BMS04-1038- Control of gene expression 1

Flashcards by Evian Chai, created more than 1 year ago

The reasons for regulating gene expression. The different levels of gene regulation in eukaryotes. Regulation of RNA expression during transcription initiation. cis sequences and trans acting factors. Promoter, TATA box, transcription factors. How general transcription factors and RNA Pol II bring about constitutive gene expression. Regulation by hormones. Examples of regulation of RNA expression during poly-adenylation and splicing. What happens when gene regulation is dys-regulated.

	Created by Evian Chai about 4 years ago

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When is gene expression regulated?

What is the major point of gene expression regulation?

What are transacting molecules?
What do transacting molecules bind to?

What type of molecule is General Transcription Factors that initiate transcription?

What are regulatory sequences?
Where are they located?
Why are they considered "cis"?
What is an example?

What is the TATA Box, where is it, and what does it do?

Where is the promoter found in relation to the coding region? What occurs at this region?

What do general transcription factors do?

What do sequence specific DNA binding TFs do? Where do they bind?

What are two ways hormones can influence gene expression?

How can gene expression be regulated during the polyadenylation of RNA?

How does differential/alternative splicing of RNA allow for gene regulation?

How does fibronectin differ in the liver and fibroblasts?

Why does gene expression need to be controlled?