, 2, 3, 5, 6 )
c. Myasthenia gravis ( 5, 1, 2, 3, 4, 6 )
d. Pernicious anemia ( 1, 2, 3, 4, 5, 6 )
e. Hashimoto thyoiditis ( 2, 1, 3, 4, 5, 6 )
f. Hemolytic anemia ( 3, 1, 2, 4, 5, 6 )

1. autoantibodies against parietal cells of stomach ans intrinsic factor and as a result of this doesn't absorb Vitamin B12
2. autoantibodies against thyroglobuline and thyroid peroxidase
3. antibodies against epitopes of red blood cells
4. antibodies against nucleus antigens
5. antibodies against acetylcholine
6. antibodies against morbidly antigens in liquor and serum, depressed reactions of delayed type hypersensitivity against measles antigens

Explanation

Question 18 of 58

1

The monoclonal antibodies, connected with diphtheria toxin could be used for

Select one of the following:

  • tumour diagnosis

  • immunostimulation

  • immunosupperession

  • immunotherapy of tumors

Explanation

Question 19 of 58

1

The defensins are

Select one of the following:

  • growth factors

  • antimicrobial peptides in granules of neutrophils

  • cytokines-mediators for immune response

Explanation

Question 20 of 58

1

What is the mechanism of III type allergic reactions

Select one of the following:

  • anaphylaxis

  • complement-mediated cytolsis

  • immune complexes

  • infectious immunity

Explanation

Question 21 of 58

1

Which of the following tumour markers are connected with melanoma maligna?

Select one or more of the following:

  • CA-15-3

  • gp 120

  • S100B

  • MART-1Melan A

Explanation

Question 22 of 58

1

Immuno-scintigraphy uses monoclonal antibodies against tumour antigen connected with

Select one of the following:

  • FITC

  • Rhodamine

  • Iodine 131, technetium

  • Enzyme

Explanation

Question 23 of 58

1

INF-γ is produced by

Select one of the following:

  • Activated T lymphocytes

  • Fibroblasts

  • B-lymphocytes

  • Leucocytes

Explanation

Question 24 of 58

1

What kind of auto-antibodies we find in patients with insulin-depended sugar diabetes?

Select one of the following:

  • Nucleus

  • Thyroid microsomes

  • IgG molecules

  • Island cells of pancreas

Explanation

Question 25 of 58

1

Rejection of a transplantant due to pre-forming antibodies in recipient is defined as

Select one of the following:

  • Hyper acute rejection

  • Accelerated

  • Acute

  • Chronic

Explanation

Question 26 of 58

1

What of the following possesses the most expressed oncogenic potential

Select one of the following:

  • Influenza virus type A

  • Ebola virus

  • EBV

  • Polioviruses 1,2 ,3

  • HPV

Explanation

Question 27 of 58

1

Is the following correct?
Active immunity is a nospecific and is an ancient form of defense and lower degree of effectiveness?

Select one of the following:

  • True
  • False

Explanation

Question 28 of 58

1

Type IV allergic reactions are realized by means of

Select one of the following:

  • anaphylaxis

  • complement-mediated cytolysis

  • immune reactions

  • infectious immunity

Explanation

Question 29 of 58

1

True hypersensitivity reactions start usually after

Select one of the following:

  • 15-30 minutes

  • 48 hours

Explanation

Question 30 of 58

1

Which of the following characteristics does not belong to the Burkit lymphoma?

Select one of the following:

  • T-cell neoplasma

  • Is a non-hodgkin lymphoma

  • Has a connections with EBV

  • Is a B-cell lymphoma

Explanation

Question 31 of 58

1

Antigen presenting cells are

Select one or more of the following:

  • Dendrite cells and macrophages

  • T-lymphocytes

  • B-lymphocytes

  • Polymorphy-nuclear cells

Explanation

Question 32 of 58

1

Fill the blank spaces to complete the text.

We could use the mantoux test in diagnosis of (point two diseases)
a-
b-

Explanation

Question 33 of 58

1

Which of the following factors belong to the innate immunity?

Select one or more of the following:

  • Phagocytosis

  • T-lymphocytes

  • Complement, mucin, a-and b inferferons

  • Antibodies

  • Skin, mucus, normal flora

  • B-lymphocytes

Explanation

Question 34 of 58

1

What we could use as a subsrrate for detection of antinuclear antibodies throguh IFA?

Select one or more of the following:

  • rat liver

  • rat kidney

  • rat stomach

  • hep2 cell line

Explanation

Question 35 of 58

1

Which of the pointed immunological parameters is most important for detection of multiple myleoma?

Select one of the following:

  • NBT test

  • Anti-DNA antibodies

  • CD4/CD8 index

  • The Bence-jones protein

Explanation

Question 36 of 58

1

The most popular techniques for detection of antinuclear antibodies are

Select one or more of the following:

  • Agglutination

  • Indirect immunofluorescence

  • Neutralization test

  • The complement fixation test

  • ELISA

  • Direct immunofluorescence

Explanation

Question 37 of 58

1

CD3 molecule is a marker for

Select one of the following:

  • NK cells

  • Macrophages

  • Immunocompetent T lymphocytes

  • Mature B-lymphocytes

Explanation

Question 38 of 58

1

The accelerated reaction for rejection of transplantant is revealed

Select one of the following:

  • Intra-operative or immediately after operation

  • 24-to 72 hours after transplantation

  • Till the third month

  • 3 month after the transplantation

Explanation

Question 39 of 58

1

which of the following immunological indexes ids the most important for patients with chronic granulomatous disease?

Select one of the following:

  • NBT test

  • Anti DNA antibodies

  • CD4/CD8 index

  • The Bence-jones protein

Explanation

Question 40 of 58

1

CEA is increased in case of

Select one or more of the following:

  • nasopharyngeal carcinoma

  • the Burkit lymphoma

  • gatro-intestinal tumors

  • smokers

Explanation

Question 41 of 58

1

Which of the following is connected with damage of humoral immunity?

Select one of the following:

  • Di-George sydrome

  • Agamaglobulinemia of Bruton

  • Chronic candidosis of skin and mucus

  • Angioedema hereditaria

Explanation

Question 42 of 58

1

How many are complement activating ways?

Select one of the following:

  • one

  • three

  • two

  • four

Explanation

Question 43 of 58

1

Fill the blank spaces to complete the text.

The complement activation occurs via three pathways which are:
1. pathway
2. pathway
3. pathway

Explanation

Question 44 of 58

1

The “respiratory burst" is related to

Select one of the following:

  • Humoral immunity

  • Cellular immunity

  • Phagocytosis

  • NK-cells function

Explanation

Question 45 of 58

1

The immune competence of T-lymphocytes is acquired in

Select one or more of the following:

  • Thyroidea

  • Bone marrow

  • Thymus

  • MALT

Explanation

Question 46 of 58

1

What expresses the CD8 molecule?

Select one of the following:

  • Macrophages

  • Antigen presenting cells

  • Cytotoxic T-lymphocytes

  • T- suppressors

Explanation

Question 47 of 58

1

What is human cell receptor for human immunodeficiency virus (HIV)?

Select one of the following:

  • CD3 molecule

  • CD8 molecule

  • CD4 molecule

  • CD19 molecule

Explanation

Question 48 of 58

1

Point the WRONG answer:
Gamma interteron is produced by:

Select one of the following:

  • Non-activated macrophages and mastocytes

  • Leucocytes and Fibroblasts

  • Activated macrophages and NK cell

  • Lymphocytes

Explanation

Question 49 of 58

1

The determination of functional activity of the complement might be done by

Select one of the following:

  • Immune histochemical methods

  • Reaction neutratisation

  • CH50 test

  • Micro haemagglutination

Explanation

Question 50 of 58

1

CD4 molecule is situated on the surface of the

Select one of the following:

  • Monocytes

  • T-helpers

  • Cytotoxic T-lymphocytes

  • Plasmocytes

Explanation

Question 51 of 58

1

The presence of the antigen together with the MHC-II class molecules is realized by

Select one or more of the following:

  • Dendrite cells and macrophages

  • Cytotoxic T-lymphocytes

  • B-lymphocytes

  • Plasmocytes

Explanation

Question 52 of 58

1

A B-cell can synthesise some different antibodies with different species of the antigen

Select one of the following:

  • True
  • False

Explanation

Question 53 of 58

1

After the antigen stimulus the mature B-lymphocytes are transformed into

Select one of the following:

  • cytotoxic cell

  • immunocompetent cell

  • plasmocyte

Explanation

Question 54 of 58

1

What tests are for evaluation of the phagocytic activity?

Select one of the following:

  • Flow cytometry of detection of oxidative burst

  • Serum levels of immunoglobulins

  • CD4/CD8 index

  • NBT test

Explanation

Question 55 of 58

1

Paraproteinemias are detected in

Select one or more of the following:

  • Multiple myeloma

  • Reiter's Syndrome

  • Waldenstrom macroglobulinemia

  • Chronic lymphoid leukemia

  • SLE

Explanation

Question 56 of 58

1

Last cells, incapable to divide are

Select one of the following:

  • Plasmocytes

  • Neutrophils

  • T-lymphocytes

  • B-Iymphocytes

Explanation

Question 57 of 58

1

What do the mature B-lymphocytes express on their surface?

Select one of the following:

  • lgM and IgD

  • IgD ant IgE

  • IgM and IgA

  • IgG and IgD

Explanation

Question 58 of 58

1

How do CD8 eliminate their targets?

Select one or more of the following:

  • after recognition of antigen, connected with MCH-I class molecule

  • after recognition of antigen connected with MCH-II class molecule

  • via activation of an alternative way of complement

  • due releasing of interferon

Explanation

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