Intro to virology

Question 1 of 31

1

The outer surface of the capsid mediates with host cells.

Select one of the following:

Naked Virus
Enveloped Virus

Explanation

Question 2 of 31

1

The glycoproteins anchored in the envelope and pointing out mediate contact with the host cells.

Select one of the following:

Naked Virus
Enveloped Virus

Explanation

Question 3 of 31

1

Which type of virus is especially Sensitive to lipid solvents (ex. Chloroform, ether) and also to non-ionic detergents.

Select one of the following:

Naked Viruses
Enveloped Viruses

Explanation

Question 4 of 31

1

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( Naked, Enveloped ) viruses tend to be more stable to environmental changes than ( Naked, Enveloped ) viruses.

Explanation

Question 5 of 31

1

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( Naked, Enveloped ) viruses are usually transmitted via aqueous environment: e.g. various body secretions, blood

Explanation

Question 6 of 31

1

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( Naked, Enveloped ) viruses may be transmitted by many routes: e.g. secretions/blood, oral-fecal, skin contact

Explanation

Question 7 of 31

1

What viral structure is defined as a lipid bilayer derived from host cell membranes during the process of virus maturation.

Select one of the following:

Virion
Capsid
Envelope
Nucleocapsid

Explanation

Question 8 of 31

1

Which viral structure is defined as a protein shell that surrounds and protects the viral genome?

Select one of the following:

Virion
Capsomer
Nucleocapsid
Envelope
Cell wall
Capsid

Explanation

Question 9 of 31

1

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( Icosahedral, Helical ) structures approximate spheres.

Explanation

Question 10 of 31

1

Icosahedral structures can have which of the following axis/axes of symmetry? (Select all that apply)

Select one or more of the following:

none. Icosahedral is not symmetrical.
two-fold
three-fold
four-fold
five-fold

Explanation

Question 11 of 31

1

Helical structures can have which of the following axis/axes of symmetry? (Select all that apply)

Select one or more of the following:

None. Helical structures are not symmetrical.
two-fold
three-fold
four-fold
five-fold

Explanation

Question 12 of 31

1

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The Corona family of viruses is classified as
- ( Enveloped, Naked )
-( RNA, DNA ) virus
-with ( helical, icosahedral ) symmetry of the capsid. -It has a ( positive, negative ), ( single-stranded, double stranded ), ( non-segmented, 10-18 segment, 3 Segment, 8 Segment, 2 Segment, 2 copies ) genome.
-It is virion polymerase ( negative, positive ).
-It's genome size is ( 16-21, 22-27, 8, 7.2-8.4, 10, 12, 3.5-9, 12.7, 13-16, 13.5-21, 13.6, 16-20, 10-14 ) kb.

Explanation

Question 13 of 31

1

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The Reo family of viruses is classified as
-( Naked, Enveloped )
-( RNA, DNA ) virus
-with ( Icosahedral, Helical ) symmetry of the capsid.
-It has a ( double-stranded, single-stranded ), ( 10-18 segment, non-segmented, 2 copies, 3 segment, 8 segment, 2 segment ) genome.
-It is virion polymerase ( positive., negative. )
-It's genome size is ( 22-27, 8, 7.2-8.4, 10, 12, 3.5-9, 16-21, 12.7, 13-16, 16-20, 10-14 ) total in kb.

Explanation

Question 14 of 31

1

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The Calici family of viruses is classified as a:
-( Naked, Enveloped )
-( RNA, DNA ) virus
-with ( Icosahedral, Helical ) symmetry of the capsid.
-It has a ( (+) single-stranded, non-segmented, double-stranded, 10-18 segment, (+) single-stranded, 2 copies, (-) single-stranded, non-segmented, (-) single stranded, 3 segment, (-) single stranded, 8 segment, (-) single-stranded, 2 segment ) genome.
-It is virion polymerase ( negative, positive ).
-It's genome size is ( 8, 22-27, 7.2-8.4, 10, 12, 3.5-9, 16-21, 12.7, 13-16, 13.5-21, 13.6, 16-20, 10-14 ) total in kb.

Explanation

Question 15 of 31

1

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The Picorna family of viruses is classified as a:
-( Naked RNA, Naked DNA, Enveloped RNA, Enveloped DNA ) virus with ( Icosahedral, Helical ) symmetry of the capsid.
-It has a ( (+) single-stranded, non-segmented, double-stranded, 10-18 segment, (+) single-stranded, 2 copies, (-) single-stranded, non-segmented, (-) single-stranded, 3 segment, (-) single stranded, 8 segment, (-) single stranded, 2 segment ) genome.
-It is virion polymerase ( negative, positive ).
-It's genome size is ( 7.2-8.4, 22-27, 3.5-9, 13.5-21, 8 ) total in kb.

Explanation

Question 16 of 31

1

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The Flavi family of viruses is classified as a(n):
-( Enveloped RNA, Enveloped DNA, Naked DNA, Naked RNA ) virus with ( Icosahedral, Helical ) symmetry of the capsid.
-It has a ( (+) ss continuous, (-) ss continuous, (-) ss, 3 segment, (-) ss, 8 segment, (-) ss, 2 segment, DS, 10-18 segment, (+) ss, 2 copies ) genome.
-It is virion polymerase ( negative, positive ).
-It's genome size is ( 10, 12, 8, 13-16, 13.5-21, 13.6 ) total in kb.

Explanation

Question 17 of 31

1

The Toga family of viruses is classified as a(n):
-Enveloped RNA virus with Icosahedral symmetry of the capsid.
-It has a (-) ss continuous genome.
-It is virion polymerase negative.

Select one of the following:

True
False

Explanation

Question 18 of 31

1

Which family of viruses has the following characteristics?
-Enveloped RNA virus with Icosahedral symmetry of the capsid.
-It has a (+) ss 2 copies genome architecture.
-It is virion polymerase positve.

Select one of the following:

Retroviruses
Flaviviruses
Togaviruses
Corona viruses
Rhabdoviruses

Explanation

Question 19 of 31

1

Which of the following family of viruses have a (-) single stranded, non-segmented genome architecture? (Select all that apply)

Select one or more of the following:

Reoviruses
Flaviviruses
Togaviruses
Retroviruses
Coronaviruses
Filoviruses
Rhabdoviruses
Paramyxoviruses
Arenaviruses
Bunyaviruses

Explanation

Question 20 of 31

1

Which of the following can the smallest possible genome size?

Select one of the following:

Corona viruses
Rhabdoviruses
Arenaviruses
Flaviviruses
Picornaviruses
Retroviruses

Explanation

Question 21 of 31

1

Adenoviruses is a kind of RNA virus

Select one of the following:

True
False

Explanation

Question 22 of 31

1

Herpes virus, Pox viruses, Togaviruses, and Rhabdoviruses are all enveloped viruses

Select one of the following:

True
False

Explanation

Question 23 of 31

1

Which of the following Naked DNA viruses have a linear genome architecture? (Select all that apply)

Select one or more of the following:

Parvoviruses
Papovaviruses
Adenoviruses
Picornaviruses
Arenaviruses

Explanation

Question 24 of 31

1

Filoviruses do not have virion polymerases.

Select one of the following:

True
False

Explanation

Question 25 of 31

1

The pox virus is a Helical enveloped DNA virus.

Select one of the following:

True
False

Explanation

Question 26 of 31

1

Which of the following does not go with the others?

Select one of the following:

Caliciviruses
Picornaviruses
Flaviviruses
Togaviruses
Retroviruses
Coronaviruses

Explanation

Question 27 of 31

1

The virus life cycle:
1. ❌ - virus ❌ to cellular receptor(s)
2. ❌ - ❌ endocytosis or fusion of viral envelope with cell membrane
3. ❌ - ❌
4. ❌ - ❌
• ❌ transcription
• ❌ translation
• ❌ replication
5. ❌ - depends on type of virus
6. ❌ - ❌ generally release by cell ❌; enveloped viruses release by membrane budding

Drag and drop to complete the text.

Attachment

receptor-mediated

mRNA

protein

nucleic acid

naked viruses

depends on type of virus

depends on entry process

Entry

Uncoating

Release

Assembly

Replication

binding

lysis

Explanation

Question 28 of 31

1

Types of Virus Infection

❌ – infection of a permissive cell: results in virus production, may result in cell death (lytic infection)

❌ – infection of a non- or semi-permissive cell: block to virus production at some step so infection
aborts

❌ – long-lasting virus infection. Can be chronic, latent or slow.

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Acute

Abortive

Persistent

Explanation

Question 29 of 31

1

Persistent infections:
• ❌-low levels of virus produced over a long time, chronic virus production and reinfection of cells

• ❌- virus goes dormant following primary infection, may reactivate infection at subsequent times

• ❌: virus production increases slowly over time

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Chronic

Latent

Slow

Explanation

Question 30 of 31

1

Productive infection- Sequence of events

1. ❌
2. ❌ of viral genes

3. Viral ❌

4. ❌ of virus particles

5. Generally (but not always) ❌ of the host cell

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Virus enters susceptible cells

Replication: Transcription / translation

genome replication occurs

Assembly, maturation, and release

results in death

Explanation

Question 31 of 31

1

Latent Infection: Sequence of events

1.Virus ❌

2. ❌ associated viral genes Viral genes for lytic replication not expressed

3.❌

4. ❌

5. ❌ results in lytic gene expression and production of infectious virus

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enters susceptible cells

Transcription / translation of latency

Maintenance of the viral genome

No progeny virions produced

Reactivation of viral gene expression

	Created by bpasistor about 8 years ago

Going viral

Intro to virology

Question 1 of 31

The outer surface of the capsid mediates with host cells.

Select one of the following:

Explanation

Question 2 of 31

The glycoproteins anchored in the envelope and pointing out mediate contact with the host cells.

Select one of the following:

Explanation

Question 3 of 31

Which type of virus is especially Sensitive to lipid solvents (ex. Chloroform, ether) and also to non-ionic detergents.

Select one of the following:

Explanation

Question 4 of 31

Select from the dropdown lists to complete the text.

Naked Enveloped( Naked, Enveloped ) viruses tend to be more stable to environmental changes than Naked Enveloped( Naked, Enveloped ) viruses.

Explanation

Question 5 of 31

Select from the dropdown list to complete the text.

Naked Enveloped( Naked, Enveloped ) viruses are usually transmitted via aqueous environment: e.g. various body secretions, blood

Explanation

Question 6 of 31

Select from the dropdown list to complete the text.

Naked Enveloped( Naked, Enveloped ) viruses may be transmitted by many routes: e.g. secretions/blood, oral-fecal, skin contact

Explanation

Question 7 of 31

What viral structure is defined as a lipid bilayer derived from host cell membranes during the process of virus maturation.

Select one of the following:

Explanation

Question 8 of 31

Which viral structure is defined as a protein shell that surrounds and protects the viral genome?

Select one of the following:

Explanation

Question 9 of 31

Select from the dropdown list to complete the text.

Icosahedral Helical( Icosahedral, Helical ) structures approximate spheres.

Explanation

Question 10 of 31

Icosahedral structures can have which of the following axis/axes of symmetry? (Select all that apply)

Select one or more of the following:

Explanation

Question 11 of 31

Helical structures can have which of the following axis/axes of symmetry? (Select all that apply)

Select one or more of the following:

Explanation

Question 12 of 31

Select from the dropdown lists to complete the text.

Explanation

Question 13 of 31

Select from the dropdown lists to complete the text.

Explanation

Question 14 of 31

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Explanation

Question 15 of 31

Select from the dropdown lists to complete the text.

Explanation

Question 16 of 31

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Explanation

Question 17 of 31

The Toga family of viruses is classified as a(n): -Enveloped RNA virus with Icosahedral symmetry of the capsid. -It has a (-) ss continuous genome. -It is virion polymerase negative.

Select one of the following:

Explanation

Question 18 of 31

Which family of viruses has the following characteristics? -Enveloped RNA virus with Icosahedral symmetry of the capsid. -It has a (+) ss 2 copies genome architecture. -It is virion polymerase positve.

Select one of the following:

Explanation

Question 19 of 31

Which of the following family of viruses have a (-) single stranded, non-segmented genome architecture? (Select all that apply)

Select one or more of the following:

Explanation

Question 20 of 31

Which of the following can the smallest possible genome size?

Select one of the following:

Explanation

Question 21 of 31

Adenoviruses is a kind of RNA virus

Select one of the following:

( Naked, Enveloped ) viruses tend to be more stable to environmental changes than ( Naked, Enveloped ) viruses.

( Naked, Enveloped ) viruses are usually transmitted via aqueous environment: e.g. various body secretions, blood

( Naked, Enveloped ) viruses may be transmitted by many routes: e.g. secretions/blood, oral-fecal, skin contact

( Icosahedral, Helical ) structures approximate spheres.

The Toga family of viruses is classified as a(n):
-Enveloped RNA virus with Icosahedral symmetry of the capsid.
-It has a (-) ss continuous genome.
-It is virion polymerase negative.

Which family of viruses has the following characteristics?
-Enveloped RNA virus with Icosahedral symmetry of the capsid.
-It has a (+) ss 2 copies genome architecture.
-It is virion polymerase positve.

Persistent infections:
• ❌-low levels of virus produced over a long time, chronic virus production and reinfection of cells

• ❌- virus goes dormant following primary infection, may reactivate infection at subsequent times

• ❌: virus production increases slowly over time

Productive infection- Sequence of events

1. ❌
2. ❌ of viral genes

3. Viral ❌

4. ❌ of virus particles

5. Generally (but not always) ❌ of the host cell

Latent Infection: Sequence of events

1.Virus ❌

2. ❌ associated viral genes Viral genes for lytic replication not expressed

3.❌

4. ❌

5. ❌ results in lytic gene expression and production of infectious virus