Subdivisions of the nervous system

Pre- and post- junctional events at a cholinergic synapse summary

1. Synthesis and 2. storage of Ach

Drugs that effect synthesis and storage of Ach

3. Release of Ach and 4. Ach/receptor interaction

Structure-activity relationships

Muscarinic receptors

Clinical uses of muscarinic agonists

Antagonists that block Ach receptors:
clinical uses

Side effects of muscarinic antagonists

Nicotine receptors

Nicotinic agonists and antagonists

5. Inactivation (of released Ach)

Anticholinestherases; block AchE activity by different mechanisms

Therapeutic uses of anticholinestherases

Side effects of anticholinestherases that act at the ganglia in the ANS

Side effects of anticholinestherases at the neuromuscular junction

Side effects of anticholinestherases at the CNS

Side effects of the anticholinestherases organophosphates