Trey W
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Medicine Quiz on Cellular Adaptations & Necrosis, created by Trey W on 18/07/2020.

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Cellular Adaptations & Necrosis

Question 1 of 22

1

Which of the following is not a pattern of cell death in tissues?

Select one of the following:

  • fibrinoid necrosis

  • fat necrosis

  • coagulative necrosis

  • contracture necrosis

Explanation

Question 2 of 22

1

Compare acute cell injury with cellular adaptations.

Select one or more of the following:

  • Cellular adaptations develop over a brief period of time and are reversible

  • Acute cell injury can be manifested as reversible cell swelling

  • Acute cell injury can be manifested as irreversible necrosis

Explanation

Question 3 of 22

1

What is lipofuscin?

Select one of the following:

  • Blue-pigmented cytoplasmic inclusions in stressed cells

  • A lipid-containing residual body of autophagy

  • An irreversible "wear and tear" pigment

  • A product of cells undergoing decreased cell turnover

Explanation

Question 4 of 22

1

Metatstatic calcification is due to precipitation of calcium at sites of cell/tissue injury

Select one of the following:

  • True
  • False

Explanation

Question 5 of 22

1

Which of the following mechanisms explains the pathogenesis of alcohol-induced fatty liver?

Select one or more of the following:

  • Increased delivery of free fatty acids

  • Increased lipogenesis

  • Decreased apoprotein synthesis for triglyceride export

  • Increased utilization of triglycerides and oxidation of fatty acids

Explanation

Question 6 of 22

1

Metaplasia can be characterized by which of the following?

Select one of the following:

  • One adult cell type being replaced by another through chronic injury

  • Irreversible change in cells/tissue

  • Decreased risk of malignancy/neoplasia

  • Increase in cell number

Explanation

Question 7 of 22

1

Which is an example of physiologic apoptosis?

Select one of the following:

  • Formation of the esophageal lumen

  • Syndactyly

  • Muscular dystrophy

  • Chronic lymphocytic leukemia

Explanation

Question 8 of 22

1

Apoptosis can result from endogenous OR exogenous causes

Select one of the following:

  • True
  • False

Explanation

Question 9 of 22

1

In a Masson Trichrome stain

Select one of the following:

  • Nucleic acids stain dark blue

  • Connective tissue stains blue

  • Proteins stain light purple

Explanation

Question 10 of 22

1

Which of the following would you expect to see in necrosis?

Select one of the following:

  • A rounded up, fragmented cell morphology

  • Phagocytosis by neutrophils

  • Phagocytosis by macrophages and nonprofessional macrophages

  • Functionally intact cell membrane

Explanation

Question 11 of 22

1

You are examining the tissue of a patient who had a subarachnoid hemorrhage. When looking at the brain tissue microscopically, what would you expect to observe in the area of hemorrhage?

Select one of the following:

  • Pneumonoultramicroscopicsilicovolcanoconiosis

  • Hemosiderosis

  • Steatosis

  • Anthracosis

Explanation

Question 12 of 22

1

At what point in cell injury would you expect to observe hydropic change of the cell?

Select one of the following:

  • < 10 minutes

  • 10-15 minutes

  • 15-60 minutes

  • 4-8 hours

Explanation

Question 13 of 22

1

You know that irreversible cell injury is often characterized by nuclear changes. Which of the nuclear changes describes pyknosis?

Select one of the following:

  • Fragmentation of the nucleus into dense basophilic fragments ("nuclear debris")

  • Dissolution of nuclear fragments

  • Condensation of chromatin

  • Dilation of the endoplasmic reticulum

Explanation

Question 14 of 22

1

In coagulative necrosis, the shapes of cells and tissues change dramatically, but the nuclei/organelles are intact.

Select one of the following:

  • True
  • False

Explanation

Question 15 of 22

1

Where would you expect to see liquefactive necrosis most often?

Select one or more of the following:

  • Brain

  • Lungs

  • Abscesses

  • GI tract

Explanation

Question 16 of 22

1

Your patient's cells and tissues demonstrate obvious enzymatic necrosis. You immediately know the condition that (likely) caused this is:

Select one of the following:

  • COVID

  • Acute pancreatitis

  • Myocardial infarction

  • Hypercalcemia

Explanation

Question 17 of 22

1

What is the most common cause of caseous necrosis?

Select one of the following:

  • Dry gangrene

  • Wet gangrene

  • Mycobacteria tuberculosis

  • Eating too much cottage cheese

Explanation

Question 18 of 22

1

Fibrinoid necrosis is caused by injury to vessel walls that causes leakage of protein and fibrin from the circulation that becomes entrapped. Which vascular injury might cause this type of necrosis?

Select one or more of the following:

  • Immune-complex associated vasculitis

  • Accelerated HTN

  • HTN that has slowly developed over 20 years

  • Excessive scarring

Explanation

Question 19 of 22

1

What is a heterophagosome?

Select one of the following:

  • A secondary lysosome involved in digestion of a cell's own organelles

  • A primary lysosome fused with absorptive vesicles originating from the plasma membrane

  • A small vesicle budding from enzymes on the lateral side of the Golgi apparatus

Explanation

Question 20 of 22

1

In your elective oncology rotation, a patient presents with multiple calcified breast tumors. You know this to be a result of metastatic calcification.

Select one of the following:

  • True
  • False

Explanation

Question 21 of 22

1

Upon histological examination, tissue cells demonstrate what looks like "nuclear dust". This is characteristic of

Select one of the following:

  • karyorrhexis

  • karyolysis

  • karyogram

  • pyknosis

Explanation

Question 22 of 22

1

In response to , columnar epithelial cells of the bronchial epithelium undergo squamous . Smoking-induced metaplasia may lead to bronchial squamous cell .

Drag and drop to complete the text.

    cigarette smoke
    sitting for 12 hours/day
    drinking too much water
    pulmonary HTN
    metaplasia
    hyperplasia
    neoplasia

Explanation

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