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Lecture 10

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Genomic Imprinting

Question 1 of 21

1

Fill the blank space to complete the text.

Genomic imprinting is gene expression that occurs in a manner specific to the parent of origin.

Explanation

Question 2 of 21

1

XY gene expression is an example of imprinting.

Select one of the following:

  • True
  • False

Explanation

Question 3 of 21

1

What percent of genes are imprinted?

Select one of the following:

  • ~5%

  • ~10%

  • <1%

Explanation

Question 4 of 21

1

Imprinting can work for a lifetime, or be stage specific or tissue specific.

Select one of the following:

  • True
  • False

Explanation

Question 5 of 21

1

Fill the blank space to complete the text.

% of imprinted genes exist in clusters

Explanation

Question 6 of 21

1

Which of these is true for imprinted genes in comparison to non-imprinted genes?

Select one of the following:

  • they have fewer introns

  • they have more introns

  • they have smaller introns

  • they have fewer and/or smaller introns

  • they have more but smaller introns

Explanation

Question 7 of 21

1

Which of these is the regulatory element that controls the imprinting of one or more genes? Hint: moving one of these can cause abnormal imprinting.

Select one of the following:

  • Imprinting control regions(ICRs)

  • Differentially methylated regions(DMRs)

  • CpG islands

Explanation

Question 8 of 21

1

Differentially methylated regions can contain imprinting control regions

Select one of the following:

  • True
  • False

Explanation

Question 9 of 21

1

If a DMR has a cis-acting sequence, this means

Select one of the following:

  • it can recruit methyl specific proteins to the SAME strand/chromosome

  • it can recruit methyl specific proteins to the EITHER strand/chromosome

Explanation

Question 10 of 21

1

Fill the blank space to complete the text.

methylated DMRs have low amounts of methylation.

Explanation

Question 11 of 21

1

Fill the blank space to complete the text.

of the DNA can occur so that a distant segment of DNA can interact with another.

Explanation

Question 12 of 21

1

It is completely impossible to make a uniparental embryo

Select one of the following:

  • True
  • False

Explanation

Question 13 of 21

1

Which of these is embryonic lethal?

Select one or more of the following:

  • gynogenetic/parthenogenetic zygote

  • androgenetic zygote

Explanation

Question 14 of 21

1

When, if ever, will demethylation affect imprinted genes?

Select one of the following:

  • fertilization

  • germ cell development

  • morula to blastocyst transition

Explanation

Question 15 of 21

1

If a gene is paternally imprinted, then a male would have one allele methylated and one not(the maternal allele). If this male is going to produce offspring, then both of the alleles must be methylated. When does this occur?

Select one of the following:

  • It will always be like this, as it is male

  • Germ cell development. The methylation status of both alleles is removed, then re-established on both alleles.

  • After fertilization. The sperm contains factors to accomplish paternal imprinting.

Explanation

Question 16 of 21

1

Fill the blank spaces to complete the text.

In one theory of how maternal vs. paternal imprinting controls gene expression, it is theorized that differential chromatin will occur to block the transcription of the imprinted genes. This may be aided by proteins which recognize and attach to 2 different methylated regions at the same time.

In a separate theory, some proteins might recognize and bind methylated or unmethylated imprinted regions and block the transcription of the non imprinted gene(s). This is called the model.

Explanation

Question 17 of 21

1

Imprinted genes are resistant to genome wide DNA demethylation after fertilization.

Select one of the following:

  • True
  • False

Explanation

Question 18 of 21

1

Imprinted genes are resistant to genome wide DNA demethylation during germ cell development.

Select one of the following:

  • True
  • False

Explanation

Question 19 of 21

1

Clones have imprinting.

Drag and drop to complete the text.

    abnormal
    normal

Explanation

Question 20 of 21

1

Fill the blank space to complete the text.

The male and female pronuclei are kept separate until .

Explanation

Question 21 of 21

1

Fill the blank space to complete the text.

The hypothesis states that the paternal genome is more interested in growth, while the maternal genome is interested in resource conservation.

Explanation

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