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Year 2 (Insulin & Glucagon) Quiz on Glycogen Phosphorylase, created by gina_evans0312 on 23/10/2013.

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Glycogen Phosphorylase

Glycogen Phosphorylase

Question 1 of 20

1

Which form of Glycogen Phosphorylase is relatively inactive?

Select one of the following:

  • Phosphorylase A

  • Phosphorylase B

Explanation

Question 2 of 20

1

In phosphorylase B, where is the N terminus?

Select one of the following:

  • Floating free in the cytoplasm

  • Attached to the protein body

  • Unattached from protein

Explanation

Question 3 of 20

1

Which of the forms of glyocgen phosphorylase is most effected by cellular AMP/ATP levels?

Select one of the following:

  • Phosphorylase A

  • Phosphorylase B

Explanation

Question 4 of 20

1

Which of the following phosphorylates Glycogen Phosphorylase?

Select one of the following:

  • Phosphorylase B Kinase

  • Phosphorylase A Kinase

  • Phosphorylase Kinase

Explanation

Question 5 of 20

1

What protein causes the dephosphorylation of phosphorylase?

Select one of the following:

  • Protein phosphatase

  • Protein phosphorylase

  • Prokein Kinase P

Explanation

Question 6 of 20

1

What is needed for the reaction of Phosphorylase B --> A to reverse itself?

Select one of the following:

  • Water (and a lack of inhibiting AMP)

  • Water (and a lack of inhibiting ATP)

  • Water (and a lack of inhibiting GMP)

Explanation

Question 7 of 20

1

What is different about Phosphorylase A to B?

Select one of the following:

  • Ser14 has been phosphorylated

  • Tyr14 has been phosphorylated

  • Thr14 has been phosphorylated

Explanation

Question 8 of 20

1

What difference does phosphorylating Glycogen phosphorylase make?

Select one of the following:

  • Makes the relaxed form much more likely

  • Makes the taut form much more likely

  • Deactivates it entirely

Explanation

Question 9 of 20

1

How does phosphorylase B Kinase connect Glycogen Phosphorylase levels to the level of stimulation?

Select one of the following:

  • It is activated by Ca2+- when the muscle is stimulated, glucose is needed and so glycogen is broken down

  • It is deactivated by Ca2+- when the muscle is stimulated, glucose is not needed and so glycogen isn't broken down

Explanation

Question 10 of 20

1

What part of Phosphorylase B Kinase binds to Calcium?

Select one of the following:

  • Calmodulin

  • Calsequestrin

  • Troponin C

Explanation

Question 11 of 20

1

Which parts of phosphorylase B kinase are regulatory?

Select one of the following:

  • Alpha and beta

  • Alpha and gamma

  • Gamma and beta

Explanation

Question 12 of 20

1

Which part of phosphorylase B kinase is catalytic?

Select one of the following:

  • Gamma

  • Delta

  • Beta

Explanation

Question 13 of 20

1

In phosphorylase B kinase's Ca2+ binding sites, what are the affinities?

Select one of the following:

  • 2 high
    2 low

  • 4 high

  • 4 low

Explanation

Question 14 of 20

1

What protein causes the phosphorylation of Phosphorylase B Kinase?

Select one of the following:

  • cAMP dependent Protein Kinase

  • Adenylate Cyclase

  • Glycogen Phosphorylase

Explanation

Question 15 of 20

1

What is another name of cAMP dependent protein kinase?

Select one of the following:

  • Protein Kinase A

  • Protein Kinase B

  • Protein Kinase C

Explanation

Question 16 of 20

1

What is the role of inhibitor one?

Select one of the following:

  • To bind to protein phosphatase, activating it

  • To bind to protein phosphatase, inhibiting it

  • To bind to protein kinase A, activating it

Explanation

Question 17 of 20

1

What is contained in the N terminus domain of Glycogen Phosphorylase?

Select one of the following:

  • The catalytic site

  • The allosteric effector site

  • The regulatory subunit

Explanation

Question 18 of 20

1

How does glycogen get from it's binding domain to the catalytic site?

Select one of the following:

  • A hydrophobic tunnel

  • A hydrophillic tunnel

  • A lipophobic tunnel

Explanation

Question 19 of 20

1

Why is glycogen phosphorylase's site in a deep groove?

Select one of the following:

  • To prevent AMP from entering

  • To prevent ATP from entering

  • To prevent water from entering

Explanation

Question 20 of 20

1

What happens if water enters the active site?

Select one of the following:

  • Nothing

  • The enzyme is deactivated

  • Hydrolysis occurs instead of phosphorolysis

Explanation

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