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Structural Basis for Biological Function (Basics) Quiz on Growth Factors, created by gina_evans0312 on 04/11/2013.

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Growth Factors

Growth Factors

Question 1 of 9

1

Epidermal Growth Factors are 53aa long, with an Mr of 40,000

Select one of the following:

  • True

  • False

Explanation

Question 2 of 9

1

What happens when you increase ornithine carboxylase and polyamine concentrations?

Select one of the following:

  • Cell division increases

  • Cell division decreases

Explanation

Question 3 of 9

1

In general effects ( inc glucose/aa transport and inc Na/K ATPase activity) what hormone are growth factors most like?

Select one of the following:

  • Insulin

  • Glucagon

  • Vasopressin

  • NO

Explanation

Question 4 of 9

1

Increase Na+/H+ pump activity causes what?

Select one or more of the following:

  • Alkylysation of the cytoplasm

  • Inc. DNA synthesis/mitosis

  • Inc protein production

Explanation

Question 5 of 9

1

How is tyrosine kinase kept inactive when a ligand is not bound?

Select one of the following:

  • The activation lip hides the active site

  • The active site is phosphorylated and inactive

  • A pseudosubstrate is bound

Explanation

Question 6 of 9

1

What form does inactive tyrosine kinase stay in?

Select one of the following:

  • Monomer

  • Dimer

  • Multimeric group

Explanation

Question 7 of 9

1

What effect does ligand binding have to tyrosine kinase?

Select one or more of the following:

  • Partial activation

  • Dimerisation

  • Monomerisation

  • Full activation

Explanation

Question 8 of 9

1

Once the activation lip is phosphorylated, what happens?

Select one or more of the following:

  • Phosphorylation continues of tyrosine kinase

  • Becomes fully active

  • Becomes partially active

  • Proteins bind to phosphorylated areas

Explanation

Question 9 of 9

1

Which of the following binds to phosphorylated tyrosine kinase?

Select one of the following:

  • GRB2

  • RAs

  • GEF

Explanation

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