In these situations, antibiotic therapy should be started on admission to hospital for labour or rupture of membranes, ideally at least 4 hours before delivery, and continued until the neonate is delivered.

Recommended intra-partum antibiotic therapy:

· IV benzylpenicillin 3 g dose followed by 1.8g 4 hourly until delivery

OR If penicillin hypersensitivity (excluding immediate hypersensitivity), IV cephazolin 2 g dose 8 hourly until delivery
OR If immediate penicillin hypersensitivity and GBS isolate known to be susceptible to clindamycin, IV clindamycin 600 mg 8-hourly until delivery
OR If immediate penicillin hypersensitivity and GBS isolate resistant to clindamycin or results of susceptibility testing are not available, IV vancomycin

	Created by Abhijit Das over 10 years ago

Fellowship Obstetrics Note on Antibiotics in obstetrics, created by Abhijit Das on 12/07/2016.