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Year 2 Quiz on Tumor Suppressors, created by gina_evans0312 on 03/12/2013.

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Tumor Suppressors

Tumor Suppressors

Question 1 of 22

1

What is the role of the Rb Susceptibility gene?

Select one of the following:

  • Nuclear transcription factor

  • Nuclear phosphatases

  • Nuclear phosphorylases

Explanation

Question 2 of 22

1

What protein does Rb bind to?

Select one of the following:

  • E2F

  • FF2

  • EF2

Explanation

Question 3 of 22

1

What is the role of the protein bound to Rb?

Select one of the following:

  • Transcription factor

  • Kinase

  • Phosphatase

Explanation

Question 4 of 22

1

What are the target genes of the Rb bound protein?

Select one of the following:

  • dNTP producing genes

  • Transcription factor producing genes

  • Growth factor producing genes

Explanation

Question 5 of 22

1

How is Rb phosphorylated and deactivated?

Select one of the following:

  • By Cyclin

  • By CDK

  • By a cyclin/CDK dimer

Explanation

Question 6 of 22

1

What protein phosphorylates CDK?

Select one of the following:

  • CAK

  • CAD

  • CAB

Explanation

Question 7 of 22

1

Which forms first during G1?

Select one of the following:

  • CDK/Cyclin D

  • CDK/Cyclin E

Explanation

Question 8 of 22

1

What causes the production of Cyclin/CDK E &D?

Select one of the following:

  • Jun Activity

  • AP1 Activity

  • Myc Activity

Explanation

Question 9 of 22

1

Which is required to activate E2F?

Select one of the following:

  • Cyclin/CDK D

  • Cyclin/CDK E

  • Both

  • Neither

Explanation

Question 10 of 22

1

Name 3 CDK inhibitors

Select one or more of the following:

  • p13

  • p21

  • p12

  • p16

  • p27

  • p19

Explanation

Question 11 of 22

1

Which of the following binds to CDK, & twists its head to block the active site?

Select one of the following:

  • p16

  • p12

  • p19

Explanation

Question 12 of 22

1

Which of the following bind to cdk with cyclin and physically block the active site?

Select one or more of the following:

  • p21

  • p27

  • p19

Explanation

Question 13 of 22

1

How are the CDK inhibitors controlled?

Select one of the following:

  • Phosphorylation & degredation

  • Phosphorylation & activation

Explanation

Question 14 of 22

1

How long is the bp sequence p53 binds to?

Select one of the following:

  • 10 bp

  • 12 bp

  • 15 bp

Explanation

Question 15 of 22

1

Put the following p53 domains in order A- Signalling Domain B- Damaged DNA binding domain C-Oligomerization Domain D- Activation Domain E- DNA binding domain

Select one of the following:

  • D-A-E-C-B

  • D-A-C-E-B

  • A-D-C-E-B

  • B-A-D-E-C

Explanation

Question 16 of 22

1

How does p53 work in its active form?

Select one of the following:

  • As a monomer

  • As a dimer

  • As a tetramer

Explanation

Question 17 of 22

1

What does p53 bind to when active?

Select one of the following:

  • TATA boxes

  • E-boxes

  • Damaged DNA

Explanation

Question 18 of 22

1

What can cause the activation of p53?

Select one or more of the following:

  • Acetylation

  • Phosphorylation

  • Ionising radiation

Explanation

Question 19 of 22

1

What does p53 do if activated in G1?

Select one of the following:

  • Repairs DNA

  • Reverts the cell back to G0

  • Forces cell through mitotic cycle

Explanation

Question 20 of 22

1

What happens if p53 is activated after G1?

Select one of the following:

  • Bax is transcribed- it initiates apoptosis

  • Bax is transcribed- It initiates S phase

  • Bax is transcribed- It inhibits M phase

Explanation

Question 21 of 22

1

Where do mutations causing non-function tend to occur in p53?

Select one of the following:

  • The DNA binding domain

  • The damaged DNA binding domain

  • The signalling domain

Explanation

Question 22 of 22

1

How is p53 removed from the cell?

Select one of the following:

  • MDM2

  • MDM

  • MDM1

Explanation

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