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What is addiction?
Addiction is complex
hedonic value
positive-incentive value
ABC
Drugs with addictive potential
mesocorticolimbic DA-pathway
Stimulant Drugs
Symptoms of acute stimulant use
Stimulants work as dopamine agonists
DA transporters
injecting cocaine is reinforcing
injecting cocaine is reinforcing
speed of drug maximum concentration and half-life
Speed of drug maximum concentration and half-life
tolerance & wtihdrawal mark physical dependence
withdrawal
tolerance
withdrawal
common withdrawal symptoms
drug tolerance lowers a drug's effect
"Upping" the dose is riskly...
Chart of "upping the dose"
"Upping" the dose is risky...
Allostasis: withdrawal & tolerance effects
Shift of allostasis
negative reinforcement
