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Questions on autoimmunity

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Autoimmunity

Autoimmunity

Question 1 of 31

1

Autoimmunity is characterized by all the following except

Select one of the following:

  • It is when your immune system is acting against you

  • These are acute disease with evidence of active infection

  • It is due to failure of tolerance (both central and peripheral)

  • none of the above

Explanation

Question 2 of 31

1

Negative selection in the bone marrow and thymus means removal of self reactive antigen during development

Select one of the following:

  • True
  • False

Explanation

Question 3 of 31

1

All of the following are a feature of peripheral tolerance except?

Select one of the following:

  • No lymphocyte access to some tissues - ignorance

  • Induction of anergy in autoreactive B and T cells

  • Suppression of autoimmune responses by regulatory T cells - Foxp3

  • Expression of tissue specific protein in thymus - Aire

Explanation

Question 4 of 31

1

Central deletion or inactivation of newly formed lymphocytes is the first checkpoint of self-tolerance

Select one of the following:

  • True
  • False

Explanation

Question 5 of 31

1

Autoimmune Regulator (AIRE) is essential for acquisition of central T cell tolerance

Select one of the following:

  • True
  • False

Explanation

Question 6 of 31

1

APECED syndrome is due to inactivating mutation of Foxp3

Select one of the following:

  • True
  • False

Explanation

Question 7 of 31

1

all of the following are true about IPEX syndrome except

Select one of the following:

  • Autosomal dominant

  • Inactivating mutation or deletion of Foxp3

  • Polyendrocrinopathy

  • T reg absent or non-function

Explanation

Question 8 of 31

1

All of the following about B cell tolerance are true except?

Select one of the following:

  • Deletion of self reactive IgM B cells in bone marrow is 100% efficient

  • We all have autoreactive B cells

  • Under normal circumstances a parallel autoreactive T cell will be absent and or a T reg will be present, so you are unlikely to have T cell help for autoreactive B cells

  • The presence of autoreative B cell becomes obvious as one ages and loses T cell mediated regulation

Explanation

Question 9 of 31

1

All of the following are true about auto immune diseases except

Select one of the following:

  • MHC molecules which are able to efficiently present self antigen

  • A failure to delete or functional inactivate self reactive lymphocytes - Breakdown of immunological tolerance

  • Additional environmental and or genetic factors - Viral or bacterial infections, susceptibility genes, hormonal influences, toxins and tissue damage

  • None of the above

Explanation

Question 10 of 31

1

Ankylosing spondylitis is associated with HLA B27

Select one of the following:

  • True
  • False

Explanation

Question 11 of 31

1

People heterozygous for DQ2 and DQ8 are most susceptible to Type I Diabetes

Select one of the following:

  • True
  • False

Explanation

Question 12 of 31

1

Sympathetic ophthalmia is an example of unveiling of antigens previously not accessible to the immune systems

Select one of the following:

  • True
  • False

Explanation

Question 13 of 31

1

Molecular mimicry - an antibody of T cell response induced against a pathogen cross - reacts with a self antigen - ex Rheumatic fever - true of false

Select one of the following:

  • True
  • False

Explanation

Question 14 of 31

1

An example for intermolecular epitope spreading is Pemphigus

Select one of the following:

  • True
  • False

Explanation

Question 15 of 31

1

Over-expression of anti-inflammatory molecules and Underexpression of Pro-inflammatory molecules - is the aberrant expression seen in autoimmune diseases

Select one of the following:

  • True
  • False

Explanation

Question 16 of 31

1

Autoimmune diseases are more common in males

Select one of the following:

  • True
  • False

Explanation

Question 17 of 31

1

Smoking increases the autoimmune reaction by citrullinating the proteins

Select one of the following:

  • True
  • False

Explanation

Question 18 of 31

1

Aging increases autoimmunity due to immune senescence

Select one of the following:

  • True
  • False

Explanation

Question 19 of 31

1

All of the following about autoimmune hemolytic anemia are true except?

Select one of the following:

  • HSR III

  • Produce autoantibodies against antigens on RBCs - IgG and IgM

  • It could be drug induced ex penicillin

  • Diagnosis by Direct Coombs test

Explanation

Question 20 of 31

1

Goodpasture syndrome autoantibodies against alpha3 chain of type IV collagen in glomerular basement membrane and alveolar basement membrane

Select one of the following:

  • True
  • False

Explanation

Question 21 of 31

1

A patient presents with multiple blisters on his back and both arms. You lightly rub his skin and another blister forms because you disrupted the connection between 200 desmosomes. All of the following are true about this disorder except?

Select one of the following:

  • HSR II

  • Autoantibodies against desomogleins

  • intermolecular spreading

  • This condition is Pemphigus vulgaris

Explanation

Question 22 of 31

1

Myasthenia Gravis is due to anti-ACH receptor antibodies and Lambert-Eaton syndrome is due to auto antibodies against voltage gated Calcium channels thereby inhibiting the release of calcium

Select one of the following:

  • True
  • False

Explanation

Question 23 of 31

1

In all II and III HSR Plasmapheresis is not effective

Select one of the following:

  • True
  • False

Explanation

Question 24 of 31

1

All II and III HSR antibodies can cross the placenta and can effect the fetus

Select one of the following:

  • True
  • False

Explanation

Question 25 of 31

1

All of the following are true about IDDM except

Select one of the following:

  • Peptides associated with islet cell autoantigens Glutamic acid decarboxylase 65 (GAD65) are cross reactive with Coxsackie virus proteins

  • HSR III

  • Macrophage activation by TNFalpha and IL-1

  • Beta cell specific Th1 cells make IFNgamma

Explanation

Question 26 of 31

1

All of the following are true about Multiple sclerosis except?

Select one of the following:

  • Destruction of myelin sheath of nerve fibers in brain and spinal cord due to autoreactive T cells - Type IV HSR

  • Areas of demyelination (plaques) seen on MRI

  • Candidate antigens: Myelin basic protein and Myelin Oligodendrocyte glycoprotein

  • completely curable

Explanation

Question 27 of 31

1

All of the following are true about SLE except?

Select one of the following:

  • Most common autoimmune rheumatic disease

  • Intermolecular spreading

  • HSR IV

  • ANA test is a screening test only - anti-dsDNA, anti-snRNP or Sm(smith antigen) are also 100% specific for SLE

  • UV-B exposure and cigarette smoking are the environmental triggers

Explanation

Question 28 of 31

1

All of the following are true about Rheumatoid arthritis except?

Select one of the following:

  • Presence of Rheumatoid factor is diagnostic of Rheumatoid arthritis

  • Infliximab, Adalimumab, Etanercept TNFR-IG all are effective against RA

  • Autoreative CD4 Tb1 cells and Tb17 cells against synovial tissue autoantigen

  • None of the above

Explanation

Question 29 of 31

1

All of the following are true about Sjogren's syndrome except

Select one of the following:

  • Autoimmune destruction of exocrine glands

  • HSR III

  • Shrimer's test - to test tear production, spit test are done

  • none of the above

Explanation

Question 30 of 31

1

All of the following are true about Wegener's Granulomatosis except

Select one of the following:

  • Anti Neutrophil Cytoplasmic antibodies (ANCA)

  • Saddle nose due to destruction of the cartilage

  • cavitary lesions are characteristic on chest xray

  • more common in females

Explanation

Question 31 of 31

1

All of the following are associated with scleroderma except

Select one of the following:

  • Raynaud's syndrome

  • Sclerodactyly

  • Male predominance

Explanation

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