Emily Doyle
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Pathophysiology: The Biologic Basis for Disease in Adults and Children 8th Edition

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Emily Doyle
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Chapter 40: Alterations of Renal and Urinary Tract Function in Children

Question 1 of 16

1

The functional kidney is associated with which embryonic organ?

Select one of the following:

  • Metanephros

  • Mesonephros

  • Pronephros

  • Endonephros

Explanation

Question 2 of 16

1

When does urine formation and excretion begin?

Select one of the following:

  • At birth

  • By 3 months’ gestation

  • By 6 months’ gestation

  • By 8 months’ gestation

Explanation

Question 3 of 16

1

Compared with an adult, an infant has a greater content of extracellular fluid, as well as a
greater rate of fluid exchange. What effect does this have on the fluid balance of a child
compared with that of an adult?

Select one of the following:

  • Edema development is less of a problem.

  • Overhydration is not difficult to manage.

  • Daily fluid requirements are greater.

  • The control of dehydration is more difficult.

Explanation

Question 4 of 16

1

What term is used to identify the condition that exists when the urethral meatus is located on
the undersurface of the penis?

Select one of the following:

  • Hypospadias

  • Epispadias

  • Hyperspadias

  • Chordee

Explanation

Question 5 of 16

1

What initiates inflammation in acute poststreptococcal glomerulonephritis?

Select one of the following:

  • Lysosomal enzymes

  • Endotoxins from Streptococcus

  • Immune complexes

  • Immunoglobulin E (IgE)–mediated response

Explanation

Question 6 of 16

1

Acute glomerulonephritis (AGN) may be accompanied by a positive throat or skin culture for
which bacteria?

Select one of the following:

  • Staphylococcus aureus

  • Streptococcus

  • Pseudomonas aeruginosa

  • Haemophilus

Explanation

Question 7 of 16

1

A child with acute poststreptococcal glomerulonephritis is voiding smoky, brown-colored
urine and asks the healthcare professional to explain what causes it. What explanation by the
professional is best?

Select one of the following:

  • Presence of red blood cells

  • Presence of urobilinogen

  • Slough from the collecting tubules

  • Protein in the urine

Explanation

Question 8 of 16

1

In immunoglobulin G (IgG) nephropathies such as glomerulonephritis, IgG is deposited in
which location?

Select one of the following:

  • Juxtamedullary nephrons

  • Glomerulus basement membranes

  • Mesangium of the glomerular capillaries

  • Parietal epithelium

Explanation

Question 9 of 16

1

What is the pathophysiologic process responsible for the autoimmune disorder of
hemolytic-uremic syndrome (HUS)?

Select one of the following:

  • Immunoglobulin A (IgA) coats erythrocytes that are destroyed by the spleen, and remnants are excreted through the kidneys.

  • Verotoxin from Escherichia coli is absorbed from the intestines and damages
    erythrocytes and endothelial cells.

  • Endotoxins from E. coli block the erythropoietin produced by the kidneys, which reduces the number of erythrocytes produced by the bone marrow.

  • Failure of the nephron to filter urea increases the blood urea nitrogen, which binds to erythrocytes that are subsequently destroyed by the spleen.

Explanation

Question 10 of 16

1

What is the first indication of nephrotic syndrome in children?

Select one of the following:

  • Periorbital edema

  • Scrotal or labial edema

  • Frothy urine

  • Ascites

Explanation

Question 11 of 16

1

Bacteria gain access to the female urinary tract by which means?

Select one of the following:

  • Systemic blood that is filtered through the kidney

  • Bacteria traveling from the lymph adjacent to the bladder and kidneys

  • Bacteria ascending the urethra into the bladder

  • Colonization of the bladder when urine is static

Explanation

Question 12 of 16

1

What causes vesicoureteral reflux to occur in children?

Select one of the following:

  • Children do not ask for help in urinating in a timely manner, and urine is forced up into the ureters.

  • The submucosal segment of a child’s ureter is short, making the antireflux
    mechanism inefficient.

  • The trigone lying between the opening to the ureters and the urethra is
    underdeveloped in children.

  • As the bladder fills in infants and children, it pulls the smooth lining of the
    transitional epithelium away from the ureters, making the reflux valves ineffective.

Explanation

Question 13 of 16

1

What is the mechanism for developing Wilms tumor?

Select one of the following:

  • It involves tumor-suppressor genes located on chromosome 11.

  • Development involves an autosomal dominant inheritance pattern.

  • Wilms tumor is an autoimmune disorder

  • The development of a Wilms tumor is a congenital anomaly.

Explanation

Question 14 of 16

1

Which anomaly is often associated with Wilms tumor?

Select one of the following:

  • Renal anaplasia

  • Aniridia

  • Anemia

  • Hypothyroidism

Explanation

Question 15 of 16

1

A healthcare professional has taught a parent group about the causes of enuresis. What
statement by a parent indicates the professional needs to give more information?

Select one of the following:

  • A maturational lag may cause enuresis

  • Enuresis may be related to increased light sleep.

  • Obstructive sleep apnea may be a symptom of enuresis.

  • Elevated nocturnal levels of vasopressin may cause enuresis.

Explanation

Question 16 of 16

1

When does an individual have their full complement of renal nephrons?

Select one of the following:

  • At birth

  • At 6 months of age

  • At puberty

  • Between the ages 18 and 21 years

Explanation