Here are some flashcards to assist you in learning material contained in Week1 of this course
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Define what is meant by term pharmacokinetics
Define the term pharmacodynamics
True or False:
Different isomers of the same drug may produce a different magnitude of response at the same receptor type
In the Emax pharmacodynamic model, define what Emax is
How does a drug which is a partial agonist at a receptor differ from a drug which is a full agonist?
What is an antagonist?
Define tolerance to a drug
The acronym ADME is used in pharmacokinetics. What does each letter stand for?
How does serum differ from plasma?
True or False: It is only drug bound to plasma proteins that can pass through biological membranes
True or False:
It is only unbound (free) drug that can interact with receptors
Describe the processes that occur when we swallow a tablet
What is the main organ in the body where metabolism occurs?
True or False:
The properties of a drug can influence the rate and extent of absorption from the gut when administered orally
Which of the following routes of administration do NOT involve an absorption step?
Intravenous
Intramuscular
Oral
rectal
What do we mean by transdermal drug delivery?
What is therapeutic drug monitoring involve?
Therapeutic drug monitoring relies on good correlation between concentration and effect. What factors may lead to poor correlation between concentration and effect?
What is meant when a drug has a "Narrow Therapeutic Index"?
How is a therapeutic range determined?
True or False:
If we measure the plasma drug concentration in a patient and it is above the maximum safe concentration (or maximum tolerated concentration), the patient will always have signs of toxicity
When we administer the same dose to a number of patients, what factors will contribute to the variability we see in achieved plasma drug concentrations?
What makes a drug a good candidate for therapeutic drug monitoring?
List some different assay techniques used in TDM
An assay is only as good as the performance of the assay technique. Discuss how selectivity of assay is important
With assay techniques, it is important to have good accuracy and precision.
What do we mean by accuracy and precision
Why is it important that the correct type of blood collection tube is used when the sample is taken from the patient?
